Developmental Pathways to Borderline Personality Disorder: Longitudinal Observational, Clinical, and Neural Predictors From Early Childhood to Young Adulthood

边缘性人格障碍的发展途径：从幼儿期到青年期的纵向观察、临床和神经预测因素

• 批准号: 10734460
• 负责人: Kirsten Gilbert
• 金额: $ 79.12万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10734460
• 关键词: Adolescence; Adolescent; Adult; Age; Aggressive behavior; Amygdaloid structure; Behavioral; Borderline Personality Disorder; Child; Child Rearing; Childhood; Chronically Ill; Clinical; Conflict (Psychology); Data; Data Collection; Data Set; Development; Diagnostic; Disabled Persons; Disease; Early Intervention; Electroencephalography; Environmental Risk Factor; Event; Event-Related Potentials; Exhibits; Face; Functional Magnetic Resonance Imaging; Functional disorder; Funding; General Population; Impairment; Individual; Interview; Lead; Life; Link; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mediating; Mental disorders; Methods; National Institute of Mental Health; Nursery Schools; Onset of illness; Parents; Pathway interactions; Perception; Personality; Personality Disorders; Phenotype; Poverty; Prevention strategy; Process; Psychopathology; Questionnaires; Reporting; Research; Research Domain Criteria; Rest; Risk; Risk Factors; Role; Sampling; Self Concept; Social Processes; Stimulus; Symptoms; System; Testing; Underemployment; Vent; Youth; clinically significant; cost effective; design; disability; early childhood; early onset; emerging adult; emotion dysregulation; indexing; intervention cost; magnetic resonance imaging/electroencephalography; middle childhood; mortality; neural; neural circuit; neural correlate; novel; peer; prevent; prospective; response; social; suicide rate; young adult

PROJECT SUMMARY Borderline Personality Disorder (BPD) is a prominent contributor to disability, burden, and increased mortality. Although impairments in self (RDoC Systems for Social Processes: Perception and understanding of self) and interpersonal (RDoC Systems for Social Processes: Affiliation) functioning originate in early childhood, little is known about the developmental psychopathology of these core features in BPD, as opposed to a related psychiatric disorder that often precedes and co-develops with BPD: Major Depressive Disorder (MDD). The current proposal will establish developmental trajectories of interpersonal and self dysfunction from early childhood into young adulthood, examining interactions with environmental factors and associations with aberrant neural circuitry, to predict onset of BPD in early adulthood. In this renewal, we leverage 17 years of previously collected longitudinal data (R01 MH090786) from 348 young children enriched for emotional dysregulation. Now young adults (19-25 years), 36% exhibit BPD above diagnostic threshold. This sample offers an unparalleled opportunity to understand specific developmental precursors for BPD onset. Rich phenotyping, including over a decade of clinical interviews, narratives, questionnaires, observations, and repeated MRI and EEG assessments make this the ideal and highly cost-effective dataset to investigate impairments in self and interpersonal functioning that lead to BPD versus MDD. New data collection in young adulthood includes multi-method assessments of interpersonal and self functioning alongside psychiatric diagnostic interviews. Our motivating hypothesis is that in the context of emotion dysregulation, peer acceptance and aggression (interpersonal dysfunction) from preschool through middle childhood, interacts with self-functioning (unstable, incoherent self-worth and self- concept) in adolescence to uniquely predict BPD onset in adulthood versus MDD. We will examine: (1) how specific aspects of these constructs prospectively relate to adult BPD, as opposed to continuation of MDD; (2) during which developmental periods these constructs provide the most predictive utility, including the moderating effect of specific environmental factors; and (3) assess the predictive and mechanistic role of neural correlates of these constructs in forecasting BPD versus MDD. Findings will inform the optimal timing and content-focus (i.e., specific neural/behavioral self and interpersonal targets) of novel early-intervention for preventing BPD during the earliest developmental periods. This longitudinal research will be able to identify risk factors for the persistence or worsening of interpersonal and self dysfunction and BPD onset, offering the best starting point toward developing a prevention strategy for BPD.

项目总结

项目成果

Resting state functional connectivity of the ventral attention network in children with a history of depression or anxiety.

• DOI: 10.1016/j.jaac.2013.10.001
• 发表时间: 2013-12
• 期刊: JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
• 影响因子: 13.3
• 作者: Sylvester, Chad M.;Barch, Deanna M.;Corbetta, Maurizio;Power, Jonathan D.;Schlaggar, Bradley L.;Luby, Joan L.
• 通讯作者: Luby, Joan L.

Depression and Anxiety in Preschoolers: A Review of the Past 7 Years.

学龄前儿童的抑郁和焦虑：过去 7 年的回顾。

• DOI: 10.1016/j.chc.2017.02.006
• 发表时间: 2017
• 期刊: Child and adolescent psychiatric clinics of North America
• 影响因子: 2.4
• 作者: Whalen,DianaJ;Sylvester,ChadM;Luby,JoanL
• 通讯作者: Luby,JoanL

Face processing in adolescents with positive and negative threat bias.

• DOI: 10.1017/s003329171600310x
• 发表时间: 2017-04
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Sylvester CM;Petersen SE;Luby JL;Barch DM
• 通讯作者: Barch DM

Correlating Psychotropic Use to Major Depressive Disorder and ADHD Research Diagnoses: Trends in a Prospective Pediatric Cohort From Ages 3 to 21.

将精神药物的使用与重度抑郁症和多动症研究诊断相关联：3 至 21 岁预期儿科队列的趋势。

• DOI: 10.4088/jcp.21m14331
• 发表时间: 2022
• 期刊: The Journal of clinical psychiatry
• 作者: Liang,MirandaU;Charatcharungkiat,Natchanan;Tillman,Rebecca;Patel,HetalM;Vogel,AleciaC;Luby,JoanL
• 通讯作者: Luby,JoanL

Shyness and Trajectories of Functional Network Connectivity Over Early Adolescence.

• DOI: 10.1111/cdev.13005
• 发表时间: 2018-05
• 期刊: Child development
• 影响因子: 4.6
• 作者: Sylvester CM;Whalen DJ;Belden AC;Sanchez SL;Luby JL;Barch DM
• 通讯作者: Barch DM