Neuropathological changes underlying clinical heterogeneity in Alzheimer disease

项目摘要 这是加州大学神经病理学家Lea T.Grinberg博士的K24奖续签申请 加州，旧金山(加州大学旧金山分校)。格林伯格博士是驻校副教授，并共同领导 加州大学旧金山分校/记忆和老龄化中心的神经病理核心。她是这位病人的资深研究人员- 以痴呆为导向的临床研究。她研究的一个显著特点是她直接参与了创作， 管理和分析属于高危人群的具有良好特征的尸检脑集合 已经患有痴呆症了。格林伯格博士建议利用K24专门的时间来指导USCF和国际 以病人为中心的痴呆症研究中的研究人员。她的学员将获得实践研究经验， 与年龄有关的人类神经病理学、数据分析培训、手稿准备和补助金方面的专业知识 写作，以及职业生涯，指导。学员培训将利用 加州大学旧金山分校/记忆和老龄化中心尸检计划，这是正在进行的纵向队列研究的一部分 以及她与国内痴呆症领域多学科研究人员的合作以及 全世界。格林伯格博士打算进行K24支持的阿尔茨海默氏症研究，这将有助于 作为学员的培训工具，并扩大她的研究。这些研究使用临床、遗传学和 神经病理数据，将使用正在进行的加州大学旧金山分校/记忆和老龄化中心的NIH- 资助阿尔茨海默病(AD)患者的队列研究。她将研究选择性背后的因素 阿尔茨海默病的神经元易损性。总之，这款K24将通过以下方式加强金伯格博士的积极研究计划 加州大学旧金山分校的广泛基础设施支持她在神经退行性疾病领域保持领先地位的目标， 特别是在神经病理学领域，并制定一项卓越的医学生培养计划， 与年龄相关的神经病理学相关的POR的实习生和初级教员，也是为了弥合差距 由于神经科医生的神经病理学培训中断和神经退行性疾病培训 神经病理学家。

Project Summary This is an application for K24 award renewal for Dr. Lea T. Grinberg, a neuropathologist at the University of California, San Francisco (UCSF). Dr. Grinberg is an Associate Professor in Residence and co-lead the UCSF/Memory and Aging Center's Neuropathology Core. She is an established researcher in the patient- oriented clinical research of dementia. A distinctive hallmark of her research is her direct involvement in creating, managing, and analyzing well-characterized postmortem collections of brains belonging to people at-risk or already with dementia. Dr. Grinberg proposes to use K24 dedicated time to mentor USCF as well as international investigators in patient-oriented dementia research. Her mentees will gain hands-on research experience, expertise in age-related human neuropathology, training in data analysis, manuscript preparation, and grant writing, as well as career, mentoring. Mentee training will leverage the infrastructure and resources of the UCSF/Memory and Aging Center Autopsy program, which is part of ongoing longitudinal cohort studies, research portfolio, and her collaborations with multidisciplinary researchers in the areas of dementia domestically and worldwide. Dr. Grinberg intends to conduct K24-supported Alzheimer's disease research studies that will serve as training vehicles for mentees and expand her research. These studies, using clinical, genetic, and neuropathological data, will be conducted using data from ongoing UCSF/Memory and Aging Center's NIH- funded cohort studies of persons with Alzheimer's disease (AD). She will examine the factors underlying selective neuronal vulnerability in AD. In summary, this K24 will enhance Dr. Ginberg's active research program with extensive infrastructure at UCSF to support her goal to remain a leader in neurodegenerative diseases, especially in the field of neuropathology, and to develop a program of excellence for training medical students, trainees, and junior faculty in POR related to age-related neuropathology that is also intended to close the gaps caused by interruption of neuropathology training for neurologists and neurodegenerative disease training for neuropathologists.