Neuropathological changes underlying clinical heterogeneity in Alzheimer disease

阿尔茨海默病临床异质性背后的神经病理学变化

• 批准号: 10448265
• 负责人: Lea Tenenholz Grinberg
• 金额: $ 18.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448265
• 关键词: Age; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease therapy; Amnestic Disorder; Amyloid; Amyloid beta-Protein; Area; Atrophic; Automobile Driving; Autopsy; Biological; Brain; Brain region; California; Cell Nucleus; Cells; Cessation of life; Clinical; Clinical Research; Cognitive; Cohort Studies; Collaborations; Collection; Data; Data Analyses; Dementia; Disease; Epidemiology; Faculty; Functional disorder; Funding; Goals; Grant; Heterogeneity; Hippocampal Formation; Human; Immunofluorescence Immunologic; Impaired cognition; In Situ Hybridization; Individual; Infrastructure; International; Interruption; Intrinsic factor; Lead; Lesion; Libraries; Longitudinal cohort study; Machine Learning; Manuscripts; Medical Genetics; Medical Students; Memory; Mentors; Metabolic; Methods; Mid-Career Clinical Scientist Award (K24); Molecular; Neurobiology; Neurodegenerative Disorders; Neurofibrillary Tangles; Neuroglia; Neurologist; Neurons; Pathologic; Pathology; Pathway interactions; Pattern; Persons; Phenotype; Preparation; Prevention; Primary Progressive Aphasia; Protocols documentation; Regional Disease; Research; Research Personnel; Research Training; Risk; Role; San Francisco; Senile Plaques; Small Nuclear RNA; Symptoms; Syndrome; Testing; Time; Tissue Sample; Tissues; Training; Training Programs; Transcript; United States National Institutes of Health; Universities; University resources; Variant; Work; Writing; age related; association cortex; asymptomatic Alzheimer' s disease; base; behavioral variant frontotemporal dementia; brain tissue; career; cerebral atrophy; clinical heterogeneity; comorbidity; corticobasal syndrome; differential expression; effective therapy; experience; extracellular; hands on research; innovation; interdisciplinary approach; mid-career faculty; multidisciplinary; neocortical; neuron loss; neuronal patterning; neuropathology; neurotoxicity; novel; novel marker; patient oriented; prevent; programs; recruit; regional difference; research study; residence; tau Proteins; tau aggregation; transcriptome sequencing

Project Summary This is an application for K24 award renewal for Dr. Lea T. Grinberg, a neuropathologist at the University of California, San Francisco (UCSF). Dr. Grinberg is an Associate Professor in Residence and co-lead the UCSF/Memory and Aging Center's Neuropathology Core. She is an established researcher in the patient- oriented clinical research of dementia. A distinctive hallmark of her research is her direct involvement in creating, managing, and analyzing well-characterized postmortem collections of brains belonging to people at-risk or already with dementia. Dr. Grinberg proposes to use K24 dedicated time to mentor USCF as well as international investigators in patient-oriented dementia research. Her mentees will gain hands-on research experience, expertise in age-related human neuropathology, training in data analysis, manuscript preparation, and grant writing, as well as career, mentoring. Mentee training will leverage the infrastructure and resources of the UCSF/Memory and Aging Center Autopsy program, which is part of ongoing longitudinal cohort studies, research portfolio, and her collaborations with multidisciplinary researchers in the areas of dementia domestically and worldwide. Dr. Grinberg intends to conduct K24-supported Alzheimer's disease research studies that will serve as training vehicles for mentees and expand her research. These studies, using clinical, genetic, and neuropathological data, will be conducted using data from ongoing UCSF/Memory and Aging Center's NIH- funded cohort studies of persons with Alzheimer's disease (AD). She will examine the factors underlying selective neuronal vulnerability in AD. In summary, this K24 will enhance Dr. Ginberg's active research program with extensive infrastructure at UCSF to support her goal to remain a leader in neurodegenerative diseases, especially in the field of neuropathology, and to develop a program of excellence for training medical students, trainees, and junior faculty in POR related to age-related neuropathology that is also intended to close the gaps caused by interruption of neuropathology training for neurologists and neurodegenerative disease training for neuropathologists.

项目概要 这是纽约大学神经病理学家 Lea T. Grinberg 博士的 K24 奖项续签申请。 加利福尼亚州、旧金山 (UCSF)。 Grinberg 博士是常驻副教授，并共同领导 加州大学旧金山分校/记忆与衰老中心的神经病理学核心。她是一位在患者领域颇有建树的研究员—— 面向痴呆症的临床研究。她的研究的一个显着特点是她直接参与创造， 管理和分析属于高危人群的死后大脑收集品 已经患有痴呆症。 Grinberg 博士建议利用 K24 的专门时间来指导 USCF 以及国际组织 以患者为导向的痴呆症研究的研究者。她的学员将获得实践研究经验， 与年龄相关的人类神经病理学方面的专业知识、数据分析培训、手稿准备和资助 写作，以及职业、指导。学员培训将利用基础设施和资源 加州大学旧金山分校/记忆与衰老中心尸检计划，这是正在进行的纵向队列研究、研究的一部分 作品集，以及她与国内外痴呆症领域多学科研究人员的合作 全世界。 Grinberg 博士打算开展 K24 支持的阿尔茨海默病研究，该研究将服务于 作为学员的培训工具并扩大她的研究。这些研究利用临床、遗传和 神经病理学数据，将使用来自 UCSF/记忆和衰老中心 NIH 正在进行的数据进行 资助阿尔茨海默病（AD）患者的队列研究。她将研究选择性的潜在因素 AD 中的神经元脆弱性。总之，这款 K24 将通过以下方式增强 Ginberg 博士的积极研究计划： 加州大学旧金山分校广泛的基础设施支持她保持神经退行性疾病领域领导者的目标， 特别是在神经病理学领域，并制定培训医学生的卓越计划， 与年龄相关的神经病理学相关的 POR 学员和初级教师也旨在缩小差距 由于神经科医生的神经病理学培训和神经退行性疾病培训的中断而引起 神经病理学家。