1/2-Bangladesh Center for Global Environmental and Occupational Health- Bangladesh

1/2-孟加拉国全球环境和职业健康中心-孟加拉国

• 批准号: 10447840
• 负责人: Habibul Ahsan
• 金额: $ 28.9万
• 依托单位: INTERNATIONAL CTR/DIARRHOEAL DIS RES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10447840
• 关键词: Adoption; Adult; Agriculture; Air Pollutants; Air Pollution; Anti-Inflammatory Agents; Antibodies; Antibody Response; Antigens; Area; Arrhythmia; Atherosclerosis; Award; B-Lymphocytes; Bangladesh; Behavioral; Biomass; Blood Pressure; COVID-19 vaccination; Car Phone; Carbon Black; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Cattle; Chicago; Child; Chronic; Clinical Markers; Communication; Communities; Companions; Cytoplasmic Granules; Data; Developed Countries; Disease Outcome; Educational Intervention; Effector Cell; Electrocardiogram; Ensure; Environmental Health; Exposure to; Fasting; Functional disorder; GTP-Binding Protein alpha Subunits, Gs; Gases; Glycosylated hemoglobin A; Government; Grant; Granzyme; Health; Health Benefit; Health Hazards; Hour; Household; Household Air Pollution; Immune; Immune System Diseases; Immune response; Immunoglobulin G; Immunoglobulin M; Impairment; Industrial Waste; Industrialization; Industry; Inflammation; Inflammatory; Inflammatory Response; Inflammatory Response Pathway; Interferon Type II; Intervention; Intervention Trial; Link; Lipids; Long-Term Effects; Lung; Lymphocyte Subset; Measures; Memory; Metabolic Marker; Metabolic dysfunction; Mobile Health Application; Monitor; Natural Immunity; Natural Killer Cells; Occupational Health; Participant; Particulate Matter; Peripheral Blood Mononuclear Cell; Persons; Petroleum; Pilot Projects; Policies; Population; Proteins; Public Health; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonary Pathology; Questionnaires; Randomized; Randomized Controlled Trials; Regulation; Research; Resources; Risk; Social Impacts; South Asian; Surveys; T-Lymphocyte; T-Lymphocyte and Natural Killer Cell; TNF gene; Technology; Thoracic Radiography; Training; Universities; Urbanization; Vaccines; Vital capacity; Woman; Women' s Health; Wood material; Work; adaptive immunity; base; biomass fuel; blood pressure elevation; carotid intima-media thickness; chest computed tomography; cohort; cooking; cost effective; cost efficient; cytokine; cytotoxic; deep learning; design; endoplasmic reticulum stress; fine particles; follow-up; global environment; immune function; innovation; learning strategy; low and middle-income countries; mHealth; monocyte; mortality; non-smoking; novel; perforin; post intervention; pre-clinical; programs; pulmonary function; pulmonary function decline; remediation; trend; ultrasound; young woman

PROJECT SUMMARY Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking. While health risks associated with air-pollution have been reasonably well-studied in developed countries, there is little evidence on health benefits achievable by HAP reduction through clean fuel use, especially in low- and middle-income countries (LMICs). Bangladesh GEOHealth hub has established a cohort of biomass fuel users (n=660). We observed that an increased HAP exposure was associated with lung function decline, increased blood pressure and disruption of innate and adaptive immune function. We observed a drastic reduction in HAP exposure by exclusive liquified petroleum gas (LPG) stove use for 24 months, resulting changes in immune and inflammatory responses in women and in children. However, changes in chronic cardio-pulmonary markers were challenging mostly due to short duration of follow up. In quest for an innovative cost effective, adaptable, and scalable intervention as the possible next step, we planned to conduct a large household level randomized controlled trial by educational intervention using mobile phone (mHealth) based technology. In addition, we will continue following the cohort and will conduct rigorous and repeated personalized (24-48 hours) and area (over 5 days) assessments of PM2.5 and black carbon (BC) exposure to examine the long-term effects of HAP reduction on subclinical measures of cardio-pulmonary and immune dysfunction including effect of HAP exposure on antibody response to vaccine. We will also use deep learning methods to identify lung pathology in relation to HAP. Finally, we propose two exploratory studies on health effects of industrial waste and garment industry work. The aims of this study are scientifically important and directly policy-relevant and consistent with the GEOHealth program agenda. 1

项目摘要 全球近30亿人口，包括孟加拉国的89％的人，暴露于有害 由生物质燃烧（木材，农业残留物，牛粪 等等）烹饪燃料。虽然与空袭相关的健康风险已得到充分研究 发达国家，几乎没有证据表明通过清洁燃料减少HAP可实现的健康益处 使用，特别是在低收入和中等收入国家（LMIC）。孟加拉国地卫生枢纽已建立 生物质燃料用户的队列（n = 660）。我们观察到HAP暴露与肺有关 功能下降，血压升高以及先天和适应性免疫功能的破坏。我们 观察到通过独家液化石油气（LPG）炉灶的使用急剧降低了24 几个月，妇女和儿童的免疫和炎症反应发生了变化。然而， 慢性心肺标记的变化主要是由于随访时间较短。在 寻求创新的成本效益，适应性和可扩展干预作为下一步的可能性，我们 计划通过使用移动 基于电话（MHealth）的技术。此外，我们将继续跟随队列，并将进行严格 以及重复的个性化（24-48小时）和面积（超过5天）PM2.5和黑碳（BC）的评估 暴露于检查减少HAP对心肺亚临床措施的长期影响 免疫功能障碍，包括HAP暴露对疫苗抗体反应的影响。我们还将使用深 学习与HAP有关的肺病理学的学习方法。最后，我们提出了两项​​探索性研究 工业废物和服装行业工作的健康影响。这项研究的目的在科学上很重要 并直接与政策与地理健康计划议程一致。 1