Illinois Precision Medicine Consortium

伊利诺伊州精准医学联盟

• 批准号: 10907875
• 负责人: Habibul Ahsan
• 金额: $ 160万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10907875
• 关键词: Address; All of Us Research Program; Area; Arthritis; Award; Behavioral; Cessation of life; Chicago; China; Clinic; Clinical Informatics; Collaborations; Communities; Complex; Consent; Coronary heart disease; Data; Data Collection; Disease; Economics; Electronic Health Record; Enrollment; Environmental Exposure; Epidemiology; Ethnic Origin; Genetic; Genetic Research; Genomics; Geography; Goals; Greenland; Health; Health Insurance; Health Personnel; Health Service Area; Health Technology; Health system; Human; Hybrids; Illinois; Individual; Institution; International; Logistics; Malignant Neoplasms; Measurement; Medical center; Midwestern United States; Minority Health Research; Modeling; Observational epidemiology; Outcome; Participant; Patients; Persons; Population; Population Heterogeneity; Precision Medicine Initiative; Prevention; Process; Questionnaires; Regional Medical Programs; Research; Research Personnel; Resources; Stroke; Technology; Trust; Universities; Veterans; age group; biobank; clinical phenotype; cohort; community based participatory research; demented; disability; empowerment; epidemiology study; ethnic diversity; experience; genetic linkage; human disease; improved; innovation; insurance claims; interoperability; mHealth; metropolitan; mobile computing; multidisciplinary; novel strategies; participant enrollment; patient engagement; patient population; precision medicine; recruit; response; sex; social; socioeconomics; success; transmission process; volunteer

1.1 Overview Precision medicine seeks to capitalize on growing capabilities in the areas of genomics, clinical phenotyping, clinical informatics, electronic health record (EHR) availability and interoperability, and mobile health technologies to improve understanding of human health and disease. Improved understanding of the complex interplay of genetic and environmental exposures, beyond those previously available in long-term observational epidemiological research, holds the promise of better prediction, prevention, and treatment of a host of human diseases including coronary heart disease, stroke, numerous cancers, dementing illnesses, arthritis, and other major causes of disability and early death. Internationally, efforts to address the opportunities of precision medicine have led to the assembly of large cohorts in the UK (UK Biobank), the China Kadoorie Biobank, and in a selected sub-population in the US (the Million Veteran Project - MVP). In January 2015, President Obama announced a plan for the Precision Medicine Initiative (PMI) to address this significant scientific opportunity. This is a unified multi-PI application (Drs. Greenland, Ahsan, Daviglus and Winn) from the Illinois Precision Medicine Consortium (IPMC) representing 3 major Chicago-area academic institutions (Northwestern University, University of Chicago, and the University of Illinois at Chicago) and their healthcare provider organization (HPO) partners, in response to OT-PM-18-001, Limited Competition: All of Us Research Program Regional Medical Center Healthcare Provider Organizations (OT2). Our goal is to continue our partnership with the All of Us Research Program (AoURP), to recruit and enroll a diverse patient population, contributing to the overall total of one million or more individuals across all age groups from both sexes, including both healthy people and those with pre-existing diseases (without regard to specific disease type), and to follow them through innovative mobile health technologies, electronic health records (EHR), and health insurance claims data to enable linkage of genetic and environmental exposures with a broad array of health outcomes. This consortium brings together the extensive preexisting research resources across the 3 academic institutions, as well as the widespread, yet geographically distinct, service areas of their HPO partners representing numerous ethnically and socioeconomically diverse Chicago and Illinois communities. These longstanding relationships of trust are well established. The IPMC has so far reached and exceeded milestones for organization, participation in national planning, and successful recruitment and logistics. For the OT award period, we will continue to utilize a highly participatory and empowered model of diverse participant engagement and enrollment. The data collected from the geographically and ethnically diverse IPMC population, representing the largest and most diverse urban metropolitan area in the Midwestern United States, will add significant value to the overall AoURP goal of enrolling, retaining, and interacting with 1 million US residents. We have assembled a multidisciplinary team of academic researchers, community partners, and health system leaders in the past year. This application builds upon the collective experience and demonstrated success of the 3 partnering institutions in assembly and retention of large epidemiological cohorts, questionnaire data collection, community-based participatory research, minority health research, EHR linkage for genetic research, and their established and ongoing cross- institution collaborations. For this 5-year project period, IPMC plans to enroll 20,000 full participants each year during Years 1 to 3, 18,000 full participants in Year 4, and 15,000 full participants in Year 5. As such, we will consent, conduct physical measurements, collect biospecimens, and transmit curated data to the AoURP Data and Research Center (DRC; Vanderbilt University) and processed biosamples to the AoURP Biobank (Mayo Clinic), on at least 93,000 people from diverse ethnic, social, and economic backgrounds. Further, we aim to broaden our enrollment from patients in IPMC HPOs (and their affiliates), to include direct volunteers (DV), once this capability becomes technically feasible. To reach enrollment milestones, we will engage HPO staff, patients, and the general community to generate support for and participation in the HPO cohort. We will also engage DV corporate partners, such as Walgreens which is headquartered in Deerfield, IL, to collaborate on implementation of HPO/DV Hybrid strategies. We will continue detailed tracking of success rates, including percentage participation and diversity of participation, and discern the most effective recruitment strategies for each participating HPO. We will also continuously adapt, refine and introduce new approaches to maintain recruitment targets. When available, we will employ mobile technologies as developed by the Technology Coordinating Center, and continuously engage participants to remain connected to the AoURP. In aggregate, the academic institutions, HPOs, and community partners represented in this application provide unparalleled expertise and opportunity to reach a geographically and demographically broad and diverse population that is representative of the US as a whole. The population of the greater Chicago and Illinois area brings a unique opportunity to study common and unique environmental, behavioral and genetic underpinnings of health and disease that can inform the precision medicine of tomorrow.

1.1概述精密医疗寻求利用基因组学、临床表型鉴定、临床信息学、电子健康记录(EHR)可用性和互操作性以及移动健康技术等领域日益增长的能力，以加强对人类健康和疾病的了解。对遗传和环境暴露之间复杂相互作用的了解的加深，超越了以前在长期观察性流行病学研究中可用的那些，有望更好地预测、预防和治疗一系列人类疾病，包括冠心病、中风、多种癌症、痴呆性疾病、关节炎和其他导致残疾和过早死亡的主要原因。在国际上，应对精准医学机遇的努力导致了英国(英国生物库)、中国嘉道理生物库和美国选定的子群体(百万老兵计划-MVP)的大型群体聚集。2015年1月，奥巴马总统宣布了一项精准医学倡议(PMI)计划，以应对这一重大的科学机遇。 这是代表芝加哥地区三大学术机构(西北大学、芝加哥大学和伊利诺伊大学芝加哥分校)和他们的医疗保健提供商组织(HPO)合作伙伴的伊利诺伊州精密医学联盟(IPMC)为响应OT-PM-18-001，有限竞争：我们所有人的研究计划区域医疗保健提供商组织(OT2)的统一多PI应用程序(Dr.Greenland，Ahsan，Daviglus和Winn)。我们的目标是继续与我们所有人研究计划(AoURP)合作，招募和招募多样化的患者群体，为包括健康人和既往疾病患者(不考虑特定疾病类型)的所有年龄段的总人数贡献100万或更多的人，并通过创新的移动医疗技术、电子健康记录(EHR)和医疗保险索赔数据跟踪他们，使遗传和环境暴露与广泛的健康结果联系起来。该联盟汇集了3个学术机构先前存在的大量研究资源，以及他们的HPO合作伙伴代表众多种族和社会经济多样性的芝加哥和伊利诺伊州社区的广泛但地理上不同的服务领域。这些长期的信任关系是建立得很好的。 到目前为止，IPMC在组织、参与国家规划以及成功招聘和后勤方面已经达到并超过了里程碑。在OT奖励期间，我们将继续使用高度参与性和授权的模式，让不同的参与者参与和注册。从地理和种族多样化的IPMC人口中收集的数据代表了美国中西部最大和最多样化的城市大都市区，这将为AoURP登记、保留100万美国居民并与其互动的总体目标增加重大价值。在过去的一年里，我们组建了一个由学术研究人员、社区伙伴和卫生系统领导人组成的多学科团队。这项应用建立在3个伙伴机构在收集和保留大型流行病学队列、问卷数据收集、基于社区的参与性研究、少数群体健康研究、遗传研究的电子健康记录联系以及它们已建立和正在进行的跨机构合作方面的集体经验和所展示的成功。 在这个为期5年的项目期间，IPMC计划在第1至第3年每年招收20,000名正式参与者，第4年招收18,000名正式参与者，第5年招收15,000名正式参与者。因此，我们将对来自不同种族、社会和经济背景的至少93,000人进行同意、进行身体测量、收集生物标本并将经过整理的数据传输到AoURP数据和研究中心(DRC；Vanderbilt University)，并将生物样本处理到AoURP生物库(Mayo Clinic)。此外，一旦这种能力在技术上可行，我们的目标是扩大我们从IPMC HPOS(及其附属机构)患者的登记范围，包括直接志愿者(DV)。为了达到登记的里程碑，我们将动员HPO工作人员、患者和一般社区为HPO队列提供支持和参与。我们还将与DV公司合作伙伴，如总部位于伊利诺伊州迪尔菲尔德的Walgreens，就HPO/DV混合战略的实施进行合作。我们将继续详细跟踪成功率，包括参与百分比和参与的多样性，并为每一名参与的HPO确定最有效的招聘策略。我们还将不断调整、完善和引入新的方法，以保持招聘目标。当可用时，我们将采用技术协调中心开发的移动技术，并不断吸引参与者保持与AoURP的连接。总体而言，本申请中代表的学术机构、HPO和社区合作伙伴提供了无与伦比的专业知识和机会，以接触到代表整个美国的地理和人口结构广泛和多样化的人口。大芝加哥和伊利诺伊地区的人口带来了一个独特的机会，可以研究共同和独特的环境、行为和遗传基础 可以告知明天的精准医学的疾病。

项目成果

The Impact of Social Isolation and Environmental Deprivation on Blood Pressure and Depression-Like Behavior in Young Male and Female Mice.

社会隔离和环境剥夺对年轻男性和女性小鼠血压和抑郁症行为的影响。

• DOI: 10.1177/24705470231207010
• 发表时间: 2023-01
• 期刊: Chronic stress (Thousand Oaks, Calif.)
• 作者: Challa, Siva Reddy;Fornal, Casimir A;Wang, Billy C;Boyineni, Jerusha;DeVera, Roberto E;Unnam, Pavani;Song, Yajing;Soares, Marcelo Bento;Malchenko, Sergey;Gyarmati, Peter;Veeravalli, Krishna Kumar
• 通讯作者: Veeravalli, Krishna Kumar