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Frugal Science Academy: Training K-12 innovators and democratizing synthetic biology tools

节俭科学院：培训 K-12 创新者并使合成生物学工具民主化

基本信息

批准号：
10450255
负责人：
SAAD BHAMLA
金额：
$ 27万
依托单位：
GEORGIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-16 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10450255
关键词：
3D Print Academy Address Adoption African American student Award Biomedical Engineering Biomedical Research Biotechnology Budgets Capital Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Conscious Creativeness Development Drops Education Educational Curriculum Educational workshop Engineering Environment Equipment Exposure to Festival Funding Future Teacher Goals High School Faculty High School Student Human Human Genome Project Hybrids Infrastructure Institution Internships Laboratories Learning Methods Microscope Mission Modern 1601-history Molecular Molecular Biology Names Paper Pathway interactions Prize Publications RNA vaccine Reproducibility Research Research Institute Research Personnel Research Project Grants Resource-limited setting Resources Rural Rural Developments STEM field STEM research Schools Science Students Talents Teacher Professional Development Technology Training Training and Education Translations Underrepresented Minority Underrepresented Populations Underrepresented Students United States National Institutes of Health Universities Work biological research career cost course development design digital education resources equipment training experience experimental study fundamental research genome editing genome sequencing hands on research hands-on learning health application high school innovation invention laboratory equipment lens maker-faire meetings member next generation novel nucleotide metabolism online course portability posters response rural area science education skill acquisition socioeconomics student training success symposium synthetic biology teacher tool trend undergraduate student underrepresented minority student virtual

项目摘要

Project Summary/Abstract Given modern history’s advancements in molecular biology, from the exponential decrease in the costs of genome sequencing, nucleotide synthesis, and genome editing (CRISPR), synthetic biology is poised to be the next major revolution in technological advancements. The White House has recognized this trend in its 2019 Bioeconomy Summit, emphasizing the need for developing a robust bioeconomy and training the next generation workforce to carry it forward. However, research and education in synthetic biology has remained predominant in well-funded graduate research institutes with easy access to commercial equipment and training. Those in high schools and undergraduate pathways have not seen the same accessibility despite them being the prime target for advancement into research careers and extensive research indicates the value in diversification of the workforce. A key bottleneck for enabling hands-on training in synthetic biology is lack of affordable hardware, especially in budget-conscious high school laboratories. Recent initiatives in frugal science have attempted to address some of these bottlenecks with notable frugal inventions including the 20-cent paper centrifuge, 23-cent electroporator, and 1- dollar microscope, to name a few. The proposed work will develop a Frugal Science Academy, a first-of-its-kind, to i) train underrepresented groups (URM) in K-12 STEM to conduct their own research in synthetic/molecular biology by developing their own frugal tools and gain research experiences often exclusive to well-equipped universities, and ii) to develop professional development courses and bootcamps to train rural Georgia high-school teachers with frugal hardware to conduct their own molecular biology experiments and introduce synthetic biology components to their existing curricula. Overall, the success of the Frugal Science Academy will help introduce younger innovators and inventors to the rapidly expanding field of synthetic biology, empower them to conduct their own biomedical research and biological research by breaking down cost barriers using frugal equipment, and collaborate with teachers to begin a new widespread initiative of synthetic biology curricula in high school classrooms.

项目概要/摘要鉴于现代历史上分子生物学的进步，从基因组测序、核苷酸合成和基因组编辑 (CRISPR)、合成的成本生物学有望成为技术进步的下一次重大革命。白宫在2019年生物经济峰会上认识到了这一趋势，强调需要发展强大的生物经济并培训下一代劳动力以推动其发展。然而，合成生物学的研究和教育在资金充足的研究生中仍然占主导地位研究机构可以轻松获得商业设备和培训。那些在高中的人尽管本科途径是主要途径，但它们并没有看到同样的可访问性进入研究职业的目标和广泛的研究表明了劳动力多元化。实现合成实践培训的关键瓶颈生物学缺乏负担得起的硬件，特别是在预算有限的高中实验室。最近节俭科学领域的举措试图通过以下方法解决其中一些瓶颈：著名的节俭发明包括 20 美分纸离心机、23 美分电穿孔器和 1- 仅举几例，美元显微镜。拟议的工作将建立一个节俭科学院，一个首创，i) 在 K-12 STEM 中培训代表性不足的群体 (URM) 开展自己的活动通过开发自己的节俭工具进行合成/分子生物学研究并获得研究成果经验通常是装备精良的大学所独有的，并且 ii) 培养专业人才发展课程和训练营，以节俭的方式培训佐治亚州农村高中教师进行自己的分子生物学实验并引入合成生物学的硬件现有课程的组成部分。总体而言，节俭科学院的成功将有助于引进年轻的创新者和发明家进入快速扩展的合成生物学领域，使他们能够开展自己的研究通过使用节俭打破成本障碍来进行生物医学研究和生物研究设备，并与教师合作开始合成生物学的新的广泛倡议高中课堂的课程。