Biophysical mechanism and synthetic engineering of optically-controlled Ca2+- powered supramolecular engines

光控Ca2驱动超分子发动机的生物物理机制与合成工程

• 批准号: 10797665
• 负责人: SAAD BHAMLA
• 金额: $ 24.99万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10797665
• 关键词: Administrative Supplement; Biophysical Process; Biotechnology; Cells; Engineering; Equilibrium; Equipment; Health; Investigation; Knowledge; Learning; Life; Medicine; Memory; Neurons; Optics; Organism; Parents; RNA; Research; Role; System; cost; disability; equipment acquisition; experimental study; innovative technologies; instrument; transcriptome sequencing

Abstract The proposed Administrative Supplement to R35GM142588 (MIRA) aims to purchase a FluidFM OMNIUM CORE instrument to explore the role of RNA in single-cell learning in Spirostomum ambiguum. This cutting-edge instrument will allow the lab to conduct live RNA sequencing experiments on living cells, enabling the investigation of single-cell learning without neurons. The purchase of the instrument is justified as it furthers the aims of the MIRA proposal and has the potential to open up new avenues of research on memory storage and transfer in aneural organisms, with potential applications in medicine and biotechnology. The proposal has the potential to introduce new paradigms for "memory molecules" that could be stored, modified, or transferred between living and synthetic systems. The purchase of the instrument is justified as it furthers the aims of the MIRA proposal, the need is justified, and the equipment cost is within $250k. The unobligated balance on the parent R35 MIRA is approximately $90,000, which is not enough to cover the purchase of the instrument.

抽象的 R35GM142588（MIRA）拟议的行政补充旨在购买FluidFM Omnium 探索RNA在Spirostomum Ambiguum中的单细胞学习中的作用的核心工具。这个尖端 仪器将允许实验室在活细胞上进行实时RNA测序实验，从而使 研究没有神经元的单细胞学习。购买乐器的购买是合理的 MIRA提案的目的，并有可能在记忆存储和 在动脉外生物体中转移，并在医学和生物技术中进行了潜在的应用。该提议有 可能引入可以存储，修改或转移的“记忆分子”的新范式 在生活和合成系统之间。购买仪器的购买是合理的 Mira提案，需求是合理的，设备成本在25万美元以内。在 家长R35 Mira约为90,000美元，不足以支付该乐器的购买。

项目成果

Amorphous entangled active matter

非晶态缠结活性物质

• DOI: 10.1039/d2sm01573k
• 发表时间: 2023
• 期刊: Soft Matter
• 影响因子: 3.4
• 作者: Savoie, William;Tuazon, Harry;Tiwari, Ishant;Bhamla, M. Saad;Goldman, Daniel I.
• 通讯作者: Goldman, Daniel I.

Oxygenation-Controlled Collective Dynamics in Aquatic Worm Blobs

水生蠕虫斑点中氧合控制的集体动力学

• DOI: 10.1093/icb/icac089
• 发表时间: 2022
• 期刊: Integrative and Comparative Biology
• 影响因子: 2.6
• 作者: Tuazon, Harry;Kaufman, Emily;Goldman, Daniel I.;Bhamla, M. Saad
• 通讯作者: Bhamla, M. Saad

The ultrafast snap of a finger is mediated by skin friction

• DOI: 10.1098/rsif.2021.0672
• 发表时间: 2021-11-17
• 期刊: JOURNAL OF THE ROYAL SOCIETY INTERFACE
• 影响因子: 3.9
• 作者: Acharya, Raghav;Challita, Elio J.;Bhamla, M. Saad
• 通讯作者: Bhamla, M. Saad

Air-to-land transitions: from wingless animals and plant seeds to shuttlecocks and bio-inspired robots

• DOI: 10.1088/1748-3190/acdb1c
• 发表时间: 2023-09-01
• 期刊: BIOINSPIRATION & BIOMIMETICS
• 影响因子: 3.4
• 作者: Ortega-Jimenez，Victor M.;Jusufi，Ardian;Bhamla，M. Saad
• 通讯作者: Bhamla，M. Saad

Ultrafast reversible self-assembly of living tangled matter

活体缠结物质的超快可逆自组装

• DOI: 10.1126/science.ade7759
• 发表时间: 2023
• 期刊: Science
• 影响因子: 56.9
• 作者: Patil, Vishal P.;Tuazon, Harry;Kaufman, Emily;Chakrabortty, Tuhin;Qin, David;Dunkel, Jörn;Bhamla, M. Saad
• 通讯作者: Bhamla, M. Saad