Pathology and Bio-analytics Core

该中心的主要目标是了解糖尿病的病理生理机制 肥胖和心血管并发症。生物分析核心是一个组成部分， 该中心将在COBRE第三阶段的发展中发挥关键作用。核心会将 为糖尿病标本提供严格和全面的生物分析服务。它将 提供具有实验设计和最先进技术专长的智力投入， 满足中心研究人员的需求。核心由一群杰出的科学家组成 在色谱、质谱、临床化学、心血管 生理学和糖尿病。核心主任Sanjay Srivastava博士拥有超过25个 多年的分析生物化学和病理学研究经验，血管炎症， 动脉粥样硬化和糖尿病。他将监督所有核心业务，并将与 中心研究人员和COBRE-supported试点项目负责人完成他们的分析 生物化学需要。Lorkiewicz博士，核心的技术总监， 小分子量化合物的稳定同位素标记和质谱分析。 他将协助中心研究人员进行代谢组学、巯基组学和其他研究。 色谱/质谱分析。斯里瓦斯塔瓦博士和洛凯维奇博士会提供人手 对初级研究人员进行生物分析测定的培训。在核心获得的训练将 促进他们成长为科学家，并扩大他们的技能库。核心是 配备了最先进的临床化学和分析生物化学设备， 位于迪利亚巴克斯特大楼除了满足COBRE的当前要求之外， 项目，核心将继续扩大其知识库和技术专业知识，以满足 中心未来的需求。核心的长期目标是成为一个独立的 能够为研究人员提供尖端病理学和生物分析服务的实体 对糖尿病和心血管病理生理学感兴趣。持续卓越的病理学 分析将促进合作，这不仅将在财政上帮助核心小组， 在防治糖尿病并发症方面取得进展。

Overarching goal of the Center is to understand the mechanisms of pathophysiology of diabetes and obesity and their cardiovascular complications. The Bioanalytics Core is an integral part of the Center and will play a key role in the evolution of COBRE in Phase III. The Core will render services for rigorous and comprehensive bioanalytical analysis of diabetic specimens. It will provide intellectual input with experimental design and state-of-the-art technical expertise to address the needs of Center investigators. The Core consists of a group of outstanding scientists with expertise in chromatography, mass spectrometry, clinical chemistry, cardiovascular physiology and diabetes. Director of the Core, Dr. Sanjay Srivastava has more than twenty five years of research experience in analytical biochemistry and pathology, vascular inflammation, atherosclerosis and diabetes. He will oversee all the Core operations and will work closely with Center investigators and COBRE-supported pilot project leaders to fulfill their analytical biochemistry needs. Dr. Lorkiewicz, technical director of the Core has extensive experience in stable isotope labeling and mass spectrometric analyses of small molecular weight compounds. He will assist the Center investigators with their metabolomics, mercapturomics and other chromatography/mass spectrometry analyses. Drs. Srivastava and Lorkiewicz will provide hands on training to junior investigators for bioanalytical assays. The training acquired at the Core will facilitate them to grow as scientists and expand their repertoire of technical skills. The Core is equipped with state-of-the-art clinical chemistry and analytical biochemistry equipment and is located in the Delia Baxter Building. In addition to address the current requirements of the COBRE projects, the Core will continue to expand its knowledgebase and technical expertise to satisfy the future needs of the Center. Long term goal of the Core is to become a fiscally independent entity capable of providing cutting-edge pathology and bio-analytical services to researchers interested in diabetes and cardiovascular pathophysiology. Continued excellence in pathological analyses will foster collaborations which will not only help the Core financially, but will also advance the field in combatting diabetic complications.