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Environmental Exposure and Cardiometabolic Disease

环境暴露与心血管代谢疾病

基本信息

批准号：
9904675
负责人：
Sanjay Srivastava
金额：
$ 137.89万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9904675
关键词：
Action Research Acute Advanced Development Affect Animal Experiments Animal Model Animals Area Atmosphere Attenuated Awareness Biological Biological Markers Cardiovascular Diseases Cause of Death Chemical Exposure Chemicals Chemistry Chronic Communities Community Outreach Complement Cost Measures Critical Pathways Data Decision Making Detection Development Devices Diabetes Mellitus Disease Disease Pathway Ecology Education and Outreach Ensure Environment Environmental Exposure Epidemic Epidemiology Etiology Evaluation Exposure to Fatty Liver Foundations Future Goals Hazardous Chemicals Hazardous Substances Hazardous Waste Sites Health Heart Diseases Human Incidence Industrialization Injury Investigation Knowledge Liver diseases Mass Spectrum Analysis Measures Medical Metabolism Methods Molecular Monitor Non-Insulin-Dependent Diabetes Mellitus Nutritional Nutritional status Obesity Pathway interactions Population Postdoctoral Fellow Predisposition Prevalence Private Sector Public Health Public Sector Research Research Infrastructure Research Personnel Research Project Grants Research Support Research Training Resources Risk Sampling Science Severities Site Superfund Techniques Technology Testing Therapeutic Intervention Time Tissue Sample Toxic effect Toxicity Tests Toxicology Training Training Programs Translational Research Universities Validation Work animal tissue base biobank cardiometabolism computer code data archive data management data sharing education resources experience exposed human population graduate student human population study human tissue innovation interest member metabolomics multidisciplinary new technology novel marker obesity development outreach program pollutant programs remediation repository resilience response superfund chemical superfund site tool translational medicine volatile organic compound

项目摘要

PROJECT SUMMARY (Overall) This proposal is to establish a Superfund Center at the University of Louisville. This Center will support research on the cardiometabolic effects of volatile organic chemicals (VOCs) that are of high relevance to the Superfund Program. Center investigators will conduct mode-of-action research to unravel critical pathways of toxicity and to identify toxicological end-points (cardiometabolic changes) of chemicals (VOCs) found at Superfund and related sites. Using high throughput metabolomic and mass spectrometry approaches, animal experiments and human population studies, Center investigations will aid in the discovery and validation of novel biomarkers of both exposure and cardiometabolic injury that would lay the foundation for future remediation strategies. These studies will employ state-of-the-art tools to develop pollutant atmospheres for animal exposure and to measure unique and sensitive biological endpoints reflective of cardiometabolic injury. In addition, work supported by the Center will lead to the development of new methods and devices for quantifying atmospheric levels of VOCs that will employ advanced technologies and offer precise, but low-cost measurements of hazardous waste sites. The major objectives of the Center are to conduct state-of-the-art research on the cardiometabolic toxicity of VOCs and to determine how they affect cardiometabolic disease (CMD) prevalence and severity in exposed populations. These studies will be complemented by mode-of-action mechanistic studies in animals to identify the molecular and cellular mechanisms that contribute to VOC toxicity. Center investigators will also identify specific conditions such as nutritional status and obesity and increase susceptibility to VOC toxicity and test therapeutic interventions that can attenuate acute and chronic cardiometabolic effects of VOC exposures. The findings of these studies will contribute to both the discovery and the validation of sensitive and robust biomarkers that could be used to assess the extent of exposure, metabolism and toxicity. Center investigators will create new technologies for detecting VOCs at low environmental levels to enable future exposure assessment activities. Senior Center members will educate and train junior investigators, graduate students and post-doctoral Fellows in the field of environmental science, and promote relevant community awareness and participation to enhance mutual bidirectional understanding of exposure risk and the health effects of exposure. The findings and discoveries of the Center will be transferred to affected communities, end users in public and private sectors, and other stakeholders. For future use and analysis, all samples of human and animal tissues and all data collected during Center investigations will be stored in a computer-coded biorepository. Collectively, Center activities will lead to rigorous evaluation and better understanding of the effects of these hazardous chemicals on obesity, diabetes and cardiovascular disease.

项目总结（总体）