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Pilot Innovation Core

试点创新核心

基本信息

批准号：
10454998
负责人：
STEVEN M KOGAN
金额：
$ 10.91万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454998
关键词：
Addictive Behavior Address Adolescence Adolescent Affect African American African American population Age Applications Grants Area Attenuated Award Behavioral Biological Process Brain Cancer Grant Supplements (P30)Cardiometabolic Disease Centers of Research Excellence Childhood Chronic stress Data Data Analyses Data Set Development Diet Habits Drug usage Eating Etiology Exposure to Family Feedback Fostering Foundations Functional Magnetic Resonance Imaging Funding Funding Mechanisms Future Generations Goals Grant Health Immune Immunology Individual Inflammation Inflammation Mediators Investigation Mediator of activation protein Mentors Mentorship Methodology Minority Modeling Monitor Neurobiology Neuroimmune Neurosciences Observational Study Peer Review Persons Pilot Projects Plant Roots Population Poverty Prevention Prevention program Prevention trial Preventive Process Publications Randomized Recording of previous events Research Research Personnel Research Training Resource-limited setting Resources Risk Role Sample Size Science Scientific Advances and Accomplishments Scientist Seeds System Training Underrepresented Populations Universities Work age group cardiometabolism career career development cohort contextual factors design drug abuse prevention drug development experience faculty mentor innovation insight interdisciplinary collaboration network models next generation novel novel strategies pedagogy programs psychosocial racial discrimination randomized trial ranpirnase recruit relating to nervous system research study resilience secondary analysis social adversity substance use substance use prevention success training project transmission process working group young adult

项目摘要

PROJECT SUMMARY: Pilot Core The Pilot Core of the proposed P50 supports the vitality of the Center by facilitating investigator development and promoting new research insights and priorities for the Center’s research studies. This program will provide a funding mechanism for pilot project applications from early career investigators (ECIs) and from established investigators seeking to extend their research into assessment of neural and inflammatory mediators of drug use and cardiometabolic health. Investigators can access seed grant funding and Center resources to (a) assess the feasibility of exploring a new research question, (b) apply a new approach, or (c) use existing methodology to explore a novel way to advance a new area of scientific exploration. The seed grant program also will provide resources to support secondary data analysis of CTAPS datasets from concluded and ongoing projects. These datasets were collected through both longitudinal, observational research and randomized prevention trials. Our datasets will permit replication of findings, comparison of models for different age groups (e.g., adolescents versus young adults), and aggregation of variables across data sets (harmonization) to maximize sample size or the age span to be evaluated. In addition to the investigator career development that occurs via seed grant funding, we propose to implement a targeted mentoring program for ECIs. Although not limited to minority or African American ECIs, an expressed goal of this program is to recruit early-career scientists from underrepresented backgrounds at UGA and our P50 partner, Northwestern University (NWU). This program is informed by CTAPS investigators’ experience with mentoring in the P30, a history of systematic mentoring for junior faculty, mentoring via diversity supplements, and implementing an Institutional Research Training Grant. To initiate the Year 1 (Y1) pilot project and mentoring system, we designed a unique pilot that will serve as a collaborative training experience for the Y1 mentoring cohort and advance the scientific aims of the Center. This experience centers around a secondary data analysis of fMRI, inflammation, and psychosocial data collected during the past CTAPS P30 grant period. The training cohort will work with this unique, rich data set under the guidance of Dr. Brody, the Center Director, with methodological and substantive support from P50 scientists and statisticians. The aims of our Pilot Core are to: (1) administer a seed grant program designed to support pilot projects that address African Americans’ drug use and cardiometabolic vulnerabilities; (2) provide targeted mentoring to early-career investigators, particularly those from underrepresented groups; and (3) implement a unique Year 1 pilot project/training experience: “Racial discrimination, protective processes, and drug use among African Americans: The role of NIN mechanisms.”

项目总结：试点核心