Pilot Innovation Core

试点创新核心

• 批准号: 10670883
• 负责人: STEVEN M KOGAN
• 金额: $ 10.91万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670883
• 关键词: Acceleration; Addictive Behavior; Address; Adolescence; Adolescent; Affect; African American; African American population; Age; Applications Grants; Area; Attenuated; Award; Behavioral; Biological Process; Brain; Cardiometabolic Disease; Center Core Grants; Centers of Research Excellence; Childhood; Chronic stress; Data; Data Analyses; Data Set; Development; Diet Habits; Drug usage; Eating; Etiology; Exposure to; Faculty; Family; Feedback; Fostering; Foundations; Functional Magnetic Resonance Imaging; Funding; Funding Mechanisms; Future; Generations; Goals; Grant; Health; Immune; Immunology; Individual; Inflammation; Inflammation Mediators; Institution; Investigation; Learning; Mediator; Mentors; Mentorship; Methodology; Minority; Modeling; Monitor; Neurobiology; Neuroimmune; Neurosciences; Observational Study; Peer Review; Persons; Pilot Projects; Population; Poverty; Prevention; Prevention program; Prevention trial; Preventive; Process; Publications; Randomized; Recording of previous events; Research; Research Personnel; Research Training; Resource-limited setting; Resources; Risk; Risk Factors; Role; Sample Size; Science; Scientific Advances and Accomplishments; Scientist; System; Training; Underrepresented Populations; Universities; Work; age group; cardiometabolism; career; career development; cohort; contextual factors; design; drug abuse prevention; drug development; experience; innovation; insight; interdisciplinary collaboration; network models; neural; next generation; novel; novel strategies; programs; psychosocial; racial discrimination; randomized trial; recruit; research study; resilience; resilience factor; secondary analysis; social adversity; substance use; substance use prevention; success; transmission process; working group; young adult

PROJECT SUMMARY: Pilot Core The Pilot Core of the proposed P50 supports the vitality of the Center by facilitating investigator development and promoting new research insights and priorities for the Center’s research studies. This program will provide a funding mechanism for pilot project applications from early career investigators (ECIs) and from established investigators seeking to extend their research into assessment of neural and inflammatory mediators of drug use and cardiometabolic health. Investigators can access seed grant funding and Center resources to (a) assess the feasibility of exploring a new research question, (b) apply a new approach, or (c) use existing methodology to explore a novel way to advance a new area of scientific exploration. The seed grant program also will provide resources to support secondary data analysis of CTAPS datasets from concluded and ongoing projects. These datasets were collected through both longitudinal, observational research and randomized prevention trials. Our datasets will permit replication of findings, comparison of models for different age groups (e.g., adolescents versus young adults), and aggregation of variables across data sets (harmonization) to maximize sample size or the age span to be evaluated. In addition to the investigator career development that occurs via seed grant funding, we propose to implement a targeted mentoring program for ECIs. Although not limited to minority or African American ECIs, an expressed goal of this program is to recruit early-career scientists from underrepresented backgrounds at UGA and our P50 partner, Northwestern University (NWU). This program is informed by CTAPS investigators’ experience with mentoring in the P30, a history of systematic mentoring for junior faculty, mentoring via diversity supplements, and implementing an Institutional Research Training Grant. To initiate the Year 1 (Y1) pilot project and mentoring system, we designed a unique pilot that will serve as a collaborative training experience for the Y1 mentoring cohort and advance the scientific aims of the Center. This experience centers around a secondary data analysis of fMRI, inflammation, and psychosocial data collected during the past CTAPS P30 grant period. The training cohort will work with this unique, rich data set under the guidance of Dr. Brody, the Center Director, with methodological and substantive support from P50 scientists and statisticians. The aims of our Pilot Core are to: (1) administer a seed grant program designed to support pilot projects that address African Americans’ drug use and cardiometabolic vulnerabilities; (2) provide targeted mentoring to early-career investigators, particularly those from underrepresented groups; and (3) implement a unique Year 1 pilot project/training experience: “Racial discrimination, protective processes, and drug use among African Americans: The role of NIN mechanisms.”

项目摘要：试点核心 拟议P50的试点核心通过促进调查员发展来支持中心的活力 并促进新的研究见解和中心研究的优先事项。该计划将提供 为早期职业调查员(ECI)和已建立的试点项目申请提供资金机制 寻求将他们的研究扩展到评估药物的神经和炎症介质的研究人员 使用和心脏代谢健康。研究人员可以获得种子赠款资金和中心资源，以(A) 评估探索新研究问题的可行性，(B)应用新方法，或(C)使用现有方法 探索一种新的方法来推进科学探索的新领域。种子资助计划 还将提供资源，支持对CONTAIND和 正在进行的项目。这些数据集是通过纵向、观察性研究和 随机预防试验。我们的数据集将允许复制研究结果，比较不同 年龄组(例如，青少年与年轻人)以及各数据集变量的汇总 (协调)最大化样本大小或要评估的年龄跨度。除了调查员的职业生涯 通过种子赠款资金进行的发展，我们建议实施一项有针对性的指导计划 ECIS。虽然不限于少数族裔或非裔美国人，但该计划的一个明确目标是招募 来自UGA和我们的P50合作伙伴西北大学背景不足的早期职业科学家 大学(西北大学)。本计划由CTAPS调查人员在P30中进行指导的经验提供信息，a 为初级教员提供系统指导的历史，通过多样化补充进行指导，以及实施 院校研究训练补助金。为推行一年(Y1)先导计划和导师制，我们 设计了一个独特的试点，将作为Y1指导队列的协作培训体验，并 推进中心的科学目标。这种体验围绕着fMRI的二次数据分析， 在过去的CTAPS P30赠款期间收集的炎症和心理社会数据。培训队伍将 在中心主任Brody博士的指导下，使用这个独特的、丰富的数据集，并采用 并得到P50科学家和统计学家的实质性支持。我们的试点核心的目标是：(1)管理 一项种子赠款计划，旨在支持解决非裔美国人吸毒和 心脏代谢脆弱性；(2)为职业生涯早期的研究人员提供有针对性的指导，特别是那些 来自代表性不足的群体；和(3)实施独特的第一年试点项目/培训经验：“种族 非裔美国人中的歧视、保护过程和药物使用：NIN机制的作用。