Pilot Innovation Core

试点创新核心

• 批准号: 10023723
• 负责人: STEVEN M KOGAN
• 金额: $ 11.86万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023723
• 关键词: Addictive Behavior; Address; Adolescence; Adolescent; Affect; African American; Age; Alcohol or Other Drugs use; Applications Grants; Area; Attenuated; Award; Behavioral; Biological Process; Brain; Cancer Grant Supplements (P30); Centers of Research Excellence; Childhood; Chronic stress; Communities; Data; Data Analyses; Data Set; Development; Diet Habits; Disease; Drug usage; Eating; Etiology; Exposure to; Family; Feedback; Fostering; Foundations; Functional Magnetic Resonance Imaging; Funding; Funding Mechanisms; Future; Generations; Goals; Grant; Health; Immune; Immunology; Individual; Inflammation; Inflammation Mediators; Investigation; Mediator of activation protein; Mentors; Mentorship; Methodology; Minority; Modeling; Monitor; Neurobiology; Neuroimmune; Neurosciences; Observational Study; Peer Review; Pilot Projects; Plant Roots; Population; Poverty; Prevention; Prevention program; Prevention trial; Preventive; Process; Publications; Randomized; Recording of previous events; Research; Research Personnel; Research Training; Resources; Risk; Role; Sample Size; Science; Scientific Advances and Accomplishments; Scientist; Seeds; System; Training; Underrepresented Groups; Universities; Work; age group; cardiometabolism; career; career development; cohort; contextual factors; design; drug abuse prevention; drug development; experience; faculty mentor; innovation; insight; interdisciplinary collaboration; network models; next generation; novel; novel strategies; pedagogy; programs; psychosocial; racial discrimination; randomized trial; ranpirnase; recruit; relating to nervous system; research study; resilience; secondary analysis; social; substance use prevention; success; training project; transmission process; working group; young adult

PROJECT SUMMARY: Pilot Core The Pilot Core of the proposed P50 supports the vitality of the Center by facilitating investigator development and promoting new research insights and priorities for the Center’s research studies. This program will provide a funding mechanism for pilot project applications from early career investigators (ECIs) and from established investigators seeking to extend their research into assessment of neural and inflammatory mediators of drug use and cardiometabolic health. Investigators can access seed grant funding and Center resources to (a) assess the feasibility of exploring a new research question, (b) apply a new approach, or (c) use existing methodology to explore a novel way to advance a new area of scientific exploration. The seed grant program also will provide resources to support secondary data analysis of CTAPS datasets from concluded and ongoing projects. These datasets were collected through both longitudinal, observational research and randomized prevention trials. Our datasets will permit replication of findings, comparison of models for different age groups (e.g., adolescents versus young adults), and aggregation of variables across data sets (harmonization) to maximize sample size or the age span to be evaluated. In addition to the investigator career development that occurs via seed grant funding, we propose to implement a targeted mentoring program for ECIs. Although not limited to minority or African American ECIs, an expressed goal of this program is to recruit early-career scientists from underrepresented backgrounds at UGA and our P50 partner, Northwestern University (NWU). This program is informed by CTAPS investigators’ experience with mentoring in the P30, a history of systematic mentoring for junior faculty, mentoring via diversity supplements, and implementing an Institutional Research Training Grant. To initiate the Year 1 (Y1) pilot project and mentoring system, we designed a unique pilot that will serve as a collaborative training experience for the Y1 mentoring cohort and advance the scientific aims of the Center. This experience centers around a secondary data analysis of fMRI, inflammation, and psychosocial data collected during the past CTAPS P30 grant period. The training cohort will work with this unique, rich data set under the guidance of Dr. Brody, the Center Director, with methodological and substantive support from P50 scientists and statisticians. The aims of our Pilot Core are to: (1) administer a seed grant program designed to support pilot projects that address African Americans’ drug use and cardiometabolic vulnerabilities; (2) provide targeted mentoring to early-career investigators, particularly those from underrepresented groups; and (3) implement a unique Year 1 pilot project/training experience: “Racial discrimination, protective processes, and drug use among African Americans: The role of NIN mechanisms.”

项目概要：中试核心 拟议P50的试点核心通过促进研究者发展来支持中心的活力 并促进新的研究见解和中心的研究重点。该计划将提供 为早期职业调查员和已建立的 研究人员试图将他们的研究扩展到药物的神经和炎症介质的评估， 使用和心脏代谢健康。研究者可以获得种子基金和中心资源，以（a） 评估探索新研究问题的可行性，（B）应用新方法，或（c）使用现有的 方法论，探索一种新的方式，推进科学探索的新领域。种子基金项目 还将提供资源，以支持对CTAPS数据集的二级数据分析， 正在进行的项目。这些数据集是通过纵向、观察性研究和 随机预防试验。我们的数据集将允许复制发现、比较不同模型 年龄组（例如，青少年与年轻人），以及数据集变量的汇总 （协调）以最大限度地扩大样本量或待评价的年龄跨度。除了调查员的职业生涯 通过种子赠款资金发生的发展，我们建议实施有针对性的指导计划， ECIs。虽然不限于少数民族或非洲裔美国人的ECIs，但该计划的明确目标是招募 来自UGA和我们的P50合作伙伴西北大学代表性不足的背景的早期职业科学家 大学（NWU）。该计划是由CTAPS调查人员在P30指导的经验， 对初级教师进行系统指导的历史，通过多样性补充进行指导，并实施 机构研究培训补助金。为了启动一年级试点项目和导师制，我们 设计了一个独特的试点，将作为一个合作的培训经验，为Y1辅导队列， 促进中心的科学目标。这个经验围绕着功能磁共振成像的二级数据分析， 炎症，以及在过去的CTAPS P30资助期间收集的心理社会数据。培训班将 在中心主任Brody博士的指导下，我使用这个独特而丰富的数据集， 以及P50科学家和统计学家的实质性支持。我们的试点核心的目标是：（1）管理 一项种子赠款计划，旨在支持解决非洲裔美国人吸毒问题的试点项目， 心脏代谢脆弱性;（2）为早期职业调查人员提供有针对性的指导，特别是那些 从代表性不足的群体;和（3）实施一个独特的第一年试点项目/培训经验： 歧视，保护过程和非裔美国人的药物使用：NIN机制的作用。