United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers

美国-东非艾滋病毒相关恶性肿瘤研究中心 (USEAHAMRC)，致力于职业发展以及病毒相关癌症的预防、早期检测和有效护理联系

• 批准号: 10454919
• 负责人: Andrew Ddungu Kambugu
• 金额: $ 25.51万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454919
• 关键词: AIDS related cancer; Address; Africa; Africa South of the Sahara; African; Award; Back; Biometry; California; Caring; Clinical; Clinical Research; Collaborations; Communicable Diseases; Country; Development; Diagnosis; Diagnostic tests; Early Diagnosis; Early treatment; Face; Foundations; Funding; General Hospitals; General Population; HIV; HIV Infections; Health; Home; Incidence; Individual; Institutes; Institution; Junior Physician; K-Series Research Career Programs; Kaposi Sarcoma; Kenya; Knowledge; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Massachusetts; Mediating; Medical Research; Mentors; Modeling; Patients; Performance; Persons; Pilot Projects; Prevention; Prevention strategy; Primary Prevention; Principal Investigator; Prognosis; Program Development; Public Health; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource-limited setting; Resources; San Francisco; Science; Scientist; Screening for cancer; Secondary Prevention; Shoulder; Structure; Tanzania; Training; Translational Research; Uganda; United States; United States National Institutes of Health; United States National Library of Medicine; Universities; Viral; Work; advanced disease; anticancer research; base; career development; cervical cancer prevention; clinically relevant; data management; epidemiology study; experience; improved; interest; novel; operation; programs; prospective; research study; response; screening; tool; virus related cancer

In the field of HIV-associated malignancies, East Africa faces three intersecting problems common to resource-limited settings. First, East Africa lacks effective primary and secondary prevention strategies for cervical cancer and Kaposi’s sarcoma (KS), two of the most common cancers not only among HIV-infected persons but in the general population. Survival for both malignancies is poor due to multiple factors including lack of screening, advanced disease stage at presentation, suboptimal diagnostic tests and fragile linkage to care. Second, there is a paucity of local principal investigators to lead research related to HIV- associated cancer. Third, there are no robust research networks to study primary and secondary prevention of HIV-associated cancers in the region. To address this, eight institutions in the U.S. and East Africa will: Aim 1. Create a collaborative network of U.S.-based and East African-based scientists and institutions — the United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) — focused on career development and the performance of research related to prevention, early detection and efficient linkage to care for virus-related cancers; Aim 2. Support the career development of emerging African principal investigators, U.S.-based junior investigators and others in the USEAHAMRC in the performance of HIV and other virus- related cancer research; and Aim 3. Conduct novel research — led by our emerging African principal investigators — related to the prevention, early detection and efficient linkage to care for virus-related cancers. The USEAHAMRC will build on prior work in U54 CA190153 to create a network of scientists from 4 U.S. institutions (UCSF, Duke, Massachusetts General Hospital, and the National Library of Medicine) and 4 African institutions in 3 East African countries (Infectious Diseases Institute in Uganda; Moi University in Kenya; Kenya Medical Research Institute; and Muhimbili University in Tanzania) (Aim 1). We will model our career development activities after NIH-sponsored institutional mentored career development programs (Aim 2). Managed by a Developmental Core, these activities will include professional enrichment to all interested junior scientists at our participating institutions, mentoring of a select group of African and U.S.- based junior scientists to compete for career development awards, and a Pilot Project program to attract new junior scientists. Our African junior investigators will also lead two research projects (Aim 3): Project 1, A Public Health Approach to Cervical Cancer Prevention in East Africa; and Project 2, Rapid Case Ascertainment as a Tool for Epidemiologic Investigation and Efficient Linkage to Care in HIV-infected Patients Diagnosed with Kaposi Sarcoma in East Africa. A Data Management and Biostatistical Analysis Core (DMBAC) will support all of the science. Finally, an Administrative Core will oversee all operations.

在艾滋病毒相关的恶性肿瘤领域，东非面临着三个共同的交叉问题， 资源有限的环境。首先，东非缺乏有效的初级和二级预防战略， 宫颈癌和卡波西肉瘤（KS），这两种最常见的癌症不仅在艾滋病毒感染者中， 人，但在一般人群中。由于多种因素，这两种恶性肿瘤的生存率都很低 包括缺乏筛查、就诊时疾病处于晚期、诊断测试不佳和脆弱 联系关怀。其次，缺乏当地的主要研究人员来领导与艾滋病毒有关的研究， 相关癌症第三，没有强有力的研究网络来研究初级和二级预防 艾滋病相关的癌症。为了解决这个问题，美国和东非的八个机构将： 目标1。建立一个美国的合作网络-总部和东非的科学家， 美国-东非艾滋病毒相关研究中心 （USEAHAMRC）-专注于职业发展和与研究相关的绩效 预防、早期发现和有效联系与病毒有关的癌症的护理; 目标2.支持新兴非洲主要研究者的职业发展，美国-基于 初级研究人员和其他在USEAHAMRC在艾滋病毒和其他病毒的性能- 相关癌症研究;以及 目标3.进行新的研究-由我们新兴的非洲主要研究者领导-相关 预防、早期发现和有效联系到与病毒有关的癌症的护理。 USEAHAMRC将在U 54 CA 190153的基础上建立一个由来自美国4个国家的科学家组成的网络。 机构（UCSF，杜克，马萨诸塞州总医院和国家医学图书馆）和4 3个东非国家的非洲机构（乌干达传染病研究所;莫伊大学 肯尼亚、肯尼亚医学研究所和坦桑尼亚穆欣比利大学）（目标1）。我们将以我们的 NIH赞助的机构辅导职业发展计划后的职业发展活动 (Aim 2）。由发展核心管理，这些活动将包括专业充实所有 在我们的参与机构感兴趣的初级科学家，指导一组选定的非洲和美国- 的初级科学家竞争职业发展奖，以及试点项目计划，以吸引 新的年轻科学家我们的非洲初级研究人员还将领导两个研究项目（目标3）：项目1， 东非预防宫颈癌的公共卫生方法;项目2，快速病例 艾滋病病毒感染者的流行病学调查和有效的护理联系的工具--艾滋病病毒感染者的确认 东非的卡波西肉瘤患者。数据管理和生物统计分析 核心（DMBAC）将支持所有的科学。最后，一个行政核心将监督所有业务。