United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers

美国-东非艾滋病毒相关恶性肿瘤研究中心 (USEAHAMRC)，致力于职业发展以及病毒相关癌症的预防、早期检测和有效护理联系

• 批准号: 10454919
• 负责人: Andrew Ddungu Kambugu
• 金额: $ 25.51万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454919
• 关键词: AIDS related cancer; Address; Africa; Africa South of the Sahara; African; Award; Back; Biometry; California; Caring; Clinical; Clinical Research; Collaborations; Communicable Diseases; Country; Development; Diagnosis; Diagnostic tests; Early Diagnosis; Early treatment; Face; Foundations; Funding; General Hospitals; General Population; HIV; HIV Infections; Health; Home; Incidence; Individual; Institutes; Institution; Junior Physician; K-Series Research Career Programs; Kaposi Sarcoma; Kenya; Knowledge; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Massachusetts; Mediating; Medical Research; Mentors; Modeling; Patients; Performance; Persons; Pilot Projects; Prevention; Prevention strategy; Primary Prevention; Principal Investigator; Prognosis; Program Development; Public Health; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource-limited setting; Resources; San Francisco; Science; Scientist; Screening for cancer; Secondary Prevention; Shoulder; Structure; Tanzania; Training; Translational Research; Uganda; United States; United States National Institutes of Health; United States National Library of Medicine; Universities; Viral; Work; advanced disease; anticancer research; base; career development; cervical cancer prevention; clinically relevant; data management; epidemiology study; experience; improved; interest; novel; operation; programs; prospective; research study; response; screening; tool; virus related cancer

In the field of HIV-associated malignancies, East Africa faces three intersecting problems common to resource-limited settings. First, East Africa lacks effective primary and secondary prevention strategies for cervical cancer and Kaposi’s sarcoma (KS), two of the most common cancers not only among HIV-infected persons but in the general population. Survival for both malignancies is poor due to multiple factors including lack of screening, advanced disease stage at presentation, suboptimal diagnostic tests and fragile linkage to care. Second, there is a paucity of local principal investigators to lead research related to HIV- associated cancer. Third, there are no robust research networks to study primary and secondary prevention of HIV-associated cancers in the region. To address this, eight institutions in the U.S. and East Africa will: Aim 1. Create a collaborative network of U.S.-based and East African-based scientists and institutions — the United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) — focused on career development and the performance of research related to prevention, early detection and efficient linkage to care for virus-related cancers; Aim 2. Support the career development of emerging African principal investigators, U.S.-based junior investigators and others in the USEAHAMRC in the performance of HIV and other virus- related cancer research; and Aim 3. Conduct novel research — led by our emerging African principal investigators — related to the prevention, early detection and efficient linkage to care for virus-related cancers. The USEAHAMRC will build on prior work in U54 CA190153 to create a network of scientists from 4 U.S. institutions (UCSF, Duke, Massachusetts General Hospital, and the National Library of Medicine) and 4 African institutions in 3 East African countries (Infectious Diseases Institute in Uganda; Moi University in Kenya; Kenya Medical Research Institute; and Muhimbili University in Tanzania) (Aim 1). We will model our career development activities after NIH-sponsored institutional mentored career development programs (Aim 2). Managed by a Developmental Core, these activities will include professional enrichment to all interested junior scientists at our participating institutions, mentoring of a select group of African and U.S.- based junior scientists to compete for career development awards, and a Pilot Project program to attract new junior scientists. Our African junior investigators will also lead two research projects (Aim 3): Project 1, A Public Health Approach to Cervical Cancer Prevention in East Africa; and Project 2, Rapid Case Ascertainment as a Tool for Epidemiologic Investigation and Efficient Linkage to Care in HIV-infected Patients Diagnosed with Kaposi Sarcoma in East Africa. A Data Management and Biostatistical Analysis Core (DMBAC) will support all of the science. Finally, an Administrative Core will oversee all operations.

在艾滋病毒相关恶性肿瘤领域，东非面临三个共同的交叉问题 资源受限设置。首先，东非缺乏有效的初级和二级预防战略。 宫颈癌和卡波西肉瘤(KS)，这两种最常见的癌症不仅在艾滋病毒感染者中 而不是在普通人群中。由于多种因素，这两种恶性肿瘤的存活率都很低。 包括缺乏筛查、出现晚期疾病、诊断测试不够理想和脆弱 与护理挂钩。其次，当地缺乏领导与艾滋病毒相关的研究的主要调查人员。 相关癌症。第三，没有强有力的研究网络来研究一级和二级预防 在该地区与艾滋病毒相关的癌症中。为了解决这一问题，美国和东非的八家机构将： 目标1.创建美国和东非科学家和 机构-美国-东非艾滋病毒相关恶性肿瘤研究中心 (USEAHAMRC)-专注于职业发展和与以下相关的研究表现 预防、早期发现和有效联系，以照顾与病毒相关的癌症； 目标2.支持非洲新兴首席调查员的职业发展，常驻美国 初级调查人员和USEAHAMRC中的其他人对艾滋病毒和其他病毒的表现- 相关的癌症研究；以及 目标3.开展新的研究--由我们新兴的非洲首席调查人员领导--与 到预防、早期发现和有效联系，以照顾与病毒相关的癌症。 USEAHAMRC将在U54 CA190153先前工作的基础上，创建一个来自美国4个国家的科学家网络。 机构(加州大学旧金山分校、杜克大学、马萨诸塞州总医院和国家医学图书馆)和4 3个东非国家的非洲机构(乌干达传染病研究所；#年莫伊大学 (肯尼亚、肯尼亚医学研究所和坦桑尼亚穆亨比利大学)(目标1)。我们将为我们的 美国国立卫生研究院资助的机构辅导职业发展计划后的职业发展活动 (目标2)。由发展核心管理，这些活动将包括对所有人的专业充实 我们参与机构的感兴趣的初级科学家，指导一批精选的非洲和美国人- 以初级科学家为基础竞争职业发展奖，并推出试点项目计划以吸引 新的初级科学家。我们的非洲初级调查人员还将领导两个研究项目(目标3)：项目1， 东非预防宫颈癌的公共卫生方法；和项目2，快速病例 确定作为流行病学调查和有效联系艾滋病毒感染者护理的工具 东非被诊断为卡波西肉瘤的患者。数据管理与生物统计分析 CORE(DMBAC)将支持所有的科学。最后，行政核心将监督所有业务。