Developmental Core

培养一名独立科学家需要在丰富的学术环境中进行广泛的培训，因为 以及为实习生提供足够的工资和研究支持。受教育的毕业生之后的时期 培训在东非特别脆弱，在整个撒哈拉以南非洲也是如此。而当 研究生培训存在资金来源，该区域缺乏全面的机制来支持初级 研究人员正在向研究独立过渡。在美国，研究生培训通常是 由美国国立卫生研究院个人和机构层面的“K奖”项目推动。美国国立卫生研究院K奖一直是 非洲科学家无法使用，但最近随着K43 Emerging Global的创建，这种情况发生了变化 领袖奖。然而，为学员和他们的家庭做好准备仍然是一个巨大的挑战 竞争K43奖项或其他职业发展奖项的机构。为了满足以下需求 职业发展在研究生阶段，USEAHAMRC的发展核心将： 目标1.加强临床、流行病学和职业发展的整体环境 我们美国东非机构的翻译研究-东非艾滋病毒- 联合恶性肿瘤研究中心(USEAHAMRC)。 目标2.为我们新兴的非洲和美国初级科学家提供指导和保护时间 在艾滋病毒相关恶性肿瘤领域工作，因为他们发展了自己的学术和 领导力组合成熟，走向独立。 目标3.为新兴非洲或美国开展的试点研究项目提供资金 科学家。 仿照美国的机构K奖项目，我们将创建半月职业发展 以科学写作、指导技能和基本方法培训为重点的研讨会 面向我们参与机构的所有感兴趣的学者(目标1)。通过借鉴从K 在美国获得资金，四名新兴的乌干达主要调查人员将获得相当大一部分 他们的时间支持在艾滋病毒相关恶性肿瘤领域进行研究，并将 指导他们竞争资金，以推动他们进入职业生涯的下一个阶段(目标2)。与 在加州大学旧金山分校大量机构承诺的帮助下，我们将授予两到三个试点项目 在与USEAHAMRC研究主题相关的研究的5年资助周期内每年颁发奖项， 这将帮助我们识别和指导下一批初级调查员。

Creating an independent scientist requires extensive training within an enriching academic environment as well as adequate salary and research support for the trainee. The period that follows didactic graduate training is particularly vulnerable in East Africa, which is also true in sub-Saharan Africa as a whole. While funding streams exist for graduate training, the region lacks comprehensive mechanisms to support junior investigators as they transition towards research independence. In the U.S., post-graduate training is often facilitated by NIH "K Award" programs at both the individual and institutional level. NIH K Awards had been unavailable to African scientists but this recently changed with the creation of the K43 Emerging Global Leader Award. Yet, there still remains a substantial challenge preparing both trainees and their home institutions to compete for a K43 Award or other career development awards. To address the need for career development in the post-graduate period, the Developmental Core of the USEAHAMRC will: Aim 1. Bolster the overall environment for career development in clinical, epidemiologic and translational research at the East African institutions of our United States-East Africa HIV- Associated Malignancy Research Center (USEAHAMRC). Aim 2. Mentor and provide protected time for our emerging African and U.S. junior scientists working in the field of HIV-associated malignancies as they develop their academic and leadership portfolio and mature towards independence. Aim 3. Award funding for pilot research projects to be conducted by emerging African or U.S scientists. Modeled on institutional K Award programs in the U.S., we will create a semi-monthly Career Development Seminar featuring emphasis on scientific writing, mentorship skills, and foundational methodologic training for all interested scholars at our participating institutions (Aim 1). By drawing upon lessons learned from K Award funding in the U.S., four emerging Ugandan principal investigators will have a substantial portion of their time supported for the conduct of research in area of HIV-associated malignancies and will be mentored to compete for funding that will propel them to the next stage of their careers (Aim 2). With the assistance from substantial institutional commitment from UCSF, we will award two or three Pilot Project Awards annually over the 5-year funding cycle for research related to the USEAHAMRC research themes, which will help us identify and mentor the next cohort of junior investigators.