PAS GRAS: DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

PAS GRAS旨在预防和逆转四个年龄组的肥胖及相关代谢并发症：青春期前儿童（3-9岁）、青少年（10-18岁）、年轻人（19-25岁）和成年人（25-55岁）。PAS GRAS主要关注四大支柱。1)开发个性化风险评估工具（RAT）：一种预测关键年龄组肥胖启动和发展的算法，并确定随后几年特定并发症的危险因素，这些因素将构成介入研究的新结果。2)开发和实施基于rat的个性化干预措施，通过整合非药物生活方式改变，包括单独的地中海饮食成分或合理的针对代谢和神经内分泌机制的药物。3)通过联合制作创造性和互动式数字工具（包括简易版的RAT）以及个性化的饮食和体育活动计划，有效地向目标群体宣传肥胖的原因、风险和干预措施。4)通过与保健中心、学校、体育俱乐部、市政当局以及其他相关行为者和公共当局制定保健和食品/营养知识普及及体育活动联合方案，扩大和巩固整个欧洲量身定制的PAS GRAS运动。PAS GRAS结果将有助于在2050年之前使欧盟成人超重/肥胖患病率长期降低15%，儿童/青少年肥胖率长期降低30%，有助于减少肥胖相关并发症、药物和手术干预，并促进地中海饮食成为更有营养和可持续发展的未来的工具。PAS GRAS是一个独特的多学科和跨学科的研究团队，来自8个国家，包括12所顶级大学和研究机构。非学术伙伴包括一个民间组织、一家公司、一个病人组织和一个泛欧研究协会。

PAS GRAS aims to prevent and reverse obesity and associated metabolic complications in four age groups: pre-pubertal children (3-9 yr), adolescents (10-18 yr), young adults (19-25 yr), and adults (25-55). PAS GRAS focuses on four main pillars. 1) Develop a personalized risk assessment tool (RAT): an algorithm that will anticipate obesity priming and development in the critical age groups, and identify risk factors for specific complications in subsequent years that will constitute new outcomes for interventional studies. 2) Develop and implement RAT-based personalized interventions by integrating non-pharmacological lifestyle modifications including Mediterranean Diet components alone or with rational pharmacological targeting metabolic and neuroendocrine mechanisms. 3) Inform and engage effectively target groups on obesity causes, risks and intervention by co-production of creative and interactive digital tools (including a simpler version of the RAT) and personalized diet and physical activity programs. 4) Expand and consolidate the PAS GRAS tailor-made campaign across Europe through developing joint programs for health and food/nutrition literacy and physical activity, with healthcare centres, schools, sports clubs, municipalities, and other relevant actors and public authorities. PAS GRAS outcomes will contribute to a long-term 15% decrease in overweight/obesity prevalence in adults and 30% in children/adolescents in the EU until 2050, contributing to a downstream reduction of obesity-associated complications, pharmaceutical and surgical interventions, and to promote Mediterranean Diet as tool for a more nutritious and sustainable future. PAS GRAS is a unique multi- and interdisciplinary research team from 8 countries, including 12 top-level Universities and Research Institutions. Non-academic partners include a civil organization, one company, one patient organization and one Pan-European research Society.