Core A - Chemigenomics

核心 A - 化学基因组学

• 批准号: 10456890
• 负责人: Eric J. Rubin
• 金额: $ 35.48万
• 依托单位: TEXAS A&M AGRILIFE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456890
• 关键词: Animals; Biological; Biological Assay; Biological Process; CRISPR interference; Cells; Cellular Assay; Complex; Essential Genes; Genetic; Genetic Polymorphism; Genomic approach; Genomics; Genus Mycobacterium; Growth; Health Services Accessibility; Individual; Infection; Informatics; Methods; Molecular; Mus; Mutation; Phenotype; Play; Process; Proteins; Resistance; Resources; Role; Services; Structure; Structure-Activity Relationship; Validation; adjudicate; base; drug development; genetic approach; genetic variant; genome analysis; genome sequencing; in vivo; inhibitor; insight; knock-down; mutant; mycobacterial; overexpression; programs; protein function; screening; small molecule; small molecule inhibitor; small molecule libraries; tool; whole genome

Project Summary – Core A – Chemigenomics The TBSGC is focused on using structure to understand the molecular basis of biological function and to contribute to drug development. Core A plays a central role in multiple aspects of the program by: prioritizing vulnerable targets, generating mycobacterial mutants for structure-function studies, identifying small molecule inhibitors and determining the targets of inhibitors cells via whole-genome sequencing of resistant mutants. Each of these services are provided by labs with unique expertise in both the methods required and the biological insights that can result from their use.

项目概要-核心A -化学基因组学 TBSGC专注于使用结构来理解生物功能的分子基础， 有助于药物开发。核心A通过以下方式在该计划的多个方面发挥核心作用： 优先考虑脆弱的目标，产生分枝杆菌突变体用于结构-功能研究， 小分子抑制剂和通过全基因组测序确定抑制剂细胞的靶点， 抗性突变体这些服务中的每一项都由在这两种方法中具有独特专业知识的实验室提供 所需的和生物学的见解，可以从他们的使用。