Core A - Chemigenomics
Core A - Chemigenomics
批准号:
10456890
负责人:
Eric J. Rubin
金额:
$35.48万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-09-01 至 2024-07-31
关键词:
AnimalsBiologicalBiological AssayBiological ProcessCRISPR interferenceCellsCellular AssayComplexEssential GenesGeneticGenetic PolymorphismGenomic approachGenomicsGenus MycobacteriumGrowthHealth Services AccessibilityIndividualInfectionInformaticsMethodsMolecularMusMutationPhenotypePlayProcessProteinsResistanceResourcesRoleServicesStructureStructure-Activity RelationshipValidationadjudicatebasedrug developmentgenetic approachgenetic variantgenome analysisgenome sequencingin vivoinhibitorinsightknock-downmutantmycobacterialoverexpressionprogramsprotein functionscreeningsmall moleculesmall molecule inhibitorsmall molecule librariestoolwhole genome
中文摘要
项目概要-核心A -化学基因组学
TBSGC专注于使用结构来理解生物功能的分子基础,
有助于药物开发。核心A通过以下方式在该计划的多个方面发挥核心作用:
优先考虑脆弱的目标,产生分枝杆菌突变体用于结构-功能研究,
小分子抑制剂和通过全基因组测序确定抑制剂细胞的靶点,
抗性突变体这些服务中的每一项都由在这两种方法中具有独特专业知识的实验室提供
所需的和生物学的见解,可以从他们的使用。
英文摘要
Project Summary – Core A – Chemigenomics
The TBSGC is focused on using structure to understand the molecular basis of biological function and to
contribute to drug development. Core A plays a central role in multiple aspects of the program by:
prioritizing vulnerable targets, generating mycobacterial mutants for structure-function studies, identifying
small molecule inhibitors and determining the targets of inhibitors cells via whole-genome sequencing of
resistant mutants. Each of these services are provided by labs with unique expertise in both the methods
required and the biological insights that can result from their use.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Using genetics and multi-scale imaging to understand the mechanisms underlying mycobacteriophage host choice
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批准号:10308509
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项目类别:
-
资助金额:$19.72万
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财政年份:2020
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负责人:Eric J. Rubin
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依托单位:
Discovery of inhibitors that target the Mtb ClpP1P2 protease
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批准号:10595583
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项目类别:
-
资助金额:$43.49万
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财政年份:2019
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负责人:Eric J. Rubin
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依托单位:
Discovery of inhibitors that target the Mtb ClpP1P2 protease
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批准号:10388413
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项目类别:
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资助金额:$85.09万
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财政年份:2019
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负责人:Eric J. Rubin
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依托单位:
Core A - Chemigenomics
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批准号:10242860
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项目类别:
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资助金额:$36.0万
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财政年份:2012
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负责人:Eric J. Rubin
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依托单位:
Structures of Mtb proteins conferring susceptibility to known Mtb inhibitors
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批准号:8153416
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项目类别:
-
资助金额:$24.01万
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财政年份:2010
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负责人:Eric J. Rubin
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依托单位:
Drug Targets for Tuberculosis
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批准号:7418764
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项目类别:
-
资助金额:$40.61万
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财政年份:2009
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负责人:Eric J. Rubin
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依托单位:
2009 Tuberculosis Drug Development GRC
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批准号:7666385
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项目类别:
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资助金额:$1.65万
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财政年份:2009
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负责人:Eric J. Rubin
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依托单位:
Drug Targets for Tuberculosis
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批准号:7835731
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项目类别:
-
资助金额:$39.55万
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财政年份:2009
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负责人:Eric J. Rubin
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依托单位:
2007 GRC on TB Drug Development
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批准号:7268245
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项目类别:
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资助金额:$1.7万
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财政年份:2007
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负责人:Eric J. Rubin
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依托单位:
Drug resistance in tuberculosis: genetic and dynamics
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批准号:6649218
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项目类别:
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资助金额:$48.54万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Virulence Factors in Mycobacteria
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批准号:6400540
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项目类别:
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资助金额:$38.43万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Virulence Factors in Mycobacteria
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批准号:6632363
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项目类别:
-
资助金额:$36.41万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Drug resistance in tuberculosis: genetic and dynamics
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批准号:6922037
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项目类别:
-
资助金额:$48.54万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Virulence Factors in Mycobacteria
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批准号:6744338
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项目类别:
-
资助金额:$36.41万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Drug resistance in tuberculosis: genetic and dynamics
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批准号:6744152
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项目类别:
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资助金额:$48.54万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Virulence Factors in Mycobacteria
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批准号:6895515
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项目类别:
-
资助金额:$36.41万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Drug resistance in tuberculosis--Genetic and dynamics
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批准号:6411394
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项目类别:
-
资助金额:$48.55万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Virulence Factors in Mycobacteria
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批准号:6511401
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项目类别:
-
资助金额:$36.41万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Drug resistance in tuberculosis: genetic and dynamics
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批准号:6534387
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项目类别:
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资助金额:$41.26万
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财政年份:2001
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负责人:Eric J. Rubin
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依托单位:
Immunology and Infectious Diseases
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批准号:8511535
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项目类别:
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资助金额:$18.16万
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财政年份:2000
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负责人:Eric J. Rubin
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依托单位:
海外基金