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Core A - Chemigenomics

Core A - Chemigenomics
核心 A - 化学基因组学
批准号：
10242860
负责人：
Eric J. Rubin
金额：
$36.0万
依托单位：
TEXAS A&M AGRILIFE RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-09-01 至 2023-07-31
来源：
https://reporter.nih.gov/project-details/10242860
关键词：
AnimalsBiologicalBiological AssayBiological ProcessCRISPR interferenceCellsCellular AssayComplexEssential GenesGeneticGenetic PolymorphismGenomic approachGenomicsGenus MycobacteriumGrowthHealth Services AccessibilityIndividualInfectionInformaticsMethodsMolecularMusMutationPhenotypePlayProcessProteinsResistanceResourcesRoleServicesStructureStructure-Activity RelationshipValidationadjudicatebasedrug developmentgenetic approachgenetic variantgenome analysisgenome sequencingin vivoinhibitor/antagonistinsightknock-downmutantmycobacterialoverexpressionprogramsprotein functionscreeningsmall moleculesmall molecule inhibitorsmall molecule librariestoolwhole genome

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Project Summary – Core A – Chemigenomics The TBSGC is focused on using structure to understand the molecular basis of biological function and to contribute to drug development. Core A plays a central role in multiple aspects of the program by: prioritizing vulnerable targets, generating mycobacterial mutants for structure-function studies, identifying small molecule inhibitors and determining the targets of inhibitors cells via whole-genome sequencing of resistant mutants. Each of these services are provided by labs with unique expertise in both the methods required and the biological insights that can result from their use.
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Using genetics and multi-scale imaging to understand the mechanisms underlying mycobacteriophage host choice
  • 批准号：
    10308509
  • 项目类别：
  • 资助金额：
    $19.72万
  • 财政年份：
    2020
  • 负责人：
    Eric J. Rubin
  • 依托单位：
    HARVARD SCHOOL OF PUBLIC HEALTH
Discovery of inhibitors that target the Mtb ClpP1P2 protease
Discovery of inhibitors that target the Mtb ClpP1P2 protease
Core A - Chemigenomics
  • 批准号：
    10456890
  • 项目类别：
  • 资助金额：
    $35.48万
  • 财政年份：
    2012
  • 负责人：
    Eric J. Rubin
  • 依托单位：
    TEXAS A&M AGRILIFE RESEARCH
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