Children's Oncology Group NCI Community Oncology Research Program (NCORP) Research Base grant

项目摘要 在过去的几十年里，患有癌症的儿童的预后有了显著的改善，总体来说是5年 存活率目前为84%。然而，癌症治疗的后遗症，包括永久性器官和组织 损害、荷尔蒙和生殖功能障碍以及第二种癌症特别令人关注，有超过 在大约360,000名儿童癌症幸存者中，40%的人经历了与健康相关的重大疾病 儿童癌症的生活并发症及其治疗。此外，一些儿童癌症的进展 对于大约50%的急性髓系白血病儿童，50%的儿童 高危神经母细胞瘤和90%以上的脑干胶质瘤儿童仍然死于他们的疾病。 儿童肿瘤学小组(COG)，世界上最大的组织，专门致力于儿童和 青少年癌症研究及其由9000多名成员组成的多学科研究团队， 在220多家领先的儿童医院、大学和癌症中心进行研究。这项建议 是COG NCI社区肿瘤学研究计划(NCORP)研究基地继续其 为我们的26个社区和16个少数民族/未得到充分服务的NCORP站点开展合作研究工作。与COG的 重要的科学、统计、数据管理和信息技术基础设施，我们寻求进行 儿科临床试验，以确定最佳治疗方法，并进行实验室研究，将转化为更多 有效的治疗方法，减少副作用。COG直接处理NCORP的目标，即提供 在进行癌症控制研究的同时，在社区站点获得最先进的癌症治疗， 包括治疗后监测/生存，以及癌症护理的提供。我们促进以下组织的参与 在COG的所有研究、治理和管理以及NCORP网络中的社区调查人员 活动。COG的研究目标是减少总死亡率和发病率，减少急性和延迟 与治疗相关的毒性，并制定更有效的方式向儿童、青少年和 年轻人。COG NCORP研究基地处于独特的地位，可以阐明不同健康状况的影响 护理提供特征对结果的影响，以确定服务不足人群中预后较差的决定因素 包括青少年和青壮年，并制定有针对性的战略，以消除差距和 提高向癌症青年提供癌症护理的效率。

Project Summary The prognosis for children with cancer has improved dramatically over the past decades with an overall 5-year survival rate now at 84%. However, the late effects of cancer treatment, including permanent organ and tissue damage, hormonal and reproductive dysfunction and second cancers, are of special concern, with more than 40% of the estimated 360,000 survivors of childhood cancer experiencing a significant health-related quality of life complication from childhood cancer and its treatment. In addition, progress for a number of childhood cancers remains limited with approximately 50% of children with acute myelogenous leukemia, 50% of children with high-risk neuroblastoma, and more than 90% of children with brainstem glioma, still succumbing to their disease. The Children’s Oncology Group (COG), the world’s largest organization devoted exclusively to childhood and adolescent cancer research, and its multidisciplinary research teams comprised of more than 9,000 members, conducts research at more than 220 leading children’s hospitals, universities, and cancer centers. This proposal is for the COG NCI Community Oncology Research Program (NCORP) Research Base to continue its collaborative research work for our 26 community and 16 minority/underserved NCORP sites. With COG’s significant scientific, statistical, data management and information technology infrastructure, we seek to conduct pediatric clinical trials to define optimal treatments, and conduct laboratory research that will translate into more effective treatments with reduced side effects. The COG directly addresses the NCORP goals of providing access to state-of-the-art cancer treatment at community sites while conducting research in cancer control, including post-treatment surveillance/survivorship, and cancer care delivery. We promote the participation of community-based investigators in all of COG’s research, governance and administration and in NCORP Network activities. The COG’s research goals are to reduce overall mortality and morbidity, decrease acute and delayed treatment-related toxicities, and develop more effective ways of delivering care to children, adolescents and young adults. The COG NCORP Research Base is uniquely positioned to elucidate the impact of different health care delivery characteristics on outcomes, to identify determinants of poorer outcomes in underserved groups including adolescents and young adults, and to develop targeted strategies aimed at eliminating disparities and improving efficiencies for the delivery of cancer care in young persons with cancer.