COG NCORP Research Base

描述（由申请人提供）：儿童肿瘤小组（COG）是世界上最大的儿童癌症研究组织，包括224个儿科癌症项目，其使命是通过科学发现和富有同情心的护理来治愈和预防儿童和青少年癌症。GOG于2000年由四个传统儿科合作小组合并而成，COG社区临床肿瘤项目（CCOP）研究基地于2002年获得资助。拟议的COG NCORP研究基地将支持25个社区站点和12个少数民族/服务不足的社区站点，并且是唯一专门针对儿童和青少年的研究基地。它将涵盖美国社区儿科肿瘤学的几乎全部。COG NCORP研究基地将在社区站点提供最先进的癌症治疗，并在全国范围内促进癌症预防和控制、治疗后监测/生存和癌症护理方面的儿科研究。COG试验和实验室研究将转化为更有效的治疗方法，减少副作用。社区儿科肿瘤学家和其他卫生专业人员对COG的研究任务至关重要。NCORP站点提供了一种评估在社区环境中实施的先进治疗的方法。COG向NCORP站点提供当前的治疗方案，使其能够使用研究药物和专门的集中参考实验室，为NCORP人员提供持续培训和支持，质量保证基础设施，数据管理和统计支持，从而促进科学发现和为年轻人提供高质量的癌症治疗。COG的独特定位是阐明不同医疗保健提供系统和特征对癌症结果的影响，并确定某些种族/民族和服务不足群体（如青少年和年轻人）较差结果的决定因素。这种研究将通过消除差异和提高年轻人癌症治疗和后续护理的提供效率来改善结果。

DESCRIPTION (provided by applicant): The Children's Oncology Group (COG) is the largest childhood cancer research organization in the world encompassing 224 pediatric cancer programs with a mission to cure and prevent childhood and adolescent cancer through scientific discovery and compassionate care. GOG was formed from the merger of four legacy pediatric cooperative groups in 2000 and the COG Community Clinical Oncology Program (CCOP) Research Base was funded in 2002. The proposed COG NCORP Research Base will support 25 Community Sites and 12 Minority/Underserved Community Sites and is the only research base exclusively dedicated to children and adolescents. It will encompass the near totality of U.S. community pediatric oncology. The COG NCORP Research Base will provide access to state-of-the-art cancer treatment at community sites and nationally promote pediatric research in cancer prevention and control, post-treatment surveillance/survivorship, and cancer care delivery. COG trials and laboratory research will translate into more effective treatments with reduced side effects. Community-based pediatric oncologists and other health professionals are pivotal to COG's research mission. NCORP sites provide a means to evaluate advanced treatments administered in community settings. The COG makes available to NCORP sites current treatment protocols with access to investigational agents and special centralized reference laboratories, continuing training and support for NCORP personnel, quality assurance infrastructure, data management and statistical support, thus promoting scientific discovery and high quality cancer care for young persons. The COG is uniquely positioned to elucidate the impact of different health care delivery systems and characteristics on cancer outcomes and identify determinants of poorer outcomes in certain race/ethnic and underserved groups such as adolescents and young adults. Such research will improve outcomes by eliminating disparities and improving efficiencies for the delivery of cancer therapy and follow-up care in young persons.