Community Clinical Oncology Program

描述(申请人提供)：四家传统儿科医院合并 合作小组组建儿童？S肿瘤学小组(COG)介绍 为北美所有儿童提供服务的独特机会。我们的目标是 扩大癌症创新临床和转化性研究的渠道 治疗、预防和控制，提高参与水平 由CCOP/MBCCOP在COG的任务中。此应用程序支持COG 作为治疗和预防/控制社区临床肿瘤学计划 (CCOP)研究基地。COG将向CCOP/MBCCOP提供当前 可接触调查剂和特殊药物的治疗方案 集中参考实验室，从而促进高质量的癌症护理 适用于在社区环境中接受治疗的儿童。已经给予了高度优先考虑 关于开发可在较小COG中可行执行的协议 机构，其中包括我们的大多数附属CCOP。COG将鼓励 科委调查员全方面参与集团？S科学 使命除了招收患者参加研究外。中国奥组委将提供 对CCOP机构人员的持续培训和支持，包括 临床研究助理和肿瘤护士，并将确保所有 CCOP对会员、应计和 机构绩效。癌症控制委员会(CCC)负责管理 COG癌症防治研究计划。它的使命是改进 癌症儿童的护理和生存质量，以确保 为传统上服务不足的群体提供最先进的癌症治疗 (包括少数群体和青少年/青年人口)，并发展 儿童假说驱动的预防和控制研究。这个 CCC的成员是多样化的，包括以下临床学科 血液学/肿瘤学、外科、放射治疗、肿瘤学护理等 传染病的内科专家，儿科心脏病和 肺病学；公共卫生学科，包括流行病学、卫生服务 研究和生物统计学；以及心理学的行为研究人员， 社会学和社会工作。COG癌症控制研究包括评估 替代试验终点，如与健康相关的生活质量和经济 措施；确定和预防与治疗有关的后遗症； 症状管理、疼痛控制和支持性护理；以及社区肿瘤学 和外展。

DESCRIPTION (provided by applicant): The merger of the four legacy pediatric cooperative groups to form the Children?s Oncology Group (COG) presents a unique opportunity to serve all children in North America. Our goals are to expand access to innovative clinical and translational research for cancer treatment, prevention and control and to increase the level of participation by CCOPs/MBCCOPs in the mission of the COG. This application supports the COG as a treatment and prevention/control Community Clinical Oncology Program (CCOP) Research Base. The COG will make available to CCOPs/MBCCOPs current treatment protocols with access to investigational agents and special centralized reference laboratories, thus promoting high quality cancer care for children treated in community settings. A high priority has been placed on developing protocols that can be feasibly performed in smaller COG institutions, which include most of our affiliated CCOPs. COG will encourage CCOP investigators to participate in all aspects of the Group?s scientific mission in addition to enrolling patients on study. The COG will provide continuing training and support for CCOP institutional personnel including clinical research associates and oncology nurses, and will ensure that all CCOPs maintain high quality assurance standards for membership, accrual, and institutional performance. The Cancer Control Committee (CCC) administers the COG cancer prevention and control research program. Its mission is to improve the quality of care and survivorship for children with cancer, to ensure access to state-of-the-art cancer therapy for traditionally underserved groups (including minority and adolescent/young adult populations), and to develop hypothesis-driven prevention and control research for children. The membership of the CCC is diverse and includes the clinical disciplines of hematology/oncology, surgery, radiation therapy, oncology nursing, and other physician specialists for infectious diseases, pediatric cardiology and pulmonology; public health disciplines including epidemiology, health services research, and biostatistics; and behavioral researchers in psychology, sociology and social work. COG cancer control research includes assessment of alternate trial endpoints such as health-related quality-of-life and economic measures; the identification and prevention of treatment-related sequelae; symptom management, pain control and supportive care; and community oncology and outreach.