Children's Oncology Group NCI Community Oncology Research Program (NCORP) Research Base grant

项目摘要 在过去的几十年里，癌症儿童的预后有了显着改善，总体5年 存活率达到84%然而，癌症治疗的晚期效应，包括永久性器官和组织 损害，荷尔蒙和生殖功能障碍以及第二种癌症，特别令人关注， 在估计的360，000名儿童癌症幸存者中，有40%的人经历了与健康相关的重大问题， 儿童癌症的生活并发症及其治疗此外，一些儿童癌症的进展 仍然有限，大约50%的儿童急性髓细胞白血病，50%的儿童 高风险的神经母细胞瘤和超过90%的脑干神经胶质瘤儿童仍然死于他们的疾病。 儿童肿瘤学小组（COG）是世界上最大的专门致力于儿童和 青少年癌症研究，及其由9,000多名成员组成的多学科研究小组， 在220多家领先的儿童医院、大学和癌症中心开展研究。这项建议 是为COG NCI社区肿瘤学研究计划（NCORP）研究基地继续其 为我们的26个社区和16个少数民族/服务不足的NCORP网站的合作研究工作。关于COG 重要的科学，统计，数据管理和信息技术基础设施，我们力求进行 儿科临床试验，以确定最佳治疗，并进行实验室研究，将转化为更多 有效的治疗，减少副作用。COG直接解决NCORP的目标， 在进行癌症控制研究的同时，在社区获得最先进的癌症治疗， 包括治疗后监测/存活率和癌症护理提供。我们促进以下方面的参与： 在COG的所有研究，治理和管理以及NCORP网络中的社区调查员 活动COG的研究目标是降低总体死亡率和发病率， 治疗相关的毒性，并制定更有效的方式为儿童，青少年和 年轻人COG NCORP研究基地具有独特的优势，可以阐明不同健康 结果的护理提供特征，以确定服务不足群体结果较差的决定因素 包括青少年和年轻人在内的所有人，并制定有针对性的战略， 提高为年轻癌症患者提供癌症护理的效率。

Project Summary The prognosis for children with cancer has improved dramatically over the past decades with an overall 5-year survival rate now at 84%. However, the late effects of cancer treatment, including permanent organ and tissue damage, hormonal and reproductive dysfunction and second cancers, are of special concern, with more than 40% of the estimated 360,000 survivors of childhood cancer experiencing a significant health-related quality of life complication from childhood cancer and its treatment. In addition, progress for a number of childhood cancers remains limited with approximately 50% of children with acute myelogenous leukemia, 50% of children with high-risk neuroblastoma, and more than 90% of children with brainstem glioma, still succumbing to their disease. The Children’s Oncology Group (COG), the world’s largest organization devoted exclusively to childhood and adolescent cancer research, and its multidisciplinary research teams comprised of more than 9,000 members, conducts research at more than 220 leading children’s hospitals, universities, and cancer centers. This proposal is for the COG NCI Community Oncology Research Program (NCORP) Research Base to continue its collaborative research work for our 26 community and 16 minority/underserved NCORP sites. With COG’s significant scientific, statistical, data management and information technology infrastructure, we seek to conduct pediatric clinical trials to define optimal treatments, and conduct laboratory research that will translate into more effective treatments with reduced side effects. The COG directly addresses the NCORP goals of providing access to state-of-the-art cancer treatment at community sites while conducting research in cancer control, including post-treatment surveillance/survivorship, and cancer care delivery. We promote the participation of community-based investigators in all of COG’s research, governance and administration and in NCORP Network activities. The COG’s research goals are to reduce overall mortality and morbidity, decrease acute and delayed treatment-related toxicities, and develop more effective ways of delivering care to children, adolescents and young adults. The COG NCORP Research Base is uniquely positioned to elucidate the impact of different health care delivery characteristics on outcomes, to identify determinants of poorer outcomes in underserved groups including adolescents and young adults, and to develop targeted strategies aimed at eliminating disparities and improving efficiencies for the delivery of cancer care in young persons with cancer.