Effects of Alcohol and Tobacco Co-use on Momentary Subjective Cannabis Effects: Risks for Increasingly Hazardous Cannabis Use

项目总结 近年来，年轻人中与烟酒共用大麻的比率持续上升。 好几年了。大量研究表明，共同使用会使个人面临更大的驾驶风险 影响，较差的心理健康和认知，以及与之相关的物质使用障碍 单一物质的使用。尽管与大麻联合使用增加了流行率和风险 对于其他物质，这些联系背后的机制仍不清楚。它是被假设的 个人参与共同使用以获得更大的主观反应，而不是通过使用感受到的 每种物质都是单独的。鉴于先前的研究发现与以下方面相关的结果不一致和无效 共同使用的模式，这表明变化可能是复杂的，需要更仔细地审查- 人员流程。以前的研究也表明，对大麻的主观反应可能是 与大麻使用障碍(CUD)的发展相吻合；然而，从现有的文献中还不清楚 大麻的主观药物效应是否因与其他物质，如酒精和 烟草，随着时间的推移，增加危险使用的风险。拟议的研究将利用先进的统计方法 检查生态瞬时评估的方法论(例如，多层次建模、纵向分析) 以及来自NIDA R01项目的年轻成人娱乐用大麻使用者的纵向数据。目标1 该提案将研究大麻与酒精或烟草共同使用的场合(毒品、点餐、时机)如何影响 和目标2将审查这些主观反应是否 共同使用一年后预测危险的大麻使用。确定相关风险的潜在机制 与大麻共同使用将有助于开发更好的量身定制的干预方法，以减少公共卫生 青壮年儿童精神障碍的负担。

PROJECT SUMMARY The rates of cannabis co-use with alcohol and tobacco among young adults has continued to rise in recent years. Considerable research has shown that co-use places individuals at greater risk for driving under the influence, poorer mental-health and cognition, and co-morbid substance use disorders when compared to single-substance use. Despite the increased prevalence and risk associated with the co-use of cannabis with other substances, the mechanisms underlying these associations remains unclear. It has been hypothesized that individuals engage in co-use to achieve greater subjective responses beyond that perceived with the use of each substance alone. Given prior research has found inconsistent and null findings for outcomes related to patterns of co-use, this suggests changes may be complex and require more careful examination of within- person processes. Previous studies have also shown that subjective responses to cannabis may underlie or coincide the development of cannabis use disorder (CUD); however, it is unclear from the existing literature whether subjective drug effects of cannabis resulting from co-use with other substances, such as alcohol and tobacco, increases the risk for hazardous use over time. The proposed study will utilize advanced statistical methodology (e.g., multilevel modeling, longitudinal analyses) to examine ecological momentary assessment and longitudinal data in young adult recreational cannabis users from a NIDA R01 project. Aim 1 of the proposal will examine how cannabis co-use occasions with alcohol or tobacco (drug, ordering, timing) affects subjective drug abuse liability effects of cannabis; and Aim 2 will examine whether these subjective responses to co-use predict hazardous cannabis use one year later. Identifying underlying mechanisms of risk associated with cannabis co-use will help to develop better tailored intervention approaches to decrease the public health burden of CUDs among young adults.