Predictive markers for diabetic retinopathy via quantitative imaging of retinal capillary functions
通过视网膜毛细血管功能的定量成像预测糖尿病视网膜病变的标志物
基本信息
- 批准号:10461105
- 负责人:
- 金额:$ 46.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAcademyAddressAdultAffectAmericanAngiographyAttentionBackground Diabetic RetinopathyBenchmarkingBlindnessBloodBlood VesselsBlood capillariesBlood flowBlood-Retinal BarrierBostonCaringChronicClinicClinicalClinical ResearchCollaborationsDetectionDevelopmentDevicesDiabetic RetinopathyDiffuseDiseaseDisease ProgressionDyesExtravasationEyeEye diseasesFluoresceinFluorescein AngiographyFluorescenceFunctional disorderGoalsGoldHemoglobinHemorrhageHumanHyperglycemiaHypoxiaImageImaging DeviceImaging TechniquesIndividualInjectionsLasersLeadMeasurementMeasuresMedical centerMonitorMulti-modal optical imagingMultimodal ImagingNatural HistoryOphthalmologyOphthalmoscopyOptical Coherence TomographyOxygenPathogenicityPathologyPatientsPatternPerfusionPreventionPreventive treatmentProcessPrognostic MarkerPublic HealthResistanceResolutionRetinaRetinal DiseasesRetinal HemorrhageRiskScanningSeveritiesSpeedStatistical Data InterpretationSystemTechniquesTestingThree-Dimensional ImagingTimeTreatment FactorTreatment outcomeUnited StatesVascular Endothelial Growth FactorsVisible RadiationVisionaging populationbaseclinical examinationdiabeticdiabetic patientdiagnosis standardeye centerfluorescence imagingfollow-upimaging biomarkerimaging capabilitiesimaging modalityin vivoinsightmacular edemamultimodalityneovascularizationnovelnovel imaging techniqueoptical imagingpredicting responsepredictive markerpreventprognostic valueproliferative diabetic retinopathyquantitative imagingrecruitresponseretinal imagingstandard of caresuccesstargeted imagingtreatment responsetreatment strategy
项目摘要
PROJECT SUMMARY
Diabetic retinopathy (DR) remains the leading cause of blindness, affecting over 4 million Americans. The
prediction of DR progression and treatment outcome holds the key in the care for DR and the prevention of
vision-threating conditions. However, clinicians are now faced with the challenge of limited established
predictors for the development of DR and treatment response. Our hypothesis is that capillary dysfunction, as
the central crux of the DR pathology, is a sensitive predictor of DR progression and treatment outcome. In
diabetic eyes, hyperglycemia leads to capillary dysfunction which leads to a breakdown of the blood retinal
barrier (BRB) resulting in capillary leakage. This capillary dysfunction further leads to capillary loss and non-
perfusion, which causes ischemic hypoxia. The combined effects of capillary leakage and hypoxia results in
neovascularization and retinal hemorrhage, signifying the onset of proliferative DR. In this pathogenic process,
capillary leakage, oxygenation, and capillary blood flow are three key aspects of capillary function, and
therefore have become our targets of imaging and quantification. We have developed visible light optical
coherence tomography (OCTA) to non-invasively quantify blood oxygenation at the capillary level. We have
also shown that measuring the dynamics of near infrared OCTA allows quantification of the flow dynamics of
capillary flow. The quantification of both oxygenation and flow dynamics provides measurement of capillary
perfusions. In addition, we have developed a novel multimodal 3D imaging technique, oblique scanning laser
ophthalmology (oSLO), which unprecedentedly enables wide-field 3D fluorescence imaging in the retina. Since
the administration of fluorescein dye is a component of the standard of care and fluorescein angiography (FA)
is the gold standard for diagnosing DR, the 3D imaging capability of oSLO can uniquely provide sensitive
detection of dye leakage. Taken altogether, we will explore three specific aims. 1) To develop a multimodal
oSLO/OCT system to quantify capillary blood oxygenation, flow dynamics, and leakage, with large field of view,
high resolution and high speed. 2) To conduct a pilot clinical study to assess the correlation of DR severity to
retinal capillary function in humans. 3) To explore the prognostic value of imaging markers for capillary
functions that can predict anti-VEGF treatment response. IMPACT ON PUBLIC HEALTH: 1) The success of
this project will lead to a groundbreaking new imaging device that is currently not available. 2) The validity of
the imaging method could also lead to further clinical studies on predictive imaging markers on DR progression
and treatment response. 3) The multiple measurements of capillary functions will provide further insight into the
pathophysiology and new treatment strategies for this debilitating eye disease.
项目摘要
糖尿病视网膜病变(DR)仍然是失明的主要原因,影响超过400万美国人。的
DR进展和治疗结果的预测是DR护理和预防的关键。
视觉威胁的条件。然而,临床医生现在面临着有限的挑战,
预测DR的发展和治疗反应。我们的假设是毛细血管功能障碍,
DR病理学的中心症结,是DR进展和治疗结果的敏感预测因子。在
糖尿病患者的眼睛,高血糖导致毛细血管功能障碍,这导致血液视网膜的破坏
屏障(BRB)导致毛细血管渗漏。这种毛细血管功能障碍进一步导致毛细血管损失和非-
导致缺血性缺氧。毛细血管渗漏和缺氧的综合作用导致
新生血管形成和视网膜出血,标志着增殖性DR的发生。在这个致病过程中,
毛细血管渗漏、氧合和毛细血管血流是毛细血管功能的三个关键方面,
因此成为我们成像和量化的目标。我们开发了可见光光学
相干断层扫描(OCTA),以非侵入性地量化在毛细血管水平的血氧。我们有
还表明,测量近红外OCTA的动态允许量化的流动动力学,
毛细流动氧合和流动动力学两者的量化提供了毛细血管的测量。
灌注。此外,我们还开发了一种新的多模态3D成像技术,斜扫描激光
眼科学(奥斯陆),其前所未有地实现了视网膜中的宽视场3D荧光成像。以来
给予荧光素染料是标准护理和荧光素血管造影(FA)的一部分
是诊断DR的金标准,奥斯陆的3D成像能力可以独特地提供敏感的
检测染料泄漏。总的来说,我们将探讨三个具体目标。1)发展多式联运
奥斯陆/OCT系统,用于量化毛细血管血氧合、血流动力学和渗漏,具有大视野,
高分辨率和高速度。2)进行初步临床研究,以评估DR严重程度与
人类视网膜毛细血管功能。3)探讨影像学标记物对毛细血管病变的预后价值
可以预测抗VEGF治疗反应的功能。对公众健康的影响:1)
这个项目将导致一个突破性的新的成像设备,目前还没有。2)的有效性
该成像方法还可以导致对DR进展的预测性成像标记物的进一步临床研究
和治疗反应。3)对毛细血管功能的多次测量将提供对毛细血管功能的进一步了解。
病理生理学和新的治疗策略,这种衰弱性眼病。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Non-interferometric volumetric imaging in living human retina by confocal oblique scanning laser ophthalmoscopy.
通过共焦倾斜扫描激光检眼镜对活人视网膜进行非干涉体积成像。
- DOI:10.1364/boe.457408
- 发表时间:2022
- 期刊:
- 影响因子:3.4
- 作者:Shao,Wenjun;Yi,Ji
- 通讯作者:Yi,Ji
Special Section Guest Editorial: Advances in Retinal Imaging.
特别版块客座社论:视网膜成像的进展。
- DOI:10.1117/1.nph.6.4.041101
- 发表时间:2019
- 期刊:
- 影响因子:5.3
- 作者:Yi,Ji;Dubra,Alfredo;Farsiu,Sina
- 通讯作者:Farsiu,Sina
Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification
- DOI:10.1038/s41377-019-0216-0
- 发表时间:2019-11-20
- 期刊:
- 影响因子:19.4
- 作者:Liu, Rongrong;Cheng, Shiyi;Yi, Ji
- 通讯作者:Yi, Ji
Is oblique scanning laser ophthalmoscope applicable to human ocular optics? A feasibility study using an eye model for volumetric imaging.
斜扫描激光检眼镜适用于人眼光学吗?
- DOI:10.1002/jbio.201960174
- 发表时间:2020
- 期刊:
- 影响因子:2.8
- 作者:Shao,Wenjun;Song,Weiye;Yi,Ji
- 通讯作者:Yi,Ji
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ji Yi其他文献
Ji Yi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ji Yi', 18)}}的其他基金
Advancing visible light optical coherence tomography in glaucoma detection
推进可见光光学相干断层扫描在青光眼检测中的应用
- 批准号:
10567788 - 财政年份:2023
- 资助金额:
$ 46.93万 - 项目类别:
Mesoscopic microscopy for ultra-high speed and large-scale volumetric brain imaging
用于超高速和大规模脑体积成像的介观显微镜
- 批准号:
10634911 - 财政年份:2023
- 资助金额:
$ 46.93万 - 项目类别:
A novel method for volumetric oxygen mapping in living retina
一种在活体视网膜中进行体积氧测绘的新方法
- 批准号:
10597011 - 财政年份:2021
- 资助金额:
$ 46.93万 - 项目类别:
A novel method for volumetric oxygen mapping in living retina
一种在活体视网膜中进行体积氧测绘的新方法
- 批准号:
10361407 - 财政年份:2021
- 资助金额:
$ 46.93万 - 项目类别:
Sensitive detection of malignancy in primary acquired melanosis by advanced optical imaging
通过先进光学成像灵敏检测原发性获得性黑变病的恶性肿瘤
- 批准号:
10251585 - 财政年份:2020
- 资助金额:
$ 46.93万 - 项目类别:
Predictive markers for diabetic retinopathy via quantitative imaging of retinal capillary functions
通过视网膜毛细血管功能的定量成像预测糖尿病视网膜病变的标志物
- 批准号:
10220441 - 财政年份:2018
- 资助金额:
$ 46.93万 - 项目类别:
Predictive markers for diabetic retinopathy via quantitative imaging of retinal capillary functions
通过视网膜毛细血管功能的定量成像预测糖尿病视网膜病变的标志物
- 批准号:
10250563 - 财政年份:2018
- 资助金额:
$ 46.93万 - 项目类别:
相似海外基金
REU Site: Summer Academy in Sustainable Manufacturing
REU 网站:可持续制造夏季学院
- 批准号:
2348993 - 财政年份:2024
- 资助金额:
$ 46.93万 - 项目类别:
Standard Grant
The European Hydrogen Academy (HyAcademy.EU)
欧洲氢学院 (HyAcademy.EU)
- 批准号:
10110448 - 财政年份:2024
- 资助金额:
$ 46.93万 - 项目类别:
EU-Funded
GP-UP Ocean Research College Academy Engagement in Authentic Geoscience Learning Ecosystems (ORCA-EAGLE)
GP-UP 海洋研究学院学院参与真实的地球科学学习生态系统 (ORCA-EAGLE)
- 批准号:
2326962 - 财政年份:2024
- 资助金额:
$ 46.93万 - 项目类别:
Standard Grant
HyAcademy.EU: The European Hydrogen Academy
HyAcademy.EU:欧洲氢学院
- 批准号:
10101978 - 财政年份:2024
- 资助金额:
$ 46.93万 - 项目类别:
EU-Funded
Baycrest Academy for Research and Education Summer Program in Aging (SPA): Strengthening research competencies, cultivating empathy, building interprofessional networks and skills, and fostering innovation among the next generation of healthcare workers t
Baycrest Academy for Research and Education Summer Program in Aging (SPA):加强研究能力,培养同理心,建立跨专业网络和技能,并促进下一代医疗保健工作者的创新
- 批准号:
498310 - 财政年份:2024
- 资助金额:
$ 46.93万 - 项目类别:
Operating Grants
Conference: Cyberinfrastructure Leadership Academy: Team Science and Grand Challenges
会议:网络基础设施领导学院:团队科学和重大挑战
- 批准号:
2414440 - 财政年份:2024
- 资助金额:
$ 46.93万 - 项目类别:
Standard Grant
Travel: NSF Student Travel Grant for 2024 Academy of Management Annual Meeting (AOM)
旅行:2024 年管理学院年会 (AOM) 的 NSF 学生旅行补助金
- 批准号:
2420866 - 财政年份:2024
- 资助金额:
$ 46.93万 - 项目类别:
Standard Grant
Semiconductor Higher Technical Skills Academy Wales: Recruitment, Retention & Upskilling
威尔士半导体高等技术技能学院:招聘、保留
- 批准号:
10076049 - 财政年份:2023
- 资助金额:
$ 46.93万 - 项目类别:
Collaborative R&D
Simulation Academy at Yale: Youth Entering Science (SAY-YES!)
耶鲁大学模拟学院:青年进入科学(说是!)
- 批准号:
10663646 - 财政年份:2023
- 资助金额:
$ 46.93万 - 项目类别:
Collaborative Research: GP-GO: Climate Leaders Academy: a professional development opportunity in the geosciences
合作研究:GP-GO:气候领袖学院:地球科学领域的专业发展机会
- 批准号:
2232215 - 财政年份:2023
- 资助金额:
$ 46.93万 - 项目类别:
Continuing Grant