The Massachusetts General Hospital Harvard Center for Reproductive Medicine

马萨诸塞州总医院哈佛生殖医学中心

基本信息

  • 批准号:
    10463543
  • 负责人:
  • 金额:
    $ 155.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-10 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT ABSTRACT Infertility affects up to 13% of reproductive age couples across the globe but the underlying mechanistic basis of infertility and the role of infertility as an overall marker of general health is unclear. These knowledge gaps hinder the diagnosis, treatment and prevention of infertility leading to physical, psychological and financial burden to couples with infertility. To address these challenges, The Massachusetts General Hospital Harvard Center for Reproductive Medicine has assembled an integrative team of investigators with expertise in reproductive medicine, genomics, population genetics and genetic literacy who will conduct clinical translational investigation in humans with infertility: Aim 1: To elucidate the genetic and phenomic architecture of infertility through the lens of specific rare diseases and common traits; Aim 2: To catalyze a collaborative think-tank focused on reducing the suffering and costs of infertility, in a manner that is outward looking, forward thinking and integrates global perspectives; Aim 3: To nucleate a vibrant hub for outreach, training and community engagement that brings the scientific team closer to the patients they serve, the trainees they want to mentor, and the larger community of scientists and clinicians who are invested in reducing the burdens caused by infertility. These aims will be achieved using two Clinical Research projects which will be supported by a Genomics and Functional Core, Outreach Core and Administrative Core. Project 1 will perform next-generation sequencing and targeted genotype-driven phenotyping studies in clinical cohorts enriched for genetically driven infertility from admixed and consanguineous populations characterized by both hypogonadotropic and hypergonadotropic hypogonadism in both sexes. Project 2 will bring together >1,800,000 multi-ethnic population biobank samples to perform genome-wide association studies, phenome-wide association studies, and Mendelian randomization studies to implicate key biologic pathways determining fertility and synthesize the genetic results across infertility and related traits to characterize the effects of the identified genes and pathways on reproductive health and overall morbidity. The Genomics and Functional Core will provide genomic technologies, data analytics, computational and statistical support, and will generate genetically engineered human induced pluripotent cells for validation of Project 1 & 2 genetic discoveries. The Outreach Core will buoy Project 1 & 2 activities by engaging key stakeholders through patient group meetings, creating clinician-facing materials to enable communication of genetic results and launch a website inspired by design-thinking for broad dissemination to patients, families and clinicians. The Administrative Core will advance the Center’s scientific goals by providing timely support to foster engagement and communication between investigators, patients, research trainees and the broader academic community. Through these interdigitating activities, the Center will train the next generation of reproductive biologists and the results emanating from its activities will help inform clinical care and alleviate the suffering of patients with infertility.
项目摘要 不孕症影响了地球仪上多达13%的育龄夫妇,但不孕症的潜在机制基础是, 不孕症和不孕症作为一般健康的总体标志的作用尚不清楚。这些知识差距阻碍了 诊断、治疗和预防不孕导致的身体、心理和经济负担, 不孕不育的夫妇为了应对这些挑战,马萨诸塞州总医院哈佛中心 生殖医学已经组建了一个由具有生殖医学专业知识的研究人员组成的综合团队。 医学,基因组学,群体遗传学和遗传素养,他们将进行临床转化研究 目的1:通过透镜阐明不孕症的遗传和表型结构 目标2:促进建立一个合作智囊团,重点是减少 不孕症的痛苦和代价,以一种外向的方式,前瞻性的思维和整合全球 目标3:成为一个充满活力的外联、培训和社区参与中心, 科学团队更接近他们所服务的患者,他们想要指导的学员,以及更大的社区, 科学家和临床医生致力于减轻不孕症造成的负担。这些目标将是 通过两个临床研究项目实现,该项目将得到基因组学和功能核心的支持, 外展核心和行政核心。项目1将进行下一代测序, 在临床队列中进行的基因型驱动的表型研究, 和具有低促性腺激素和高促性腺激素特征的近亲群体 两性性腺功能减退症。项目2将汇集超过180万个多族裔人口生物库样本 进行全基因组关联研究、全表型关联研究和孟德尔随机化 研究涉及决定生育力的关键生物途径,并综合不孕症的遗传结果 和相关性状,以表征所确定的基因和途径对生殖健康的影响, 总体发病率。基因组学和功能核心将提供基因组技术、数据分析, 计算和统计支持,并将产生基因工程人类诱导多能细胞 用于验证项目1和2的基因发现。外联核心将通过以下方式支持项目1和2的活动: 通过患者小组会议吸引关键利益相关者,创建面向临床医生的材料, 交流遗传结果,并推出一个受设计思维启发的网站,以广泛传播, 患者、家属和临床医生。行政核心将通过提供以下服务来推进中心的科学目标: 及时提供支持,以促进研究者、患者、研究学员之间的参与和沟通, 更广泛的学术界。通过这些相互交织的活动,该中心将培训下一个 生殖生物学家的产生及其活动产生的结果将有助于告知临床护理 减轻不孕症患者的痛苦。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Stephanie Beth Seminara其他文献

Stephanie Beth Seminara的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Stephanie Beth Seminara', 18)}}的其他基金

Phase 2 Kp-10 in Patients with Hypogonadotropic Hypogonadism
低促性腺激素性性腺功能减退症患者的 2 期 Kp-10
  • 批准号:
    10730209
  • 财政年份:
    2023
  • 资助金额:
    $ 155.04万
  • 项目类别:
Project 1 - Deciphering the Molecular Drivers of Rare Forms of Human Infertility Using Integrative Genomic, Cellular, and Phenomic Approaches
项目 1 - 使用综合基因组、细胞和表型组方法破译罕见人类不孕症的分子驱动因素
  • 批准号:
    10463545
  • 财政年份:
    2021
  • 资助金额:
    $ 155.04万
  • 项目类别:
The Massachusetts General Hospital Harvard Center for Reproductive Medicine
马萨诸塞州总医院哈佛生殖医学中心
  • 批准号:
    10613357
  • 财政年份:
    2021
  • 资助金额:
    $ 155.04万
  • 项目类别:
Core A - Administrative
核心 A - 行政
  • 批准号:
    10463544
  • 财政年份:
    2021
  • 资助金额:
    $ 155.04万
  • 项目类别:
Core A - Administrative
核心 A - 行政
  • 批准号:
    10613358
  • 财政年份:
    2021
  • 资助金额:
    $ 155.04万
  • 项目类别:
Project 1 - Deciphering the Molecular Drivers of Rare Forms of Human Infertility Using Integrative Genomic, Cellular, and Phenomic Approaches
项目 1 - 使用综合基因组、细胞和表型组方法破译罕见人类不孕症的分子驱动因素
  • 批准号:
    10613359
  • 财政年份:
    2021
  • 资助金额:
    $ 155.04万
  • 项目类别:
Phase 2 Kp-10 for Dopamine Agonist Intolerant Hyperprolactinemia IND 74,977
多巴胺激动剂不耐受高催乳素血症 2 期 Kp-10 IND 74,977
  • 批准号:
    10116170
  • 财政年份:
    2018
  • 资助金额:
    $ 155.04万
  • 项目类别:
Kisspeptin and Neurokinin B: Physiology in Monkey to Pathophysiology in Human
Kisspeptin 和 Neurokinin B:从猴子的生理学到人类的病理生理学
  • 批准号:
    9431349
  • 财政年份:
    2017
  • 资助金额:
    $ 155.04万
  • 项目类别:
Kisspeptin Physiology in Human Reproduction
Kisspeptin 人类生殖生理学
  • 批准号:
    8190179
  • 财政年份:
    2011
  • 资助金额:
    $ 155.04万
  • 项目类别:
Kisspeptin Physiology in Human Reproduction
Kisspeptin 人类生殖生理学
  • 批准号:
    8334058
  • 财政年份:
    2011
  • 资助金额:
    $ 155.04万
  • 项目类别:

相似海外基金

Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
  • 批准号:
    495182
  • 财政年份:
    2023
  • 资助金额:
    $ 155.04万
  • 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
  • 批准号:
    2601817
  • 财政年份:
    2021
  • 资助金额:
    $ 155.04万
  • 项目类别:
    Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
  • 批准号:
    2029039
  • 财政年份:
    2020
  • 资助金额:
    $ 155.04万
  • 项目类别:
    Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
  • 批准号:
    9888417
  • 财政年份:
    2019
  • 资助金额:
    $ 155.04万
  • 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
  • 批准号:
    17K11318
  • 财政年份:
    2017
  • 资助金额:
    $ 155.04万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9320090
  • 财政年份:
    2017
  • 资助金额:
    $ 155.04万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    10166936
  • 财政年份:
    2017
  • 资助金额:
    $ 155.04万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9761593
  • 财政年份:
    2017
  • 资助金额:
    $ 155.04万
  • 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
  • 批准号:
    BB/M50306X/1
  • 财政年份:
    2014
  • 资助金额:
    $ 155.04万
  • 项目类别:
    Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
  • 批准号:
    288272
  • 财政年份:
    2013
  • 资助金额:
    $ 155.04万
  • 项目类别:
    Miscellaneous Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了