Phase 2 Kp-10 in Patients with Hypogonadotropic Hypogonadism

低促性腺激素性性腺功能减退症患者的 2 期 Kp-10

• 批准号: 10730209
• 负责人: Stephanie Beth Seminara
• 金额: $ 65万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730209
• 关键词: Phase; Kp; 10; Patients; Hypogonadotropic

PROJECT ABSTRACT Patients with idiopathic hypogonadotropic hypogonadism (IHH) have insufficient GnRH secretion. The lack of endogenous GnRH leads to absent LH and FSH, resulting in suppression of ovarian and testicular function and decreased levels of estradiol and testosterone. The neuropeptide kisspeptin is a powerful stimulus for GnRH induced LH secretion. The goal of this study is to explore the effects of pulsatile kisspeptin to stimulate the hypothalamic GnRH neurons of patients with HH. Thus, this application, if funded, can facilitate the translation of this therapeutic potential to the clinic.

项目摘要 特发性低促性腺激素性腺功能减退症（IHH）患者GnRH分泌不足。缺乏 内源性GnRH导致LH和FSH缺失，导致卵巢和睾丸功能抑制， 雌二醇和睾酮水平下降神经肽kisspeptin是促性腺激素释放激素的强有力刺激物 诱导LH分泌。本研究的目的是探讨脉冲kisspeptin刺激的影响， HH患者下丘脑GnRH神经元。因此，这个应用程序，如果资助，可以促进翻译 临床上的治疗潜力。