Core A: Administrative Core

核心A -总结 行政核心（核心A）将监督和协调内部的所有行政和研究活动。 这个戒酒会这所有项目负责人都在格莱斯顿神经病学研究所担任主要教职。 疾病（GIND），Mucke博士自1998年成立以来一直指导该项目。他对这个研究所的领导， 联合任命在神经病学系和各种研究生培训计划在加州大学旧金山分校，并长期 他在有关国家和国际咨询委员会的服务记录使他处于一个极好的位置， 领导这个核心。他与黄亚东博士（项目1）和Jorge Palop（项目2）合作， 阿尔茨海默病（AD）研究大约二十年，正如许多被广泛引用的，合著的 出版物在这一领域，最近招募博士瑞安科塞斯（项目3和核心B）格莱斯顿和加州大学旧金山分校。 多年来，他还通过Katie Pollard博士和Alex皮科博士（核心B）密切互动 格莱斯顿生物信息学核心的领导角色项目与核心之间建立良好的关系 领导者将极大地帮助核心A完成其监督、协调和支持研究的总体目标 在所有项目和核心中提出。该计划项目将直接关注AD并非常重视 项目之间的凝聚力和协作互动。核心A将严格支持和执行这些 功能和帮助确保我们的计划不仅解决真正重要的生物医学问题，而且 为科学发展和AD相关研究的进步创造了各种机会， 成员，从研究生和博士后研究员到初级和高级教师。具体而言，核心 A将制定和实施全项目范围的程序，以确保最佳水平的科学严谨性、数据安全， 所有四个项目和科学核心的成本效益和问责制;鼓励和促进 所有项目和核心领导者之间以及项目成员和其他 与Gladstone，UCSF及其他相关利益相关的团体;调查相关资源和研究领域 并提醒项目和核心领导人注意概念或技术的发展，这些发展可能会促进追求 他们的具体目标;成立一个外部咨询委员会，并安排定期会议，以审查该计划 并向所有项目和核心领导人提供建设性反馈;准备进度报告;协调 在计划成员中出版;与核心B合作，确保有效传播 项目产生的数据、试剂和研究成果将被广泛地传播给科学界。

CORE A – SUMMARY The Administrative Core (Core A) will oversee and coordinate all administrative and research activities within this program. All project leaders have primary faculty appointments in the Gladstone Institute of Neurological Disease (GIND), which Dr. Mucke has directed since its inauguration in 1998. His leadership of this institute, joint appointments in the Department of Neurology and various graduate training programs at UCSF, and long record of service on relevant national and international advisory committees put him in an excellent position to lead this core. He has collaborated with Drs. Yadong Huang (Project 1) and Jorge Palop (Project 2) on Alzheimer’s disease (AD) research for roughly two decades, as highlighted by many widely cited, coauthored publications in this field, and recently recruited Dr. Ryan Corces (Project 3 and Core B) to Gladstone and UCSF. For many years, he has also interacted closely with Drs. Katie Pollard and Alex Pico (Core B) through their leadership roles in Gladstone’s Bioinformatics Core. The well-established relationships among project and core leaders will greatly help Core A to accomplish its overall goal of overseeing, coordinating, and supporting studies proposed in all projects and cores. This program project will focus squarely on AD and places great emphasis on cohesiveness and collaborative interactions among projects. Core A will critically support and enforce these features and help ensure that our program not only addresses truly important biomedical problems, but also creates diverse opportunities for scientific growth and advancement in AD-relevant research for all of its members, ranging from graduate students and postdoctoral fellows to junior and senior faculty. Specifically, Core A will develop and implement program-wide procedures to ensure optimal levels of scientific rigor, data safety, cost effectiveness, and accountability across all four projects and the scientific core; encourage and facilitate collaborative interactions among all project and core leaders as well as between program members and other groups with related interests at Gladstone, UCSF, and beyond; survey relevant resources and fields of research and alert project and core leaders to conceptual or technological developments that could enhance the pursuit of their specific aims; form an external advisory committee and arrange regular meetings to review the program and provide constructive feedback to all project and core leaders; prepare progress reports; coordinate publications among program members; and collaborate with Core B to ensure the efficient dissemination of program-generated data, reagents, and research findings to the broader scientific community.