Core A: Administrative Core

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CORE A – SUMMARY The Administrative Core (Core A) will oversee and coordinate all administrative and research activities within this program. All project leaders have primary faculty appointments in the Gladstone Institute of Neurological Disease (GIND), which Dr. Mucke has directed since its inauguration in 1998. His leadership of this institute, joint appointments in the Department of Neurology and various graduate training programs at UCSF, and long record of service on relevant national and international advisory committees put him in an excellent position to lead this core. He has collaborated with Drs. Yadong Huang (Project 1) and Jorge Palop (Project 2) on Alzheimer’s disease (AD) research for roughly two decades, as highlighted by many widely cited, coauthored publications in this field, and recently recruited Dr. Ryan Corces (Project 3 and Core B) to Gladstone and UCSF. For many years, he has also interacted closely with Drs. Katie Pollard and Alex Pico (Core B) through their leadership roles in Gladstone’s Bioinformatics Core. The well-established relationships among project and core leaders will greatly help Core A to accomplish its overall goal of overseeing, coordinating, and supporting studies proposed in all projects and cores. This program project will focus squarely on AD and places great emphasis on cohesiveness and collaborative interactions among projects. Core A will critically support and enforce these features and help ensure that our program not only addresses truly important biomedical problems, but also creates diverse opportunities for scientific growth and advancement in AD-relevant research for all of its members, ranging from graduate students and postdoctoral fellows to junior and senior faculty. Specifically, Core A will develop and implement program-wide procedures to ensure optimal levels of scientific rigor, data safety, cost effectiveness, and accountability across all four projects and the scientific core; encourage and facilitate collaborative interactions among all project and core leaders as well as between program members and other groups with related interests at Gladstone, UCSF, and beyond; survey relevant resources and fields of research and alert project and core leaders to conceptual or technological developments that could enhance the pursuit of their specific aims; form an external advisory committee and arrange regular meetings to review the program and provide constructive feedback to all project and core leaders; prepare progress reports; coordinate publications among program members; and collaborate with Core B to ensure the efficient dissemination of program-generated data, reagents, and research findings to the broader scientific community.