Novel antimicrobials targeting MDR pathogens from animal microbial symbionts

针对动物微生物共生体中的耐多药病原体的新型抗菌药物

• 批准号: 10592380
• 负责人: David R Andes
• 金额: $ 595.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592380
• 关键词: Address; Anabolism; Animals; Anti-Infective Agents; Antibiotics; Antimicrobial Resistance; Bacteria; Biological; Biological Assay; Chemicals; Computational Biology; Culture Techniques; Development; Drug resistance; Ecology; Environment; Epidemic; Genomics; Goals; Health; Human; In Vitro; Invertebrates; Investigation; Lead; Libraries; Medicine; Methods; Microbe; Microbial Genome Sequencing; Mining; Minority; Natural Compound; Natural Products; Natural Products Chemistry; Pathogenesis; Pathway interactions; Pharmaceutical Preparations; Production; Property; Public Health; Research; Resistance; Resources; Safety; Series; Soil; Source; Streptomyces; Symbiosis; Taxon; Techniques; Technology; Testing; Therapeutic; Wisconsin; Work; antimicrobial; antimicrobial drug; antimicrobial resistant infection; clinical development; combat; drug development; drug discovery; drug resistant bacteria; drug resistant pathogen; effective therapy; fungus; in vivo; industry partner; innovation; insight; marine; metabolomics; microbial; microbiome; multi-drug resistant pathogen; multidisciplinary; natural antimicrobial; next generation; novel; novel therapeutics; pathogen; pathogenic bacteria; pathogenic fungus; pre-clinical; preclinical study; scaffold; secondary metabolite; small molecule; success; symbiont; theories

Project Summary The discovery of new antimicrobials has failed to keep pace with the emergence of antimicrobial-resistant infections, threatening public health. The overarching goal of the Wisconsin Antimicrobial Drug Discovery and Development Center is to develop therapeutic countermeasures to tackle the antimicrobial resistance crisis. Based upon our preliminary investigations using interdisciplinary, cutting-edge approaches, we hypothesize that natural products from animal-microbe symbioses represent a new paradigm in antimicrobial drug discovery. The Center proposes innovative conceptual and technical advances to overcome the critical bottlenecks of traditional antimicrobial discovery to deliver therapeutic countermeasures for the drug-resistance epidemic. Relevance There is an ever-present and growing need to find novel, effective therapies for emerging resistant pathogens that are becoming an increasing threat to the public health. The goals of the Center are to discover new antimicrobial drugs. Our collaborative effort focuses on high-value natural products produced by under- explored sources of biological and chemical diversity.

项目总结