Novel antimicrobials targeting MDR pathogens from animal microbial symbionts

项目摘要 新抗菌剂的发现未能跟上抗菌素耐药性的出现 感染，威胁公共健康。威斯康星州抗菌药物发现和 发展中心正在制定治疗对策，以应对抗菌素耐药性危机。 根据我们使用跨学科、尖端方法进行的初步调查，我们假设 来自动物-微生物共生的天然产物代表了抗微生物药物发现的新范式。这个 中心提出了创新的概念和技术进步，以克服传统 抗菌素的发现，为抗药性流行提供治疗对策。 相关性 对于新出现的耐药病原体，寻找新的、有效的治疗方法的需求一直存在且日益增长。 对公众健康构成越来越大的威胁。该中心的目标是发现新的 抗菌药物。我们的合作重点是由Under生产的高价值天然产品 探索生物和化学多样性的来源。

Project Summary The discovery of new antimicrobials has failed to keep pace with the emergence of antimicrobial-resistant infections, threatening public health. The overarching goal of the Wisconsin Antimicrobial Drug Discovery and Development Center is to develop therapeutic countermeasures to tackle the antimicrobial resistance crisis. Based upon our preliminary investigations using interdisciplinary, cutting-edge approaches, we hypothesize that natural products from animal-microbe symbioses represent a new paradigm in antimicrobial drug discovery. The Center proposes innovative conceptual and technical advances to overcome the critical bottlenecks of traditional antimicrobial discovery to deliver therapeutic countermeasures for the drug-resistance epidemic. Relevance There is an ever-present and growing need to find novel, effective therapies for emerging resistant pathogens that are becoming an increasing threat to the public health. The goals of the Center are to discover new antimicrobial drugs. Our collaborative effort focuses on high-value natural products produced by under- explored sources of biological and chemical diversity.