Admin Core

项目摘要 抗菌素创新已经放缓到爬行，而抗菌素耐药性感染的流行激增， 威胁公众健康。威斯康星州抗菌药物发现和 发展中心正在制定治疗对策，以应对抗菌素耐药性危机。 根据我们的初步数据，我们假设自然界对共生环境的探索 使用互补的尖端方法将为发现小说提供一个新的范式 针对耐药感染的抗菌药。该中心提出了创新的概念和技术 克服传统抗微生物药物发现平台中确定的关键瓶颈的进展。这个 这项工作的成功取决于不同的科学家和技术人员的共同努力 资源。行政核心将由安第斯山脉指导，并由内部和外部咨询提供咨询 由传染病、抗菌素耐药性、药物发现和开发方面的专家组成的委员会， 天然产品、技术转让和许可。此外，它还将包括一名具有 在研究和商业管理方面有丰富的经验，并优先监督NIH资助的项目 项目和中心。行政核心的总体目标是提供领导力和 这项建议的组织骨干，促进项目和核心之间的协作，以及 协调其与NIAID工作人员的互动。 /相关性/ 对于正在成为日益严重的威胁的新出现的耐药病原体，目前还没有有效的治疗方法 对公众健康的影响。该中心的目标是通过以下途径提供新的广谱抗菌剂 合作的重点是开发不足的生物来源产生的高价值天然产品铅 多样性。

Project Summary Antimicrobial innovation has slowed to a crawl while an epidemic of antimicrobial-resistant infections surges, threatening the public health. The overarching goal of the Wisconsin Antimicrobial Drug Discovery and Development Center is to develop therapeutic countermeasures to tackle the antimicrobial resistance crisis. Based upon our preliminary data, we hypothesize that natural product exploration of symbiotic environments using complementary cutting-edge approaches will provide a new paradigm for discovery of novel antimicrobials targeting drug resistant infections. The Center proposes innovative conceptual and technical advances to overcome critical bottlenecks identified in traditional antimicrobial drug discovery platforms. The success of this endeavor hinges upon the cohesive efforts from a diverse group of scientists and technical resources. The Administrative Core will be directed by Andes and advised by an Internal and External Advisory Board comprised of experts in infectious diseases, antimicrobial resistance, drug discovery and development, natural products, and technology transfer and licensing. Additionally, it will include an administrator with extensive experience in research and business administration, and prior oversight of NIH funded program projects and centers. The overall goals of the administrative core are to provide leadership and the organizational back bone for this proposal, promote collaboration between the Projects and Cores, and coordinate its interaction with NIAID staff. /Relevance/ There are no effective therapies for the emerging resistant pathogens that are becoming an increasing threat to the public health. The goals of the Center are to provide new, broad spectrum antimicrobial agents through a collaborative focus on high value natural product leads produced by under-explored sources of biological diversity.