Comparative Bioenergetics of Aging

衰老的比较生物能学

• 批准号: 10461869
• 负责人: STEVEN N. AUSTAD
• 金额: $ 89.27万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461869
• 关键词: Affect; Aging; Alabama; Animal Model; Animals; Assimilations; Autophagocytosis; Bioenergetics; Biology of Aging; Bivalvia; Body Composition; Brown Fat; Cell Aging; Cell Energetics; Cell Nucleus; Cell physiology; Cells; Chronic Disease; Collaborations; Communication; Communities; Comparative Biology; Complex; Country; DNA Repair; Data Analytics; Data Set; Discipline; Disease; Dissection; Education and Outreach; Elderly; Elephants; Environment; Expenditure; Experimental Designs; FRAP1 gene; Fishes; Fostering; Geroscience; Glycolysis; Goals; Health; Infrastructure; Instruction; Insulin; Intake; International; Laboratories; Life; Link; Longevity; Malignant Neoplasms; Mammals; Measurable; Metabolic; Metabolic Pathway; Metabolism; Methodology; Mitochondria; Mitochondrial DNA; Modeling; Modernization; Mole Rats; Morphology; Mus; Nuclear; Nutrient; Organ; Organelles; Organism; Oxidative Phosphorylation; Oxidative Stress; Oxygen; Pattern; Physical activity; Population; Process; Production; Rattus; Regulation; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Services; Shock; Signal Transduction; Techniques; Technology; Temperature; Tissues; Training Support; Training and Education; Twin Multiple Birth; Universities; Update; Variant; Whole Organism; body system; comparative; detection of nutrient; energy balance; experimental study; fly; gene network; health assessment; healthspan; innovation; instrumentation; interest; metabolic abnormality assessment; metabolic rate; metabolomics; novel; programs; proteostasis; reduced food intake; repaired; research and development; response; symposium; theories; tissue regeneration; virtual

Project Summary The University of Alabama at Birmingham (UAB) proposes to renew a Nathan Shock Center of Excellence in the Basic Biology of Aging focused on comparative bioenergetics and aging. Energetics is comprehensively defined for this purpose as the study of the causes, mechanisms, and consequences of the acquisition, storage, and utilization of metabolizable energy. Comparative energetics is the study of metabolic processes at multiple scales and across multiple species, in this case as it relates to health and aging. Nearly a century of aging research has reinforced the link between energetics and aging. In modern terms, this link is reified as dysregulated mitochondrial function, metabolic signaling, and nutrient responsiveness. The twin objectives of the Center will be to 1) explore in greater depth and detail than previously possible the complex relationship among cellular and organismal energetics and their relationship to whole organisms' energetics, health, and aging, and 2) provide quantitative, state-of-the-art technologies and novel methodologies in the assessment and analysis of bioenergetics to the geroscience community at large. In pursuit of these objectives, we will continue to provide three Research Cores. 1) The Comparative Organismal Energetics Core (a.k.a. Organismal Core) will provide expertise and cutting-edge instruction and methodology for determining complete whole-animal energy balance (intake, assimilation, and expenditure) and body composition, including regional distribution of white and brown adipose tissue, in living animals of various species, including worms, flies, fish, mice, or other mammals, under diverse temperature or activity regimes. 2) The Comparative Mitochondrial Health Assessment Core (a.k.a. Mitometabolism Core) will provide integrated, quantitative mitochondrial functional analysis at the level of the organelle, cell, or tissue for both traditional and emerging animal models, including targeted metabolomics, assessment of mitophagy, and oxidative stress. Mitochondrial-nuclear exchange models also will be available to enable experiments that evaluate the contribution of mtDNA variation to bioenergetics. 3) The Comparative Data Analytics Core (a.k.a. Analytics Core) will provide innovative analytic approaches to data sets linking comparative energetics to organismal health and longevity. With these Research Cores plus the Administrative Program Enrichment Core (Admin Core) and Research Development Core (RDC), we aim to: 1) facilitate hypothesis-driven research and leverage these technologies into new projects, interactions, and collaborations nationwide in basic aging research; 2) foster meaningful novel interactions among investigators within UAB and across the region and country; and 3) provide resources, education, training, and direction to junior investigators through the intellectual resources and research infrastructure the Center will develop.

项目概要 阿拉巴马大学伯明翰分校 (UAB) 提议更新内森肖克卓越中心 衰老基础生物学侧重于比较生物能学和衰老。能量学是全面的 为此目的定义为对收购的原因、机制和后果的研究， 代谢能的储存和利用。比较能量学是对代谢过程的研究 多个尺度和多个物种，在这种情况下，因为它与健康和衰老有关。近一个世纪的 衰老研究加强了能量学与衰老之间的联系。用现代术语来说，这个链接被具体化为 线粒体功能、代谢信号和营养反应失调。的双重目标 该中心将 1）比以前更深入、更详细地探索复杂的关系 细胞和有机体能量学之间及其与整个有机体的能量学、健康和 老龄化，2) 在评估中提供定量、最先进的技术和新颖的方法 以及对整个老年科学界的生物能量学分析。为了实现这些目标，我们将 继续提供三个研究核心。 1) 比较有机体能量核心（又名： 有机核心）将提供专业知识和前沿指导以及方法来确定 完整的整体动物能量平衡（摄入、同化和消耗）和身体成分，包括 各种物种的活体动物（包括蠕虫）中白色和棕色脂肪组织的区域分布， 苍蝇、鱼、小鼠或其他哺乳动物，在不同的温度或活动状态下。 2）比较 线粒体健康评估核心（又名线粒体代谢核心）将提供综合的、定量的 传统和新兴细胞器、细胞或组织水平的线粒体功能分析 动物模型，包括靶向代谢组学、线粒体自噬评估和氧化应激。 线粒体-核交换模型也将可用于评估线粒体核交换模型的实验 mtDNA 变异对生物能学的贡献。 3) 比较数据分析核心（又名分析） Core）将为将比较能量学与有机体联系起来的数据集提供创新的分析方法 健康长寿。 有了这些研究核心加上管理计划强化核心（管理核心）和研究 开发核心（RDC），我们的目标是：1）促进假设驱动的研究并利用这些技术 在全国范围内开展基础老龄化研究的新项目、互动和合作； 2）培养有意义的 UAB 内部以及整个地区和国家的研究人员之间的新颖互动； 3) 提供 通过智力资源和对初级研究人员的资源、教育、培训和指导 该中心将开发研究基础设施。