Exposure to metal mixtures in multiple critical periods of development and adolescent neuromotor function
Exposure to metal mixtures in multiple critical periods of development and adolescent neuromotor function
批准号:
10464009
负责人:
Alexa Friedman
金额:
$1.99万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-09-01 至 2022-10-16
关键词:
14 year oldAcademic achievementAdolescenceAdolescentAdverse effectsAffectAgeAnimalsAttentionBehaviorBiologicalBiological MarkersBiologyBloodBrainChemicalsChildChildhoodChromiumCognitionCognitiveConsensusCopperDataDevelopmentElementsEmotionalEnvironmental EpidemiologyEnvironmental HazardsExposure toFellowshipFunctional disorderFundingGoalsHairHandHealthHeterogeneityHumanIndividualIndustrial WasteIndustrializationIndustryInterventionItalyLeadLifeLinkManganeseMeasuresMentorshipMetal exposureMetalsMotorNail plateNational Institute of Environmental Health SciencesNeuraxisNeurodevelopmental DisorderNeuropsychological TestsOutcomePerformancePersonal SatisfactionPosturePredispositionPregnancyProductionProductivityPublic HealthQuality of lifeReportingResearchRoleSalivaSocial DevelopmentSocial InteractionSocietiesSoilSpeedStatistical MethodsTimeTooth structureToxic effectToxicologyTrainingTremorUnited States National Institutes of HealthUrineWorkagedbasebiomarker selectioncareercohortcommunity livingcritical perioddeciduous toothdexterityearly childhoodearly life exposureepidemiology studygirlshealth goalsin uteroinfancyinnovationinsightmetal poisoningmultidisciplinaryneurobehavioralneurodevelopmentneurotoxicitynovelpollutantprenatalprenatal exposuresecondary analysistoxicant
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
Evidence for neurodevelopmental toxicity from exposure to environmental metals is mounting. Recent studies
have found that neurotoxicity may depend on when during development the metal exposure occurs (e.g., in
utero versus childhood) and that metals have synergistic adverse effects on children's neurodevelopment. Our
study aims to elucidate the role of childhood environmental metal exposure on neuromotor function, a largely
understudied neurodevelopmental outcome, by examining cumulative and interactive associations with a
common industrial metal mixture. The proposed research in this F31 will use previously collected data from the
Public Health Impact of Mixed Element exposure (PHIME) study, comprised of 720 children (ages 10-14 years)
with varied airborne exposure to ferroalloy industry pollutants in Italy. Under the mentorship of a
multidisciplinary team of experts in environmental epidemiology, neurobehavioral toxicology, exposure biology,
statistical methods and chemical mixtures, Alexa Friedman (PI) proposes to estimate the associations of an
industrially relevant metal mixture of manganese, copper, chromium and lead with neuromotor function
in multiple critical periods of development. We will evaluate the relationship between metals, measured in
multiple biomarkers (teeth, hair, nails, blood, saliva, urine) that represent exposure from the prenatal period
through adolescence, and a battery of neuropsychological tests that evaluate motor function. We will use state-
of-the-art statistical approaches, including Bayesian Kernel Machine Regression and quantile-based g-
computation for metal mixtures, and hierarchical variable selection to examine biomarker selection. This
research will inform our current understanding of metal associations with children's neuromotor function and
provide insights for targeted interventions to reduce metals exposure. It also targets several NIEHS strategic
goals including the study of co-exposures in communities living near environmental hazards and the innovative
use of exposure data across critical developmental windows.
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