FASEB SRC: Skeletal Muscle Stem Cells and Regeneration

项目总结 本申请寻求对即将到来的美国实验学会联合会的部分支持 生物学(FASE B)会议，题为“骨骼肌干细胞和再生”，将于#月举行 2022年24日至28日，路易斯安那州新奥尔良。这将是第11届以成人为主题的会议 骨骼肌干细胞(MuSCs)和第10届由FASE B赞助。根据出勤记录从 前几年，我们预计来自世界各地的约175名与会者，其中约50%预计将 女性和约60%的初级研究人员。没有其他科学会议将主要焦点放在微卫星干细胞上。需要 对于一个以此为重点的会议，自会议以来出席人数的稳步增加就证明了这一点 会议初始阶段和与会者提供的一贯出色的会后评估。这次会议 吸引了来自世界各地的所有领先的MUSC研究人员，进一步展示了其对 以及该领域未来的领导者。 本次两年期会议的总体目标包括：1)全面分析最近的 该领域的发现，目的是了解控制正常和 肌间充质干细胞在肌肉内稳态、再生、肥大、衰老和肌病中的异常功能；2) 创造和促进交流思想和未公布数据的互动环境，以加快 发现并促进新的和现有的合作；3)为初级调查人员提供机会 介绍他们的工作和与高级调查人员的网络；以及4)促进妇女和 其他代表不足的群体，确保在会议方案的所有方面都有代表。 我们的主讲人将是爱德华·德·罗伯蒂斯博士，他是发育和干细胞生物学的先驱。八 计划举行会议，介绍48位演讲者(24位受邀演讲者和至少24位从提交的演讲者中挑选出来 摘要)在所有职业级别。会议主题包括：(1)骨髓间充质干细胞的分子调控；(2)干细胞和 疾病肌肉中的再生，(Iii)MUSC生态位和细胞信号，(Iv)MUSCs与 (V)肌肉再生的动力学，(Vi)工程和翻译 肌肉干细胞，(Vii)衰老中的肌肉动态平衡和再生，(Viii)肌肉中的新陈代谢和运动 再生。被邀请的演讲者是因为他们在科学上的卓越表现而被挑选出来的，并特别关注 妇女和少数群体的平等代表权和地域多样性。演讲者被明确要求 展示未发表的作品，以确保科学讨论处于该领域的前沿。我们会有四张海报 每一次会议之前都会有一场海报闪电战，选定的海报演示者将进行一分钟的演讲 突出他们的工作；以职业为导向的研讨会和“与专家见面”早餐和午餐会议。 这次会议将提供一个论坛，促进不同研究领域的讨论和交流， 以增进我们对肌肉再生的理解，并有助于治疗学的发展。

PROJECT SUMMARY This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, "Skeletal Muscle Stem Cells and Regeneration", which will be held July 24-28th, 2022 in New Orleans, Louisiana. This will be the 11th edition of this conference focusing on adult skeletal muscle stem cells (MuSCs) and the 10th sponsored by FASEB. Based on attendance records from previous years, we expect approximately 175 attendees from around the world of whom ~50% are expected to be women and ~60% junior researchers. No other scientific meeting has a primary focus on MuSCs. The need for a conference with this focus is demonstrated by the steady increase in attendance since the meeting's inception and the consistently excellent post-meeting evaluations provided by meeting attendees. This meeting attracts all leading MuSC researchers from around the world, further demonstrating its value for established and future leaders in the field. The overall objectives of this biennial meeting include: 1) to provide a comprehensive analysis of recent discoveries in the field, with the goal of understanding the regulatory mechanisms controlling normal and abnormal functions of MuSCs in muscle homeostasis, regeneration, hypertrophy, aging, and myopathy; 2) to create and foster an interactive environment for the exchange of ideas and unpublished data, so as to hasten discoveries and facilitate new and existing collaborations; 3) to provide opportunities for junior investigators to present their work and network with senior investigators; and 4) to facilitate career development of women and other underrepresented groups by ensuring representation in all aspects of the conference program. Our keynote speaker will be Dr. Edward De Robertis, a pioneer in development and stem cell biology. Eight sessions are planned, presenting 48 speakers (24 invited speakers and at least 24 selected from submitted abstracts) at all career levels. Session topics include: (i) molecular regulation of MuSCs, (ii) stem cells and regeneration in diseased muscle, (iii) the MuSC niche and cell signaling, (iv) interaction of MuSCs with, and regeneration of, the MTJ and the NMJ, (v) dynamics of muscle regeneration, (vi) engineering and translating MuSCs, (vii) muscle homeostasis and regeneration in aging, (viii) Metabolism and exercise in muscle regeneration. Invited speakers have been selected for their scientific excellence, with particular attention to equal representation of women and minorities and geographical diversity. Speakers are explicitly required to present unpublished work, to ensure scientific discussion is at the forefront of the field. We will have four poster sessions, each preceded by a “posters blitz” where selected poster presenters will give a one-minute talk to highlight their work; career-oriented workshops and “meet-the-expert” breakfast and lunch sessions. This meeting will provide a forum to foster discussion and cross-fertilization from diverse areas of research, to advance our understanding of muscle regeneration and help in the development of therapeutics.