FASEB SRC: Skeletal Muscle Stem Cells and Regeneration

FASEB SRC：骨骼肌干细胞和再生

• 批准号: 10464291
• 负责人: Addolorata Pisconti
• 金额: $ 2.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10464291
• 关键词: Adult; Aging; American; Animals; Area; Attention; Biology; Biomedical Engineering; Career Choice; Collaborations; Communities; Complex; Data; Development; Disease; Disease model; Educational workshop; Engineering; Ensure; Equilibrium; Evaluation; Exercise; Faculty; Fertilization; Food Industry; Fostering; Future; Gender; Genus Mentha; Geography; Goals; Growth; Health; Homeostasis; Human; Hypertrophy; Individual; Injections; International; Louisiana; Meat; Mentors; Metabolism; Minority; Molecular; Muscle; Muscle function; Muscle satellite cell; Muscular Dystrophies; Myopathy; Natural regeneration; Nervous system structure; Neuromuscular Junction; Organoids; Participant; Physiological; Policies; Property; Recording of previous events; Records; Regenerative capacity; Regulation; Research; Research Personnel; Role; Science; Scientist; Signal Transduction; Skeletal Muscle; Slide; Societies; Structure; Surveys; System; Therapeutic Intervention; Tissues; Translating; Underrepresented Minority; Underrepresented Populations; Woman; Work; base; bone; career; career development; career networking; cell behavior; collaborative environment; experience; graduate student; insight; interest; meetings; mid-career faculty; muscle aging; muscle engineering; muscle regeneration; novel; posters; professor; programs; regeneration following injury; regenerative; repaired; satellite cell; senescence; stem cell biology; stem cell niche; stem cell self renewal; stem cell therapy; stem cells; symposium; targeted treatment; therapeutic development; tool; unpublished works; virtual

PROJECT SUMMARY This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, "Skeletal Muscle Stem Cells and Regeneration", which will be held July 24-28th, 2022 in New Orleans, Louisiana. This will be the 11th edition of this conference focusing on adult skeletal muscle stem cells (MuSCs) and the 10th sponsored by FASEB. Based on attendance records from previous years, we expect approximately 175 attendees from around the world of whom ~50% are expected to be women and ~60% junior researchers. No other scientific meeting has a primary focus on MuSCs. The need for a conference with this focus is demonstrated by the steady increase in attendance since the meeting's inception and the consistently excellent post-meeting evaluations provided by meeting attendees. This meeting attracts all leading MuSC researchers from around the world, further demonstrating its value for established and future leaders in the field. The overall objectives of this biennial meeting include: 1) to provide a comprehensive analysis of recent discoveries in the field, with the goal of understanding the regulatory mechanisms controlling normal and abnormal functions of MuSCs in muscle homeostasis, regeneration, hypertrophy, aging, and myopathy; 2) to create and foster an interactive environment for the exchange of ideas and unpublished data, so as to hasten discoveries and facilitate new and existing collaborations; 3) to provide opportunities for junior investigators to present their work and network with senior investigators; and 4) to facilitate career development of women and other underrepresented groups by ensuring representation in all aspects of the conference program. Our keynote speaker will be Dr. Edward De Robertis, a pioneer in development and stem cell biology. Eight sessions are planned, presenting 48 speakers (24 invited speakers and at least 24 selected from submitted abstracts) at all career levels. Session topics include: (i) molecular regulation of MuSCs, (ii) stem cells and regeneration in diseased muscle, (iii) the MuSC niche and cell signaling, (iv) interaction of MuSCs with, and regeneration of, the MTJ and the NMJ, (v) dynamics of muscle regeneration, (vi) engineering and translating MuSCs, (vii) muscle homeostasis and regeneration in aging, (viii) Metabolism and exercise in muscle regeneration. Invited speakers have been selected for their scientific excellence, with particular attention to equal representation of women and minorities and geographical diversity. Speakers are explicitly required to present unpublished work, to ensure scientific discussion is at the forefront of the field. We will have four poster sessions, each preceded by a “posters blitz” where selected poster presenters will give a one-minute talk to highlight their work; career-oriented workshops and “meet-the-expert” breakfast and lunch sessions. This meeting will provide a forum to foster discussion and cross-fertilization from diverse areas of research, to advance our understanding of muscle regeneration and help in the development of therapeutics.

项目摘要 该申请寻求对即将到来的美国实验医学学会联合会的部分支持。 生物学（FASEB）会议，题为“骨骼肌干细胞和再生”，将于7月举行 2022年24日至28日在路易斯安那州新奥尔良市举行。这将是该会议的第11版，重点是成人 骨骼肌干细胞（MuSC）和FASEB赞助的第10届。根据2011年12月15日至2012年12月31日期间 前几年，我们预计约175与会者来自世界各地，其中约50%预计将 女性和约60%的初级研究人员。没有其他科学会议主要关注MuSC。需要 自会议召开以来，出席人数的稳步增加证明了这一点。 会议的开始和与会者提供的一贯出色的会后评价。本次会议 吸引了来自世界各地的所有领先的MuSC研究人员，进一步证明了其对建立 和未来的领导者。 这一两年期会议的总体目标包括：1）全面分析 该领域的发现，目的是了解控制正常和 MuSC在肌肉稳态、再生、肥大、衰老和肌病中的功能异常; 2） 创造和促进交流思想和未发表数据的互动环境，以加快 发现并促进新的和现有的合作; 3）为初级研究人员提供机会， 介绍其工作和与高级调查员的网络;以及4）促进妇女的职业发展， 其他代表性不足的群体，确保在会议计划的各个方面的代表性。 我们的主讲人将是Edward De Robertis博士，他是发展和干细胞生物学的先驱。八 会议计划，提出48个发言者（24个特邀发言者和至少24个从提交的 在所有职业水平。会议主题包括：（i）MuSC的分子调控，（ii）干细胞和 （iii）MuSC生态位和细胞信号传导，（iv）MuSC与 再生，MTJ和NMJ，（v）肌肉再生的动力学，（vi）工程和翻译 MuSC，（vii）衰老中的肌肉稳态和再生，（viii）肌肉中的代谢和运动 再生特邀演讲者是根据他们在科学方面的卓越表现而挑选出来的，特别关注 妇女和少数民族的平等代表性以及地域多样性。发言人被明确要求 目前未发表的工作，以确保科学讨论是在该领域的最前沿。我们会有四张海报 每节之前都有一个“海报闪电战”，在那里选定的海报主持人将给一个一分钟的演讲， 突出他们的工作;面向职业的讲习班和“会见专家”早餐和午餐会。 这次会议将提供一个论坛，促进不同研究领域的讨论和交流， 来促进我们对肌肉再生的理解，并帮助开发治疗方法。