FASEB SRC: Skeletal Muscle Stem Cells and Regeneration

FASEB SRC：骨骼肌干细胞和再生

• 批准号: 10464291
• 负责人: Addolorata Pisconti
• 金额: $ 2.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10464291
• 关键词: Adult; Aging; American; Animals; Area; Attention; Biology; Biomedical Engineering; Career Choice; Collaborations; Communities; Complex; Data; Development; Disease; Disease model; Educational workshop; Engineering; Ensure; Equilibrium; Evaluation; Exercise; Faculty; Fertilization; Food Industry; Fostering; Future; Gender; Genus Mentha; Geography; Goals; Growth; Health; Homeostasis; Human; Hypertrophy; Individual; Injections; International; Louisiana; Meat; Mentors; Metabolism; Minority; Molecular; Muscle; Muscle function; Muscle satellite cell; Muscular Dystrophies; Myopathy; Natural regeneration; Nervous system structure; Neuromuscular Junction; Organoids; Participant; Physiological; Policies; Property; Recording of previous events; Records; Regenerative capacity; Regulation; Research; Research Personnel; Role; Science; Scientist; Signal Transduction; Skeletal Muscle; Slide; Societies; Structure; Surveys; System; Therapeutic Intervention; Tissues; Translating; Underrepresented Minority; Underrepresented Populations; Woman; Work; base; bone; career; career development; career networking; cell behavior; collaborative environment; experience; graduate student; insight; interest; meetings; mid-career faculty; muscle aging; muscle engineering; muscle regeneration; novel; posters; professor; programs; regeneration following injury; regenerative; repaired; satellite cell; senescence; stem cell biology; stem cell niche; stem cell self renewal; stem cell therapy; stem cells; symposium; targeted treatment; therapeutic development; tool; unpublished works; virtual

PROJECT SUMMARY This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, "Skeletal Muscle Stem Cells and Regeneration", which will be held July 24-28th, 2022 in New Orleans, Louisiana. This will be the 11th edition of this conference focusing on adult skeletal muscle stem cells (MuSCs) and the 10th sponsored by FASEB. Based on attendance records from previous years, we expect approximately 175 attendees from around the world of whom ~50% are expected to be women and ~60% junior researchers. No other scientific meeting has a primary focus on MuSCs. The need for a conference with this focus is demonstrated by the steady increase in attendance since the meeting's inception and the consistently excellent post-meeting evaluations provided by meeting attendees. This meeting attracts all leading MuSC researchers from around the world, further demonstrating its value for established and future leaders in the field. The overall objectives of this biennial meeting include: 1) to provide a comprehensive analysis of recent discoveries in the field, with the goal of understanding the regulatory mechanisms controlling normal and abnormal functions of MuSCs in muscle homeostasis, regeneration, hypertrophy, aging, and myopathy; 2) to create and foster an interactive environment for the exchange of ideas and unpublished data, so as to hasten discoveries and facilitate new and existing collaborations; 3) to provide opportunities for junior investigators to present their work and network with senior investigators; and 4) to facilitate career development of women and other underrepresented groups by ensuring representation in all aspects of the conference program. Our keynote speaker will be Dr. Edward De Robertis, a pioneer in development and stem cell biology. Eight sessions are planned, presenting 48 speakers (24 invited speakers and at least 24 selected from submitted abstracts) at all career levels. Session topics include: (i) molecular regulation of MuSCs, (ii) stem cells and regeneration in diseased muscle, (iii) the MuSC niche and cell signaling, (iv) interaction of MuSCs with, and regeneration of, the MTJ and the NMJ, (v) dynamics of muscle regeneration, (vi) engineering and translating MuSCs, (vii) muscle homeostasis and regeneration in aging, (viii) Metabolism and exercise in muscle regeneration. Invited speakers have been selected for their scientific excellence, with particular attention to equal representation of women and minorities and geographical diversity. Speakers are explicitly required to present unpublished work, to ensure scientific discussion is at the forefront of the field. We will have four poster sessions, each preceded by a “posters blitz” where selected poster presenters will give a one-minute talk to highlight their work; career-oriented workshops and “meet-the-expert” breakfast and lunch sessions. This meeting will provide a forum to foster discussion and cross-fertilization from diverse areas of research, to advance our understanding of muscle regeneration and help in the development of therapeutics.

项目摘要 该申请为即将到来的实验社会联合会寻求部分支持 生物学（FASEB）会议标题为“骨骼肌干细胞和再生”，将于7月举行 2022年2月24日在路易斯安那州新奥尔良。这将是本次会议的第11版，重点是成人 骨骼肌干细胞（MUSC）和FASEB赞助的第10个。根据来自的出勤记录 往年，我们预计世界各地约有175名参与者，预计约50％ 是女性，约60％的初级研究人员。没有其他科学会议主要关注MUSC。需要 自从会议的出席人数稳定增加证明了以这种重点的会议以来 Inception和会议与会者提供的始终出色的会议后评估。这次会议 吸引了来自世界各地的所有领先的MUSC研究人员，进一步证明了其对既定的价值 和未来的领导者。 这两年一次的会议的总体目标包括：1）对最近的全面分析 该领域的发现，目的是了解控制正常和 MUSC在肌肉稳态，再生，肥大，衰老和肌病中的异常功能； 2）到 创建并培养一个交互式环境，以交换思想和未发表的数据，以加快 发现并促进新的和现有的合作； 3）为初级调查人员提供机会 向高级调查员介绍他们的工作和网络； 4）促进妇女的职业发展和 通过确保在会议计划的各个方面的代表性来代表其他代表性的小组。 我们的主题演讲者将是Edward de Robertis博士，他是开发和干细胞生物学的先驱。八 计划会议，展示48位发言人（24位受邀演讲者，至少有24位提交的演讲者 摘要）在所有职业水平上。会话主题包括：（i）MUSC的分子调节（II）干细胞和 （iii）musc的细胞和细胞信号传导的再生 MTJ和NMJ的再生，（V）肌肉再生动力学，（VI）工程和翻译 MUSC，（vii）肌肉稳态和衰老的再生，（VIII）代谢和运动 再生。被邀请的演讲者以其科学卓越的荣誉而被选中，特别关注 妇女和少数民族的平等代表以及地理多样性。说话者明确要求 目前未发表的工作，以确保科学讨论处于该领域的最前沿。我们将有四个海报 会议，每个会议先于“海报闪电”，其中选定的海报将与 突出他们的工作；以职业为导向的研讨会和“见面”早餐和午餐会议。 这次会议将提供一个论坛，以促进研究和跨批量研究的研究。 促进我们对肌肉再生的理解，并有助于发展治疗。