FASEB SRC: The Nuclear Bodies Conference: Hubs of Genomic Activity

项目摘要 这是2022年FASEB主办的科学研究会议“核”的部分支持申请 身体：基因组活动的枢纽”，第一次会议专门讨论这一主题。一个关键目标是提供一个 展示前沿、跨学科发现的平台，将核小体与癌症联系起来 生物学和真核基因组学。另一个主要目标是为博士后提供丰富的机会， 研究生学员，特别是妇女和科学界代表性不足的群体的成员， 他们的研究和从事职业发展和指导的机会。 核体是细胞生长和增殖所必需的，并且参与基因组组织和基因组分化。 基因表达的调控。值得注意的是，对这些机构的研究包括发展广泛有用的 基因组工具核体结构和功能的失调与发育密切相关。 异常、疾病和癌症，这些都是深刻的全球健康问题。对机制的兴趣 核小体的形成及其在正常和疾病状态中的作用在过去十年中有所加强。 因此，我们会议的主题既及时又具有高度相关性。 会议将提供一个独特的平台，汇集跨学科的专业知识，促进协同 以及对核物体的合作研究。我们亦会鼓励学员和初级学员， 调查员，并为所有参与者提供联网/协作机会。将有两张海报 会议和两项特别倡议，以促进与初级科学家的互动，包括职业指导 会议和一个“速度网络”的机会，年轻的科学家单独互动，建立教师。 三位协办者分别是Paul考夫曼博士（马萨诸塞州大学医学院教授）、Sui博士 Huang（西北大学医学院副教授）和Thoru Pederson博士（教授， 马萨诸塞州大学医学院）。他们坚定地致力于多样性和促进广泛的 女科学家、代表性不足的个人的研究人员、国际与会者的参与 和残疾人。我们已经确认了36位著名科学家的口头陈述，其中17位 其中10人是女性，4人是UI研究员，13人是国际同事。在选择口头摘要时， 在进行介绍时，将优先考虑新的研究者（特别是妇女和UIs）。事实上，100%的资金来自 该补助金将用于支持女性、初级和UI同事的参与：旅行奖励 对于25个由初级研究人员选择的摘要，儿童保育赠款，加上为这些参与者要求的资金， 旅行费用特别高或有其他特殊需要的团体。残疾人将拥有完整的 可以参加会议计划的各个方面，并提供儿童保育服务。

PROJECT SUMMARY This is an application for partial support of the 2022 FASEB-sponsored Science Research Conference “Nuclear Bodies: Hubs of Genome Activity”, the first meeting solely devoted to this topic. A key objective is to provide a platform for presentation of cutting-edge, interdisciplinary discoveries, connecting nuclear bodies to cancer biology and eukaryotic genomics. Another major objective is to provide abundant opportunities for postdoc and graduate student trainees, especially women and members of groups underrepresented in science, to present their research and to engage in career development and mentoring opportunities. Nuclear bodies are essential for cellular growth and proliferation, and are involved in genome organization and regulation of gene expression. Notably, study of these bodies has included the development of broadly useful genomic tools. Dysregulation of nuclear body structure and function is strongly associated with developmental abnormalities, diseases, and cancer, which are profound global health concerns. Interest in the mechanism of nuclear body formation and in their roles in normal and disease states have intensified over the past decade. Thus, the topic of our conference is both timely and highly relevant. The conference will provide a unique platform that brings together interdisciplinary expertise, fostering synergistic and cooperative investigations of nuclear bodies. We will also promote mentorship of trainees and junior investigators, and provide networking/collaboration opportunities for all participants. There will be two poster sessions and two special initiatives for stimulating interactions with junior scientists, including a Career Mentoring session and a “Speed Networking” opportunity for junior scientists to individually interact with established faculty. The three co-organizers are Dr. Paul Kaufman (Professor, University of Massachusetts Medical School), Dr. Sui Huang (Associate Professor, Northwestern University School of Medicine), and Dr. Thoru Pederson (Professor, University of Massachusetts Medical School). They are deeply committed to diversity and promotion of broad participation of women scientists, researchers from under-represented individuals (UIs), international attendees and persons with disabilities. We have confirmed oral presentations from 36 renowned scientists, of whom 17 are women, 4 are UI investigators, and 13 are international colleagues. In selecting abstracts for oral presentations, priority will be given to new investigators (especially women and UIs). Indeed, 100% funds from this grant will be allocated for supporting participation of women, junior and UI colleagues: travel awards for 25 chosen abstracts by junior investigators, child care grants, plus funds requested for participants in these groups with especially high travel costs or other special needs. Individuals with disabilities will have complete access to all aspects of the meeting program, and child-care services will be available.