FASEB SRC: The Nuclear Bodies Conference: Hubs of Genomic Activity

项目总结 这是一份申请2022年由FASEB主办的科学研究会议《核》的部分资助申请书 机构：基因组活动的中心“，这是专门讨论这一主题的第一次会议。一个关键目标是提供一个 展示前沿、跨学科发现的平台，将核体与癌症联系起来 生物学和真核基因组学。另一个主要目标是为博士后和 研究生实习生，特别是女性和在科学界任职人数不足的团体成员，以出席 他们的研究和从事职业发展和指导的机会。 核体对细胞的生长和增殖是必不可少的，并参与基因组的组织和 基因表达的调控。值得注意的是，对这些机构的研究包括制定了广泛有用的 基因组工具。核体结构和功能的失调与发育密切相关 异常、疾病和癌症，这些都是严重的全球卫生问题。对机制的兴趣 在过去的十年里，核体的形成及其在正常和疾病状态中的作用都有所加强。 因此，我们这次会议的议题既及时又具有高度相关性。 会议将提供一个独特的平台，汇聚跨学科的专业知识，促进协同 以及对核机构的合作调查。我们还将促进学员和青少年的导师关系。 调查人员，并为所有参与者提供网络/协作机会。会有两张海报 会议和促进与初级科学家互动的两项特别倡议，包括职业指导 会议和“快速联网”机会，为初级科学家提供单独与知名教员互动的机会。 三位联合主办者分别是Paul Kaufman博士(麻省大学医学院教授)、Sui博士 黄(西北大学医学院副教授)和Thoru Pederson博士(教授， 马萨诸塞大学医学院)。他们坚定地致力于多样性和推广广泛的 女科学家、任职人数不足个人的研究人员、国际与会者的参与 和残疾人。我们已经确认了36位著名科学家的口头陈述，其中17位 其中4人是女性，4人是调查人员，13人是国际同事。在选择口述摘要时 在介绍情况时，将优先考虑新的调查人员(特别是妇女和统计研究所)。事实上，100%的资金来自 这笔赠款将用于支持妇女、初级和统筹部同事的参与：旅行奖励 对于初级调查人员选定的25篇摘要，儿童保育补助金，以及为这些摘要的参与者申请的资金 旅行费用特别高或有其他特殊需求的群体。残疾人士将拥有完整的 会议计划的所有方面都可以使用，儿童保育服务也将提供。

PROJECT SUMMARY This is an application for partial support of the 2022 FASEB-sponsored Science Research Conference “Nuclear Bodies: Hubs of Genome Activity”, the first meeting solely devoted to this topic. A key objective is to provide a platform for presentation of cutting-edge, interdisciplinary discoveries, connecting nuclear bodies to cancer biology and eukaryotic genomics. Another major objective is to provide abundant opportunities for postdoc and graduate student trainees, especially women and members of groups underrepresented in science, to present their research and to engage in career development and mentoring opportunities. Nuclear bodies are essential for cellular growth and proliferation, and are involved in genome organization and regulation of gene expression. Notably, study of these bodies has included the development of broadly useful genomic tools. Dysregulation of nuclear body structure and function is strongly associated with developmental abnormalities, diseases, and cancer, which are profound global health concerns. Interest in the mechanism of nuclear body formation and in their roles in normal and disease states have intensified over the past decade. Thus, the topic of our conference is both timely and highly relevant. The conference will provide a unique platform that brings together interdisciplinary expertise, fostering synergistic and cooperative investigations of nuclear bodies. We will also promote mentorship of trainees and junior investigators, and provide networking/collaboration opportunities for all participants. There will be two poster sessions and two special initiatives for stimulating interactions with junior scientists, including a Career Mentoring session and a “Speed Networking” opportunity for junior scientists to individually interact with established faculty. The three co-organizers are Dr. Paul Kaufman (Professor, University of Massachusetts Medical School), Dr. Sui Huang (Associate Professor, Northwestern University School of Medicine), and Dr. Thoru Pederson (Professor, University of Massachusetts Medical School). They are deeply committed to diversity and promotion of broad participation of women scientists, researchers from under-represented individuals (UIs), international attendees and persons with disabilities. We have confirmed oral presentations from 36 renowned scientists, of whom 17 are women, 4 are UI investigators, and 13 are international colleagues. In selecting abstracts for oral presentations, priority will be given to new investigators (especially women and UIs). Indeed, 100% funds from this grant will be allocated for supporting participation of women, junior and UI colleagues: travel awards for 25 chosen abstracts by junior investigators, child care grants, plus funds requested for participants in these groups with especially high travel costs or other special needs. Individuals with disabilities will have complete access to all aspects of the meeting program, and child-care services will be available.