Levelling up: Cultured meat bioprocess intensification for scalable commercial production

升级：培养肉生物加工强化以实现可扩展的商业生产

• 批准号: 10083870
• 金额: $ 34.73万
• 依托单位: ROSLIN TECHNOLOGIES LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10083870
• 关键词: Levelling; up; Cultured; meat; bioprocess

Cultured Meat offers enormous potential for addressing concerns around sustainability, animal welfare and environmental impact of the traditional meat industry. However, technoeconomic challenges remain in scaling production to meet market demand, estimated to reach $20Bn by 2030\.Cultured meat is produced by directly culturing animal cells. This production method eliminates the need to raise and farm animals for food, meaning that cultured meat production has a considerably lower environmental impact than its conventional counterpart. Cultured meat consists of the same cell types that can be arranged in the same structure as animal tissues to replicate the taste, texture and nutritional profiles of conventional meat.Producing cultured meat can be challenging due to longevity of most cell lines and their abilities to differentiate into required cell types, including muscle and fat.Roslin Technologies (RTL) are the first and leading provider of high quality cell lines for the cultivated meat sector. We develop induced pluripotent stem cell lines (iPSC) that can differentiate into muscle and fat, supported by customised cell culture media and processes. Our cells are well suited to the cultured meat industry as they are non-GMO, grow quickly, are genetically stable and can grow in suspension culture without the need for additional scaffolds. At RTL we have demonstrated our cells can grow in small-scale benchtop bioreactors, but the next step is to transfer this to industry relevant pilot-scale bioreactors.With Innovate UK and Innosuisse support RTL are excited to partner with The Cultured Hub (TCH) in Kemptthal, Switzerland. TCH is a dedicated cultured meat contract development and manufacturing organisation (CDMO) that provides expertise in process intensification and scale-up. In this project RTL and TCH will work together to realise the full potential of RTL stem cells. Researchers will work to optimise cell yields, quality and safety through media and bioprocess development. The data and know how generated by this project will help demonstrate the commercial potential of RTL cells and position TCH as a leading CDMO for cultured meat bioprocess development. The projects focus on cultured meat safety will also provide valuable information to regulators and policy makers to help define UK CM quality and safety standards. We believe this will benefit cultured meat producers and the industry as a whole to reach mass consumer markets faster. Ultimately this will support a more resilient food system and contribute to Paris Agreement goals and the UN Framework Convention on Climate Change.

培养的肉类为解决传统肉类行业的可持续性，动物福利和环境影响的关注提供了巨大的潜力。但是，技术经济的挑战仍在扩展生产中以满足市场需求，估计到2030年\ 2030 \。培养的肉是通过直接培养动物细胞产生的。这种生产方法消除了为食物养育和养殖动物的需求，这意味着培养的肉类生产的环境影响要比其传统的对应物要低得多。培养的肉由相同的细胞类型组成，可以与动物组织相同的结构排列，以复制传统肉类的味道，质地和营养曲线。生产培养的肉可能会具有挑战性，因为大多数细胞系的寿命及其能力及其能力差异化，以区分肌肉和Fat.Roslin.Roslin.Roslin.Rosloslin。我们开发了诱导的多能干细胞系（IPSC），这些干细胞系（IPSC）可以通过定制的细胞培养基和过程来支持肌肉和脂肪。我们的细胞非常适合培养的肉类工业，因为它们是非基因生物，迅速生长，具有遗传稳定，并且可以在悬浮培养中生长，而无需其他脚手架。在RTL，我们已经证明了我们的细胞可以在小规模的台式生物反应器中生长，但是下一步是将其转移到相关的相关飞行员尺度的生物反应器中。与Innovate Innovate UK和Innosuisse Support RTL RTL对与瑞士Kemptthal的培养枢纽（TCH）合作感到兴奋。 TCH是一个专门的培养肉类合同开发和制造组织（CDMO），可提供过程加强和扩大规模的专业知识。在这个项目中，RTL和TCH将共同实现RTL干细胞的全部潜力。研究人员将通过媒体和生物处理开发来优化细胞产量，质量和安全性。数据并知道该项目产生的方式将有助于证明RTL细胞的商业潜力，并将TCH作为培养的肉类生物过程开发的主要CDMO。这些项目专注于培养的肉类安全，还将为监管机构和政策制定者提供有价值的信息，以帮助定义英国CM质量和安全标准。我们认为，这将使培养的肉类生产商和整个行业受益，以更快地到达大众消费市场。最终，这将支持更具弹性的食品系统，并为巴黎协定目标和《联合国气候变化框架公约》做出贡献。