PRODUCTION OF B6C3F1/N MICE FOR NTP STUDIES

国家环境健康科学研究所（NIEHS）下属的国家毒理学计划（DNTP）是一个跨部门计划，其任务是通过开发和应用现代毒理学和分子生物学工具来评估公共卫生关注的因素。该计划在处理毒理学中的关键问题时保持客观，以科学为基础的方法，并致力于使用最好的科学来优先考虑，设计，实施和解释其研究。对化学品和其他药剂的评价通常是通过一系列研究进行的，这些研究涉及让实验室啮齿动物接触这些药剂。大鼠和小鼠是评估这些化合物的毒理学和致癌潜力的合适模型。NTP利用B6C3F1/N杂交小鼠来评估这种潜力。该合同支持B6C3F1/N小鼠NTP菌落的生产。执行了6个月的延长选项，因此PoP为21年9月30日- 22年3月31日。

The Division of the National Toxicology Program (DNTP) within the National Institute of Environmental Health Sciences (NIEHS), is an interagency program whose mission is to evaluate agents of public health concern by developing and applying tools of modern toxicology and molecular biology. The program maintains an objective, science-based approach in dealing with critical issues in toxicology and is committed to using the best science available to prioritize, design, conduct, and interpret its studies. The evaluation of chemicals and other agents is generally conducted through a sequence of studies, which involve the exposure of laboratory rodents to these agents. Rats and mice are appropriate models for evaluating the toxicologic and carcinogenic potential of these compounds. The NTP utilizes the B6C3F1/N hybrid mouse to evaluate this potential. This contract supports the production of the NTP colony of B6C3F1/N mice. The 6-month extension option was executed so the PoP is 9/30/21 – 3/31/22.