IGF:OT:IGF PRODUCTION OF B6C3F1 MICE FOR NTP STUDIES

用于 NTP 研究的 B6C3F1 小鼠的 IGF:OT:IGF 生产

• 批准号: 8947872
• 负责人: JEFFREY LOHMILLER
• 金额: $ 90.03万
• 依托单位: TACONIC BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2014-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8947872
• 关键词: Animals; Chemicals; Contracts; Disease; Ensure; Genetic; Health; Hybrids; Laboratories; Maintenance; Monitor; Mus; National Toxicology Program; Production; Property; Rodent; Testing; microbial; pathogen; programs

The National Toxicology Program (NTP) utilizes the B6C3F1 hybrid mouse to evaluate the toxicologic and carcinogenic potential of chemicals and other agents. Centralized colonies of C57BL/6N (e84) and C3H/HeN MTV- (e84) mice with homogeneous genetic properties and defined microbial status will ensure an adequate and continuous supply of quality animals for the NTP testing program. The purpose of this contract is to establish, operate and maintain rodent production colonies under strict barrier conditions, in order to produce a large number of disease-free, genetically homogeneous, B6C3F1 mice to be used by testing laboratories performing NTP studies.

国家毒理学计划（NTP）利用B6C3F1杂交小鼠来评估化学品和其他试剂的毒理学和致癌潜力。C57BL/6N （e84）和C3H/HeN MTV- (e84)小鼠的集中菌落具有均匀的遗传特性和明确的微生物状态，将确保NTP测试计划提供足够和持续的优质动物。该合同的目的是在严格的屏障条件下建立、操作和维持啮齿动物生产菌落，以便生产大量无病、基因同质的B6C3F1小鼠，供进行NTP研究的测试实验室使用。