IGF:OT:IGF PRODUCTION OF B6C3F1 MICE FOR NTP STUDIES

国家毒理学计划（NTP）利用B6 C3 F1杂交小鼠来评估化学品和其他试剂的毒理学和致癌潜力。具有同质遗传特性和确定微生物状态的C57 BL/6 N（e84）和C3 H/HeN MTV-（e84）小鼠的集中菌落将确保为NTP检测项目提供充足和持续的优质动物。本合同的目的是在严格的屏障条件下建立、操作和维护啮齿动物生产群，以生产大量无病、遗传同质的B6 C3 F1小鼠，供进行NTP研究的检测实验室使用。

The National Toxicology Program (NTP) utilizes the B6C3F1 hybrid mouse to evaluate the toxicologic and carcinogenic potential of chemicals and other agents. Centralized colonies of C57BL/6N (e84) and C3H/HeN MTV- (e84) mice with homogeneous genetic properties and defined microbial status will ensure an adequate and continuous supply of quality animals for the NTP testing program. The purpose of this contract is to establish, operate and maintain rodent production colonies under strict barrier conditions, in order to produce a large number of disease-free, genetically homogeneous, B6C3F1 mice to be used by testing laboratories performing NTP studies.