PRODUCTION OF B6C3F1/N MICE FOR NTP STUDIES

用于 NTP 研究的 B6C3F1/N 小鼠的生产

• 批准号: 10262900
• 负责人: JEFFREY LOHMILLER
• 金额: $ 60万
• 依托单位: TACONIC BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2021-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10262900
• 关键词: Animals; Chemicals; Contracts; Disease; Evaluation; Genetic; Hybrids; Laboratories; Mission; Modeling; Modernization; Molecular Biology; Mouse Strains; Mus; National Institute of Environmental Health Sciences; National Toxicology Program; Production; Public Health; Rattus; Rodent; Science; Support Contracts; Toxicology; base; carcinogenicity; design; programs; tool

The Division of the National Toxicology Program (DNTP) within the National Institute of Environmental Health Sciences (NIEHS), is an interagency program whose mission is to evaluate agents of public health concern by developing and applying tools of modern toxicology and molecular biology. The program maintains an objective, science-based approach in dealing with critical issues in toxicology and is committed to using the best science available to prioritize, design, conduct, and interpret its studies. The evaluation of chemicals and other agents is generally conducted through a sequence of studies, which involve the exposure of laboratory rodents to these agents. Rats and mice are appropriate models for evaluating the toxicologic and carcinogenic potential of these compounds. The NTP utilizes the B6C3F1/N hybrid mouse to evaluate this potential. This contract supports the production of the NTP colony of B6C3F1/N mice.

国家环境卫生科学研究所（NIEHS）内的国家毒理学计划部（DNTP）是一个跨部门计划，其使命是通过开发和应用现代毒理学和分子生物学工具来评估公共卫生关注的物质。该计划在处理毒理学中的关键问题时保持客观，以科学为基础的方法，并致力于使用最好的科学来优先考虑，设计，进行和解释其研究。 对化学品和其他制剂的评价通常通过一系列研究进行，这些研究涉及实验室啮齿动物对这些制剂的暴露。 大鼠和小鼠是评价这些化合物的毒理学和致癌潜力的适当模型。 NTP利用B6 C3 F1/N杂交小鼠来评价这种潜力。 该合同支持B6 C3 F1/N小鼠的NTP集落的生产。