Evaluation of ACT1 to Treat Diabetic Keratopathy
ACT1 治疗糖尿病角膜病的评价
基本信息
- 批准号:10470634
- 负责人:
- 金额:$ 121.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:ADME StudyBindingBlindnessBurn injuryC-terminalCellsCollaborationsConnexin 43CorneaCorneal InjuryDefectDevelopmentDiabetes MellitusDiseaseDrug KineticsEpithelialEthanolEvaluationExtravasationFibrosisFormulationGranulation TissueHumanImmuneIndividualInjuryInvestigational DrugsKeratopathyLeadMediator of activation proteinMorbidity - disease ratePeptidesPharmaceutical PreparationsPlayPre-Clinical ModelRoleSafetySignal TransductionTherapeuticThinnessToxicologyTreatment ProtocolsVisual impairmentbaseconventional therapycorneal burndesigndiabeticdiabetic ratepithelial woundphase 1 studyresearch clinical testingsafety studywound closurewound healing
项目摘要
FirstStrings lead peptide, ACT1, is based on the C-terminal sequence of connexin43 (Cx43) and is designed to enter the cell and competitively inhibit the binding of endogenous Cx43. Cx43 plays critical roles in multiple aspects of wound healing, including spread of injury signals, extravasation of immune cells, granulation tissue formation, and fibrosis.
Studies in preclinical models of efficacy show significant enhancement in corneal re-epithelialization and wound closure following ethanol-induced corneal burn injuries in diabetic rats, as compared with controls. This project will involve further development and safety studies of ACT1, a potential therapeutic compound for diabetic keratopathy.
The BrIDGs team is collaborating on the completion of the following studies on ACT1:
- Formulation development and manufacture of drug product to support Phase I studies
- Pharmacokinetic/absorption, distribution, metabolism, and excretion (PK/ADME) studies
- Investigational New Drug (IND)-directed toxicology
FirstStrings的前导肽ACT1基于connexin43 (Cx43)的c端序列,旨在进入细胞并竞争性地抑制内源性Cx43的结合。Cx43在伤口愈合的多个方面发挥关键作用,包括损伤信号的传播、免疫细胞的外渗、肉芽组织的形成和纤维化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Donald Lo其他文献
Donald Lo的其他文献
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{{ truncateString('Donald Lo', 18)}}的其他基金
Studies of Tumor-Penetrating Microparticles for Pancreatic Cancer
肿瘤穿透微粒治疗胰腺癌的研究
- 批准号:
10470633 - 财政年份:
- 资助金额:
$ 121.52万 - 项目类别:
Studies of Tumor-Penetrating Microparticles for Pancreatic Cancer
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10686744 - 财政年份:
- 资助金额:
$ 121.52万 - 项目类别:
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COVID-19:识别和开发治疗 SARS-CoV-2 的临床候选药物
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10686748 - 财政年份:
- 资助金额:
$ 121.52万 - 项目类别:
HDAC/PI3K Dual Inhibitors for Treatment of Rare Cancers
HDAC/PI3K 双重抑制剂治疗罕见癌症
- 批准号:
10259368 - 财政年份:
- 资助金额:
$ 121.52万 - 项目类别:
COVID-19: Identification and Development of Clinical Candidates to Treat SARS-CoV-2
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10259371 - 财政年份:
- 资助金额:
$ 121.52万 - 项目类别:
Development of Nogo Receptor Decoy for the Treatment of Spinal Cord Injury
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$ 121.52万 - 项目类别:
HDAC/PI3K Dual Inhibitors for Treatment of Rare Cancers
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- 批准号:
10686743 - 财政年份:
- 资助金额:
$ 121.52万 - 项目类别:
HEAL: Development of Clinical Candidate Drugs for Pain, Addiction and Overdose
HEAL:开发治疗疼痛、成瘾和药物过量的临床候选药物
- 批准号:
10259369 - 财政年份:
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$ 121.52万 - 项目类别:
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