FASEB SRC: Matricellular Proteins: Fundamental Concepts and New Directions
FASEB SRC: Matricellular Proteins: Fundamental Concepts and New Directions
批准号:
10468385
负责人:
Kurt David Hankenson
金额:
$0.8万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-06-01 至 2023-05-31
关键词:
AcademiaAdhesionsAgingApoptosisArthritisBindingBiological ProcessBiologyCardiovascular DiseasesCareer MobilityCartilageCategoriesCell AdhesionCell Adhesion ProcessCell CommunicationCell Cycle ProgressionCell ProliferationCell Surface ReceptorsCell physiologyCell surfaceCellsCollaborationsCollagenCommunitiesComplexCysteineDevelopmentDiseaseEducational workshopEnvironmentExtracellular MatrixExtracellular Matrix ProteinsExtracellular ProteinFamilyFamily memberFosteringFutureGene ExpressionGene FamilyGoalsGovernmentGrowth FactorGrowth and Development functionIndustryInfectionInflammationLeftLigamentsMalignant NeoplasmsMechanicsMentorshipMetabolismMolecularMusculoskeletal SystemNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNatural regenerationNon-Insulin-Dependent Diabetes MellitusOrganOsteoporosisPathologicPathologyPeptide HydrolasesPhenotypePhysiological ProcessesPortugalProtein FamilyProteinsReactive Oxygen SpeciesReceptor CellRegulationResearchResearch PersonnelRetinal DegenerationRoleScientistSet proteinSignal TransductionSkinStructureTenascinTendinopathyTendon structureThrombospondinsTimeTissuesUniversitiesWashingtonWorkbonecareer developmentcell growth regulationcytokinedesignfibulinfunctional groupmeetingsmembermigrationperiostinpostersreceptorrepairedresponsesymposiumtrait
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Matricellular proteins (MPs) are key component proteins of the extracellular matrix that are integral to
modulating cell physiology. Through binding to cellular receptors, growth factors, and other ECM components
this functional group of proteins regulates development and growth, regeneration, pathology, cancer, and
aging. MPs are broadly expressed in many tissues, and have recognized roles in a variety of
disease/pathological conditions, including, arthritis, osteoporosis, tendinopathy, type II diabetes, cardiovascular
disease, retinal degeneration, cancer and metasis. We are seeking support for the 7th triennial FASEB SRC
matricellular protein conference, titled “Matricelluar Proteins: Fundamental Concepts and New Directions”.
The focus of this meeting which will be held in the summer of 2022 is to bring together a diverse group of
established and new investigators. Our goal is to rediscover what it means for a protein to be considered a
matricellular protein, and to lay a path to define the future of the field. While there are a set of proteins that are
considered prototypical matricellular proteins, many new proteins that are secreted and multifunctional can
also be considered MP. Considering these new proteins in the framework of the matricellular concept can help
new investigators to advance their research. A plenary session will kick-off the meeting and will include a
keynote speaker. This session will introduce the concepts of cell adhesion, growth factor binding, adhesion-de-
adheision, and matrix-matrix interactions – canonical functions that define matricellular proteins. Over the
subsequent four days, two sessions per day, each day will be focused on expanding one of these concepts.
Morning sessions will focus on the aforementioned concepts, and the afternoon sessions will be focused on
protein family specific presentations. Wednesday will include a 2nd keynote speaker. While most of the invited
speakers and all of the session chairs have been invited and committed, we have left open speaker slots in
most sessions in order to invite ‘up and coming’ scientists – trainee and early-stage investigators – with
exciting new work over the next 6 months. We will request abstract submissions and two abstracts will be
selected from each submitted abstract for presentation in six of the nine sessions and then there will be two
poster sessions. Additional career development activities will include mentorship/mentee opportunities, career
development workshops, and MP specific question/answer sessions.
The organizers have been and will continue to be highly focused on fostering an inclusive environment. Both
new investigators to the field and long-standing members of the MP community will attend the meeting and
actively participate in this meeting, and be drawn from academia, government, and industry.
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海外基金