FASEB SRC: Matricellular Proteins: Fundamental Concepts and New Directions

基质细胞蛋白(MPS)是细胞外基质的关键组成蛋白，是 调节细胞生理学。通过与细胞受体、生长因子和其他细胞外基质成分结合 这种蛋白质的功能群调节发育和生长、再生、病理、癌症和 衰老。MPS在许多组织中广泛表达，并在多种组织中发挥作用。 疾病/病理状况，包括关节炎、骨质疏松症、肌腱病、II型糖尿病、心血管疾病 疾病、视网膜退化、癌症和转移。我们正在为第七届三年一度的FASE B SRC寻求支持 基质细胞蛋白质会议，题为“基质细胞蛋白质：基本概念和新方向”。 这次会议将于2022年夏天举行，会议的重点是将不同的团体聚集在一起 现有的和新的调查人员。我们的目标是重新发现蛋白质被认为是 并为定义该领域的未来铺平了道路。虽然有一组蛋白质是 被认为是典型的母细胞蛋白质，许多新的分泌和多功能的蛋白质可以 也被认为是国会议员。在母细胞概念的框架内考虑这些新蛋白质可能会有所帮助 新的研究人员来推进他们的研究。全体会议将拉开会议的序幕，并将包括 主旨发言人。本课程将介绍细胞黏附、生长因子结合、黏附-去黏附的概念。 粘附性和基质-基质相互作用--定义基质细胞蛋白质的典型功能。超过了 随后的四天，每天两次会议，每天都将集中讨论扩展其中一个概念。 上午的会议将集中讨论上述概念，下午的会议将集中讨论 蛋白质家族的特定介绍。周三将包括第二位主旨演讲者。虽然大多数被邀请的人 演讲者和所有会议主席已被邀请并承诺，我们在#年留出了演讲者的空位。 大多数会议都是为了邀请“新锐”科学家--见习科学家和早期研究人员--与 在接下来的6个月里有令人兴奋的新工作。我们将要求提交摘要，两个摘要将是 从每个提交的摘要中挑选出来，在九个会议中的六个会议上发表，然后将有两个 海报会议。其他职业发展活动将包括导师/被辅导者机会、职业 发展讲习班和MP特定问题/回答会议。 组织者一直高度重视促进包容性环境，今后也将继续如此。两者都有 新到现场的调查人员和国会议员社区的长期成员将出席会议并 积极参与本次会议，吸纳学术界、政界、产业界人士参加。

Matricellular proteins (MPs) are key component proteins of the extracellular matrix that are integral to modulating cell physiology. Through binding to cellular receptors, growth factors, and other ECM components this functional group of proteins regulates development and growth, regeneration, pathology, cancer, and aging. MPs are broadly expressed in many tissues, and have recognized roles in a variety of disease/pathological conditions, including, arthritis, osteoporosis, tendinopathy, type II diabetes, cardiovascular disease, retinal degeneration, cancer and metasis. We are seeking support for the 7th triennial FASEB SRC matricellular protein conference, titled “Matricelluar Proteins: Fundamental Concepts and New Directions”. The focus of this meeting which will be held in the summer of 2022 is to bring together a diverse group of established and new investigators. Our goal is to rediscover what it means for a protein to be considered a matricellular protein, and to lay a path to define the future of the field. While there are a set of proteins that are considered prototypical matricellular proteins, many new proteins that are secreted and multifunctional can also be considered MP. Considering these new proteins in the framework of the matricellular concept can help new investigators to advance their research. A plenary session will kick-off the meeting and will include a keynote speaker. This session will introduce the concepts of cell adhesion, growth factor binding, adhesion-de- adheision, and matrix-matrix interactions – canonical functions that define matricellular proteins. Over the subsequent four days, two sessions per day, each day will be focused on expanding one of these concepts. Morning sessions will focus on the aforementioned concepts, and the afternoon sessions will be focused on protein family specific presentations. Wednesday will include a 2nd keynote speaker. While most of the invited speakers and all of the session chairs have been invited and committed, we have left open speaker slots in most sessions in order to invite ‘up and coming’ scientists – trainee and early-stage investigators – with exciting new work over the next 6 months. We will request abstract submissions and two abstracts will be selected from each submitted abstract for presentation in six of the nine sessions and then there will be two poster sessions. Additional career development activities will include mentorship/mentee opportunities, career development workshops, and MP specific question/answer sessions. The organizers have been and will continue to be highly focused on fostering an inclusive environment. Both new investigators to the field and long-standing members of the MP community will attend the meeting and actively participate in this meeting, and be drawn from academia, government, and industry.