FASEB SRC: Matricellular Proteins: Fundamental Concepts and New Directions

基质细胞蛋白（MP）是细胞外基质的关键组分蛋白，其是细胞外基质的组成部分。 调节细胞生理学通过与细胞受体、生长因子和其他ECM成分结合 这一功能性蛋白质组调节发育和生长、再生、病理学、癌症， 衰老MP在许多组织中广泛表达，并且在多种组织中具有公认的作用。 疾病/病理状况，包括关节炎、骨质疏松症、肌腱病、II型糖尿病、心血管 疾病、视网膜变性、癌症和转移。我们正在寻求对第七届三年一度的FASEB SRC的支持 Matricelluar Proteins：Fundamental Concepts and New Directions（基质细胞蛋白质：基本概念和新方向） 将于2022年夏季举行的这次会议的重点是汇集一个多元化的团体， 新的和新的调查员。我们的目标是重新发现一种蛋白质被认为是 基质细胞蛋白，并奠定了一条道路，以确定该领域的未来。虽然有一组蛋白质 被认为是原型的基质细胞蛋白质，许多新的分泌的和多功能的蛋白质， 也被认为是MP。在基质细胞概念的框架内考虑这些新蛋白质有助于 新的研究人员来推进他们的研究。全体会议将启动会议，并将包括一个 主讲人。本节将介绍细胞粘附、生长因子结合、粘附-脱- 粘附和基质-基质相互作用-定义基质细胞蛋白的典型功能。来 随后的四天，每天两次会议，每天将侧重于扩大这些概念之一。 上午的会议将侧重于上述概念，下午的会议将侧重于 蛋白质家族特异性表达。星期三将有第二位主讲人。虽然大多数被邀请的 发言人和所有会议主席都已被邀请并承诺，我们在 大多数会议都是为了邀请“崭露头角”的科学家--实习生和早期研究人员-- 在接下来的六个月里，我们将进行令人兴奋的新工作。我们将要求提交摘要，并将提交两份摘要 从每个提交的摘要中选出，在九个会议中的六个会议上发表，然后将有两个 海报会议。其他职业发展活动将包括导师/学员机会、职业发展和职业发展。 发展讲习班和《蒙特利尔议定书》具体问题/回答会议。 组织者一直并将继续高度重视营造包容性环境。两 新的实地调查人员和MP社区的长期成员将出席会议， 积极参加这次会议，并从学术界，政府和工业界吸收。

Matricellular proteins (MPs) are key component proteins of the extracellular matrix that are integral to modulating cell physiology. Through binding to cellular receptors, growth factors, and other ECM components this functional group of proteins regulates development and growth, regeneration, pathology, cancer, and aging. MPs are broadly expressed in many tissues, and have recognized roles in a variety of disease/pathological conditions, including, arthritis, osteoporosis, tendinopathy, type II diabetes, cardiovascular disease, retinal degeneration, cancer and metasis. We are seeking support for the 7th triennial FASEB SRC matricellular protein conference, titled “Matricelluar Proteins: Fundamental Concepts and New Directions”. The focus of this meeting which will be held in the summer of 2022 is to bring together a diverse group of established and new investigators. Our goal is to rediscover what it means for a protein to be considered a matricellular protein, and to lay a path to define the future of the field. While there are a set of proteins that are considered prototypical matricellular proteins, many new proteins that are secreted and multifunctional can also be considered MP. Considering these new proteins in the framework of the matricellular concept can help new investigators to advance their research. A plenary session will kick-off the meeting and will include a keynote speaker. This session will introduce the concepts of cell adhesion, growth factor binding, adhesion-de- adheision, and matrix-matrix interactions – canonical functions that define matricellular proteins. Over the subsequent four days, two sessions per day, each day will be focused on expanding one of these concepts. Morning sessions will focus on the aforementioned concepts, and the afternoon sessions will be focused on protein family specific presentations. Wednesday will include a 2nd keynote speaker. While most of the invited speakers and all of the session chairs have been invited and committed, we have left open speaker slots in most sessions in order to invite ‘up and coming’ scientists – trainee and early-stage investigators – with exciting new work over the next 6 months. We will request abstract submissions and two abstracts will be selected from each submitted abstract for presentation in six of the nine sessions and then there will be two poster sessions. Additional career development activities will include mentorship/mentee opportunities, career development workshops, and MP specific question/answer sessions. The organizers have been and will continue to be highly focused on fostering an inclusive environment. Both new investigators to the field and long-standing members of the MP community will attend the meeting and actively participate in this meeting, and be drawn from academia, government, and industry.