FASEB SRC: Matricellular Proteins: Fundamental Concepts and New Directions

基质细胞蛋白 (MP) 是细胞外基质的关键组成蛋白，是细胞内不可或缺的组成部分。 调节细胞生理学。通过与细胞受体、生长因子和其他 ECM 成分结合 该蛋白质功能组调节发育和生长、再生、病理、癌症和 老化。 MPs 在许多组织中广泛表达，并在多种组织中具有公认的作用 疾病/病理状况，包括关节炎、骨质疏松症、肌腱病、II 型糖尿病、心血管疾病 疾病、视网膜变性、癌症和转移。我们正在为第七届三年一度的 FASEB SRC 寻求支持 基质细胞蛋白会议，题为“基质细胞蛋白：基本概念和新方向”。 这次会议将于 2022 年夏季举行，其重点是汇集不同的群体 已成立的和新的调查员。我们的目标是重新发现蛋白质被视为蛋白质的意义。 基质细胞蛋白，并为定义该领域的未来铺平道路。虽然有一组蛋白质 被认为是典型的基质细胞蛋白，许多新的分泌蛋白和多功能蛋白可以 也被认为是MP。在基质细胞概念的框架中考虑这些新蛋白质可以帮助 新的研究人员来推进他们的研究。全体会议将拉开会议序幕，其中包括 主讲人。本次会议将介绍细胞粘附、生长因子结合、粘附去除的概念 粘附和基质-基质相互作用——定义基质细胞蛋白质的规范函数。超过 接下来的四天，每天两次会议，每天都将集中于扩展这些概念之一。 上午的会议将重点讨论上述概念，下午的会议将重点讨论 蛋白质家族的具体介绍。周三将有第二位主旨演讲者。虽然大部分被邀请的 发言人和所有会议主席均已收到邀请并已承诺，我们已在 大多数会议都是为了邀请“崭露头角”的科学家——实习生和早期研究人员—— 未来 6 个月令人兴奋的新工作。我们将要求提交摘要，并且将提交两份摘要 从每份提交的摘要中选出，在九场会议中的六场进行演示，然后将有两场 海报会议。其他职业发展活动将包括指导/受训者机会、职业发展 开发研讨会和 MP 特定问答会议。 组织者一直并将继续高度重视营造包容性的环境。两者都 新到现场的调查员和国会议员社区的长期成员将出席会议并 来自学术界、政府和工业界的积极参与本次会议。

Matricellular proteins (MPs) are key component proteins of the extracellular matrix that are integral to modulating cell physiology. Through binding to cellular receptors, growth factors, and other ECM components this functional group of proteins regulates development and growth, regeneration, pathology, cancer, and aging. MPs are broadly expressed in many tissues, and have recognized roles in a variety of disease/pathological conditions, including, arthritis, osteoporosis, tendinopathy, type II diabetes, cardiovascular disease, retinal degeneration, cancer and metasis. We are seeking support for the 7th triennial FASEB SRC matricellular protein conference, titled “Matricelluar Proteins: Fundamental Concepts and New Directions”. The focus of this meeting which will be held in the summer of 2022 is to bring together a diverse group of established and new investigators. Our goal is to rediscover what it means for a protein to be considered a matricellular protein, and to lay a path to define the future of the field. While there are a set of proteins that are considered prototypical matricellular proteins, many new proteins that are secreted and multifunctional can also be considered MP. Considering these new proteins in the framework of the matricellular concept can help new investigators to advance their research. A plenary session will kick-off the meeting and will include a keynote speaker. This session will introduce the concepts of cell adhesion, growth factor binding, adhesion-de- adheision, and matrix-matrix interactions – canonical functions that define matricellular proteins. Over the subsequent four days, two sessions per day, each day will be focused on expanding one of these concepts. Morning sessions will focus on the aforementioned concepts, and the afternoon sessions will be focused on protein family specific presentations. Wednesday will include a 2nd keynote speaker. While most of the invited speakers and all of the session chairs have been invited and committed, we have left open speaker slots in most sessions in order to invite ‘up and coming’ scientists – trainee and early-stage investigators – with exciting new work over the next 6 months. We will request abstract submissions and two abstracts will be selected from each submitted abstract for presentation in six of the nine sessions and then there will be two poster sessions. Additional career development activities will include mentorship/mentee opportunities, career development workshops, and MP specific question/answer sessions. The organizers have been and will continue to be highly focused on fostering an inclusive environment. Both new investigators to the field and long-standing members of the MP community will attend the meeting and actively participate in this meeting, and be drawn from academia, government, and industry.