Admin Core

行政核心将由麦基博士领导，行政办公室将位于 波士顿大学阿尔茨海默病中心（BUADC）和波士顿大学医学院CTE中心 药拟议活动的领导、行政管理和协调工作将以 基于之前2个协调UO 1的经验和成功（McKee，PI，Dams-O 'Connor，PI）。这 U 54应用程序包括3个集成良好的项目，3个核心，并利用BUSM和 ISMMS。每个项目和核心都是对其他项目和核心的补充， 共同关注该计划的主要目标：全面表征神经病理学 TBI和RHI后神经变性的底物，以描述神经病理学之间的关联 负担和生前临床症状，以阐明关键个体（性别，年龄， 损伤程度、损伤时间、基因型、心血管健康和认知储备）和损伤特征 （严重程度，频率），以描述神经病理学负荷和临床症状之间的关联， 确定8个参与脑库中TBI相关帕金森综合征、痴呆和CTE的患病率。这 U 54将开发最大的脑供体队列，在整个研究中具有良好的RHI和TBI病史。 严重度谱和收集的组织将通过UNITE（VA-BU-CLF）进行广泛共享 脑库和国立卫生研究院生物库。U 54还将开发一个病理切片数字图书馆， 将由FITBIR托管和共享。行政核心将提供全面领导和组织 确保定期、协调的科学互动、协调的数据采集以及协调的临床和 跨研究中心的神经病理学评估。行政核心还将管理所有通信， 报告、争端解决、资源使用和达到里程碑。为了实现这些目标， 将组建以下组成部分：科学咨询委员会（SAB），由5名主要成员组成 神经病学、神经病理学、TBI、RHI、AD、ADRD和CTE的独立科学专家; 委员会（EC），该提案的中央决策和政策制定小组; 工作组（SWG）通过分享科学成果确保科学进步和生产力 和讨论;出版物委员会;组织要求监督委员会和财政管理 以马克思管理核心将确保每个项目和核心的所有U 54里程碑和指标 得到满足。鉴于PI、项目和核心领导人之间建立了良好的、富有成效的工作关系 和调查人员在BUSM和ISMSS和他们的成功证明记录，我们有信心， 行政核心可以有效地支持3个相互联系的核心和项目，以充分实现拟议的 U 54的目标和里程碑。

The Administrative Core will be directed by Dr. McKee and the Administrative offices will be located at the Boston University Alzheimer's Disease Center (BUADC) and CTE Center at Boston University School of Medicine. The leadership, administrative management and coordination of the proposed activities will be based on the prior experience and success of 2 previous harmonized UO1s (McKee, PI, Dams-O'Connor, PI). This U54 application includes 3 well-integrated projects, 3 cores and utilizes 8 brain banks across BUSM and ISMMS. Each project and core complements the others so that a synergistic relationship is achieved with a common focus on the major goals of the program: to comprehensively characterize the neuropathological substrate of neurodegeneration after TBI and RHI, to describe the associations between neuropathological burden and ante mortem clinical symptoms, to elucidate the contribution of key individual (gender, age at time of injury, time since injury, genotype, cardiovascular health and cognitive reserve) and injury characteristics (severity, frequency) to describe associations between neuropathological burden and clinical symptoms and to determine the prevalence of TBI-related parkinsonism, dementia and CTE in 8 participating brain banks. This U54 will develop the largest brain donor cohort with well-characterized histories of RHI and TBI across the severity spectrum and the tissue collected will be used for broad sharing through the UNITE (VA-BU-CLF) brain bank and the NIH biobank at ISMMS. The U54 will also develop a digital library of pathology slides that will be hosted and shared by FITBIR. The administrative core will provide overall leadership and organization to ensure regular, coordinated scientific interaction, harmonized data acquisition, and harmonized clinical and neuropathological assessment across sites. The administrative core will also manage all communication, reporting, dispute resolution, use of resources and meeting milestones. To accomplish these goals, the following components will be assembled: a Scientific Advisory Board (SAB) consisting of 5 leading independent scientific experts in neurology, neuropathology, TBI, RHI, AD, ADRD, and CTE; an Executive Committee (EC), the central decision-making and policy development group for the proposal; a Scientific Working Group (SWG) to ensure scientific advancement and productivity through sharing of scientific results and discussion; a Publications Committee; a Tissue Request Oversight committee and a Fiscal Management Committee. The Administrative Core will ensure that all U54 milestones and metrics for each project and core are met. Given the well-established, productive working relationships between the PI, project and core leaders and investigators at BUSM and ISMSS and their proven track record of success, we are confident that the Administrative Core can effectively support the 3 inter-linking cores and projects to fully achieve the proposed goals and milestones of this U54.