Brain Bank Core

脑库核心

• 批准号: 10021466
• 负责人: Ann C. McKee
• 金额: $ 71.01万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10021466
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid beta-Protein; Amyotrophic Lateral Sclerosis; Autopsy; Axon; Biochemical; Biological Assay; Boston; Brain; Chronic; Clinical; Collaborations; Collection; Communities; Consensus; DNA; Data; Development; Diagnosis; Diagnostic; Digital Libraries; Epitopes; Evaluation; Eye; Family member; Fostering; Framingham Heart Study; Future; Gliosis; Goals; Healthcare Systems; Heterogeneity; Immunohistochemistry; Inflammation; Inflammatory; Infrastructure; Injury; Lesion; Link; Measures; Methods; Myelin; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Nervous System Trauma; Outcome; Participant; Pathologic; Pathology; Post-Traumatic Stress Disorders; Protocols documentation; Qualitative Methods; Recording of previous events; Research; Research Personnel; Resolution; Resources; Slide; Specimen; Spinal Cord; Stains; Syndrome; System; Tissues; Traumatic Brain Injury; Universities; Visualization; Work; cohort; cytokine; data harmonization; digital imaging; head impact; innovation; medical schools; neuroinflammation; neuropathology; novel; symposium; white matter

The overarching goals of the Brain Banking Core (BBC) are to conduct and foster research on RHI and TBI and to determine associations with AD, ADRD, CTE, and other neurodegenerative pathology as well as clinical outcomes. The BBC will include 8 brain bank cohorts, 6 from Boston University School of Medicine (BUSM) and the VA Boston Healthcare System: the BU Alzheimer Disease Center (BUADC), Framingham Heart Study (FHS), VA Post-Traumatic Stress Disorder (PTSD), VA amyotrophic lateral sclerosis (ALS), Chronic Effects of Neurotrauma (CENC) and VA-BU-CLF (UNITE) and 2 from the Icahn School of Medicine at Mount Sinai (ISMMS) to systematically evaluate the precise neuropathology of RHI and TBI-related neurodegeneration. These combined brain banks contain over 2500 cases, and include the largest neuropathologically confirmed autopsy cohort of CTE subjects (n= 361) in the world. In addition, the LETBI, CENC, ALS, and UNITE brain banks hold at least 50 cases of remote, moderately-severe TBI with a chronic cavitary lesion (cTBI). The specific aims of the BBC consist of fundamental Core functions, namely to perform state-of-the-art diagnostic neuropathology, optimally store and distribute CNS tissue and other biospecimens, and provide neuropathological data for Projects 1-3 and to the Federal Interagency Traumatic Brain Injury Research (FITBIR) for the general scientific community. All neuropathological protocols will be aligned with those proposed by the NINDS Neuropathological CTE Consensus Conference for biospecimen collection, blocking, staining and storage, which the PI led and helped establish. In addition, a digital library of the pathology slides will be generated for each participant and made publicly available. Finally, the BBC will work to develop novel methods for the assessment of RHI and cTBI-related injury to include axonal and white matter degeneration, gliosis, and inflammation. The specific aims also build upon the significant innovations of the PI and investigators with regard to RHI, cTBI, and CTE and focus on determining the pathological and clinical associations following brain impacts and injury. To accomplish these aims, the BBC will work in close collaboration with the Administration and Data Cores and Projects 1-3, as well as the associated ISMMS Alzheimer's Disease and Research Center Brain Bank and the BUADC. Overall, the BBC will provide a harmonized neuropathological workup and assessment in order to facilitate the storage and distribution of biospecimens, comprehensive diagnoses, digital library creation, and the development of novel quantitative neuropathological measures in order to best capture the chronic sequalae of RHI and TBI. Specimens and data collected by the BBC will be linked to RHI and TBI history determined in Project 1, harmonized clinical outcomes assessed in Project 2, and additional pathological and inflammatory measures determined in Project 3. The harmonized data will be used extensively across Projects 1-3 and made widely available for outside investigators.

脑银行核心（BBC）的首要目标是进行和促进对RHI和TBI的研究 并确定与AD、ADRD、CTE和其他神经退行性病理学以及临床 结果。BBC将包括8个脑库队列，其中6个来自波士顿大学医学院（BUSM） 和VA波士顿医疗保健系统：BU阿尔茨海默病中心（BUADC）、弗雷明汉心脏 研究（FHS），VA创伤后应激障碍（PTSD），VA肌萎缩侧索硬化症（ALS），慢性 神经创伤（CENC）和VA-BU-CLF（UNITE）的影响和来自伊坎医学院的2 Sinai（ISMMS）系统地评估RHI和TBI相关的精确神经病理学 神经变性这些合并的大脑银行包含超过2500个案例，包括最大的 神经病理学证实的CTE受试者尸检队列（n= 361）。此外，LETBI， CENC、ALS和UNITE脑库至少保存了50例远程、中度TBI伴慢性脑损伤的病例。 空洞性病变（cTBI）。英国广播公司的具体目标包括基本的核心职能，即履行 最先进诊断神经病理学，最佳地存储和分配CNS组织和其他生物样本， 并为项目1-3和联邦跨部门创伤性脑损伤提供神经病理学数据 研究（FITBIR）为一般科学界。所有神经病理学方案将与 由NINDS神经病理学CTE共识会议提出的用于生物样本收集的那些， 封闭，染色和存储，PI领导并帮助建立。此外， 将为每名参与者制作病理切片，并公开提供。最后，英国广播公司将工作 开发评估RHI和cTBI相关损伤的新方法，包括轴突和白色物质 变性、神经胶质增生和炎症。具体目标还建立在PI的重大创新之上 和研究人员关于RHI，cTBI和CTE，并专注于确定病理和临床 大脑撞击和损伤后的相关性。为了实现这些目标，BBC将密切合作， 与管理和数据核心和项目1-3以及相关的ISMMS合作 阿尔茨海默病和研究中心脑银行和BUADC。总的来说，BBC将提供 协调神经病理学检查和评估，以便于储存和分发 生物标本，综合诊断，数字图书馆的创建，以及新的定量 神经病理学测量，以便最好地捕获RHI和TBI的慢性后遗症。标本和 英国广播公司收集的数据将与项目1中确定的RHI和TBI历史相关联， 在项目2中评估结局，并在项目2中确定其他病理和炎症指标 3.协调后的数据将广泛用于项目1-3，并广泛提供给外部 investigators.