Admin Core

行政核心将由麦基博士领导，行政办公室将设在 波士顿大学阿尔茨海默病中心(BUADC)和波士顿大学学院的CTE中心 医学。拟议活动的领导、行政管理和协调将以 关于之前2个协调一致的UO1(McKee，PI，DAMS-O‘Connor，PI)的先前经验和成功。这 U54应用程序包括3个集成良好的项目、3个核心并利用了跨BUSM和 ISMMS。每个项目和核心都是相辅相成的，因此通过一个 共同关注该计划的主要目标：全面描述神经病理 脑外伤后神经退行性变的底物与RHI，以描述神经病理之间的关系 负担和临死前临床症状，以阐明关键个体(性别、年龄)的贡献 受伤、受伤时间、基因、心血管健康和认知储备)和受伤特征 (严重性，频率)来描述神经病理负担与临床症状之间的关系，并 确定8个参与脑库的脑损伤相关帕金森病、痴呆症和CTE的患病率。这 U54将发展最大的脑捐赠者队列，在全国范围内具有良好的RHI和TBI历史 严重程度谱和收集的组织将用于通过联合(VA-BU-CLF)进行广泛共享 ISMMS的脑库和NIH生物库。U54还将开发一个病理切片的数字图书馆， 将由FITBIR托管和共享。行政核心将提供全面领导和组织 确保定期、协调的科学互动、协调的数据获取和协调的临床和 跨部位的神经病理评估。管理核心还将管理所有通信， 报告、争端解决、资源利用和会议里程碑。为了实现这些目标， 将组建以下组成部分：科学咨询委员会(SAB)，由5名领导 神经学、神经病理学、脑损伤、RHI、AD、ADRD和CTE方面的独立科学专家；高管 委员会(EC)，该提案的中央决策和政策制定小组；科学 通过共享科学成果确保科学进步和生产力的工作组 和讨论；出版物委员会；组织要求监督委员会和财务管理 委员会审议阶段。管理核心将确保每个项目和核心的所有U54里程碑和指标 都相遇了。由于PI、项目和核心领导之间建立了良好、富有成效的工作关系 和BUSM和ISMS的调查人员以及他们被证明的成功记录，我们相信 行政核心可以有效地支持3个相互关联的核心和项目，以充分实现拟议的 本次U54的目标和里程碑。

The Administrative Core will be directed by Dr. McKee and the Administrative offices will be located at the Boston University Alzheimer's Disease Center (BUADC) and CTE Center at Boston University School of Medicine. The leadership, administrative management and coordination of the proposed activities will be based on the prior experience and success of 2 previous harmonized UO1s (McKee, PI, Dams-O'Connor, PI). This U54 application includes 3 well-integrated projects, 3 cores and utilizes 8 brain banks across BUSM and ISMMS. Each project and core complements the others so that a synergistic relationship is achieved with a common focus on the major goals of the program: to comprehensively characterize the neuropathological substrate of neurodegeneration after TBI and RHI, to describe the associations between neuropathological burden and ante mortem clinical symptoms, to elucidate the contribution of key individual (gender, age at time of injury, time since injury, genotype, cardiovascular health and cognitive reserve) and injury characteristics (severity, frequency) to describe associations between neuropathological burden and clinical symptoms and to determine the prevalence of TBI-related parkinsonism, dementia and CTE in 8 participating brain banks. This U54 will develop the largest brain donor cohort with well-characterized histories of RHI and TBI across the severity spectrum and the tissue collected will be used for broad sharing through the UNITE (VA-BU-CLF) brain bank and the NIH biobank at ISMMS. The U54 will also develop a digital library of pathology slides that will be hosted and shared by FITBIR. The administrative core will provide overall leadership and organization to ensure regular, coordinated scientific interaction, harmonized data acquisition, and harmonized clinical and neuropathological assessment across sites. The administrative core will also manage all communication, reporting, dispute resolution, use of resources and meeting milestones. To accomplish these goals, the following components will be assembled: a Scientific Advisory Board (SAB) consisting of 5 leading independent scientific experts in neurology, neuropathology, TBI, RHI, AD, ADRD, and CTE; an Executive Committee (EC), the central decision-making and policy development group for the proposal; a Scientific Working Group (SWG) to ensure scientific advancement and productivity through sharing of scientific results and discussion; a Publications Committee; a Tissue Request Oversight committee and a Fiscal Management Committee. The Administrative Core will ensure that all U54 milestones and metrics for each project and core are met. Given the well-established, productive working relationships between the PI, project and core leaders and investigators at BUSM and ISMSS and their proven track record of success, we are confident that the Administrative Core can effectively support the 3 inter-linking cores and projects to fully achieve the proposed goals and milestones of this U54.