FOX CORE Phase II Research Core #1 Synthesis

项目摘要 综合与发现核心 第二阶段COBRE将继续其使命，集中不同的科学家团队发现新的 探测生物目标功能的分子。在第一阶段，我们的COBRE开发了一种仪器， 核心，独特的特拉华州，使分子发现，纯化和分析。的增长 我们的中心和通过我们的核心设施提供的服务的广度促使我们重新组织这一 第二阶段的两个核心设施：合成和发现（SD）核心设施和 分析化学核心设施。拟议的合成和发现（SD）核心设施包括 用于小分子合成、高通量催化剂发现、计算 和显微镜功能，将继续被整个IDEA网络的研究人员广泛使用， 超越。在第二阶段，我们将扩大设施的范围，为非专科医生提供化学服务 在生物医学研究领域中。该设施将使生物学家、生物化学家、工程师和其他 获得定制的分子合成，他们不能轻易地自己制造它们。SD核心的目标 设施将包括（1）为设施制定行政框架和征聘工作人员 提供核心服务，以及（2）建立定制合成实验室（CSL）， 一系列合成服务，包括小分子合成、纯化、化学分析开发和 高通量反应开发和平行合成。

Project Summary Synthesis and Discovery Core This Phase II COBRE will continue on its mission to focus a diverse team of scientists on the discovery of new molecules that probe the function of biological targets. During Phase I, our COBRE developed an instrumentation core, unique to the state of Delaware, that enabled molecular discovery, purification and analysis. The growth of our center and the breadth of services offered through our core facilities have prompted us to reorganize this instrumentation into two core facilities for Phase II: the Synthesis and Discovery (SD) Core Facility and the Analytical Chemistry Core Facility. The proposed Synthesis and Discovery (SD) Core Facility consists of instrumentation and infrastructure for small molecule synthesis, high throughput catalyst discovery, computation and microscopy capabilities that will continue to be broadly used by researchers across the IDeA network and beyond. During Phase II, we will expand the scope of the facility to provide chemistry services to non-specialists across the biomedical research spectrum. The facility will enable biologists, biochemists, engineers, and others access to custom synthesis of molecules they cannot easily make them themselves. The goals of the SD Core Facility will include (1) the development of an administrative framework for the facility and the recruitment of staff to provide core services, and (2) establishment of a Custom Synthesis Laboratory (CSL) that will provide a broad array of synthetic services including small molecule synthesis, purification, chemical assay development and high throughput reaction development and parallel synthesis.