FOX CORE Phase II Research Core #1 Synthesis

项目摘要 合成与发现核心 这个第二阶段的科布雷将继续其使命，将一个不同的科学家团队集中在发现新的 探测生物靶标功能的分子。在第一阶段，我们的科布雷开发了一种仪器 特拉华州独有的核心，使分子发现、纯化和分析成为可能。的增长 我们的中心和通过我们的核心设施提供的广泛服务促使我们对此进行重组 第二阶段的两个核心设施：综合和发现(SD)核心设施和 分析化学核心设施。拟议的综合和发现(SD)核心设施包括 用于小分子合成、高通量催化剂发现、计算的仪器和基础设施 和显微镜功能，将继续被整个IDEA网络和 更远一点。在第二阶段，我们将扩大该设施的范围，为非专业人员提供化学服务 在生物医学研究领域。该设施将使生物学家、生物化学家、工程师和其他人 获得定制合成分子的途径他们不能轻易地自己制造。SD核心的目标 该设施将包括：(1)为该设施制定行政框架和招聘工作人员 提供核心服务，以及(2)建立定制合成实验室(CSL)，将提供广泛的 一系列的合成服务，包括小分子合成、纯化、化学分析开发和 高通量反应开发和并行合成。

Project Summary Synthesis and Discovery Core This Phase II COBRE will continue on its mission to focus a diverse team of scientists on the discovery of new molecules that probe the function of biological targets. During Phase I, our COBRE developed an instrumentation core, unique to the state of Delaware, that enabled molecular discovery, purification and analysis. The growth of our center and the breadth of services offered through our core facilities have prompted us to reorganize this instrumentation into two core facilities for Phase II: the Synthesis and Discovery (SD) Core Facility and the Analytical Chemistry Core Facility. The proposed Synthesis and Discovery (SD) Core Facility consists of instrumentation and infrastructure for small molecule synthesis, high throughput catalyst discovery, computation and microscopy capabilities that will continue to be broadly used by researchers across the IDeA network and beyond. During Phase II, we will expand the scope of the facility to provide chemistry services to non-specialists across the biomedical research spectrum. The facility will enable biologists, biochemists, engineers, and others access to custom synthesis of molecules they cannot easily make them themselves. The goals of the SD Core Facility will include (1) the development of an administrative framework for the facility and the recruitment of staff to provide core services, and (2) establishment of a Custom Synthesis Laboratory (CSL) that will provide a broad array of synthetic services including small molecule synthesis, purification, chemical assay development and high throughput reaction development and parallel synthesis.