Quantitative Sciences Core

项目摘要--量化科学核心 量化科学(QS)核心通过将早期阶段和 拥有深思熟虑设计实验所需的分析专业知识的老牌艾滋病毒/艾滋病调查人员， 使用严格的统计方法进行研究，并在适当的情况下使用最先进的统计方法， 生物信息学，或用来分析复杂数据集的计算生物学方法。前身为 生物统计和计算核心，新名称反映了为 下一个供资周期，现在包括生物统计学、计算生物学、基因组学和微生物 生物信息学和人口健康分析。质量体系核心有四个具体目标：1)提供咨询， 分析和资助支持服务；2)以量化方法提供教育和指导；3)发展 艾滋病毒/艾滋病研究的创新方法；4)促进内部、CFAR内部、CFAR之间和外部 合作。QS核心的首要任务是提供有用的统计和分析资源和服务 CFAR社区。为了实现这一目标，QS核心将继续提供临时咨询和步行- 在临床上，对手稿进行统计分析，并合作准备拨款提案。在……里面 特别是，核心确保早期调查人员得到充分的指导、培训和分析 支持。在这个资助周期中，我们将为所有CFAR飞行员获奖者提供免费的数据分析支持， 这将直接有助于它们的成功结果。通过来自公爵的附属量化核心 癌症研究所、全球健康研究所、临床和翻译科学研究所和儿童 健康和发展倡议，CFAR调查人员现在将有机会在更广泛的领域获得专业知识 一系列量化领域，包括药物基因组学和电子健康记录。QS核心将 通过年度数据分析研讨会和协作项目提供教育和指导 生物统计学研究生与CFAR研究人员配对。此外，QS Core将提供 艾滋病毒/艾滋病研究的定量方法综合研究教育方案，包括 暑期实习以及数据科学、统计学和复杂分析分析方面的研讨会。这个 QS Core通过以下方式寻求创新：(1)开发新的培训和教育机会，如无预约诊所 和各种讲习班；以及(2)与CFAR核心和/或合作制定方法 调查人员要改进数据来源和统计的严谨性。最后，QS核心广泛合作 与Duke CFAR中的其他核心和科学工作组(SWGs)合作；有多个联合项目 临床、发展和免疫学中心，以及北卡罗来纳大学 教堂山CFAR生物统计学核心，与南卡罗来纳大学的艾滋病毒/艾滋病研究人员 没有州内的CFAR。

PROJECT SUMMARY – Quantitative Sciences Core The Quantitative Sciences (QS) Core enhances HIV/AIDS research at Duke by linking early stage and established HIV/AIDs investigators with the analytic expertise needed to thoughtfully design experiments, conduct research using statistically rigorous approaches, and where appropriate, use state-of-the-art statistical, bioinformatics, or computational biology methods to dissect complex data sets. Formerly known as the Biostatistics and Computational Core, the new name reflects the expanded range of services proposed for the next funding cycle, now encompassing biostatistics, computational biology, genomics and microbial bioinformatics, and population health analysis. The QS Core has four Specific Aims: 1) Provide consultation, analysis, and grant support services; 2) Provide education and mentoring in quantitative methods; 3) Develop innovative methods in HIV/AIDS research; and 4) Foster internal, intra-CFAR, inter-CFAR, and external collaborations. The QS Core's top priority is to provide useful statistical and analytical resources and services to the CFAR community. To accomplish this, the QS Core will continue to offer ad hoc consultations and walk- in clinics, conduct statistical analyses for manuscripts, and collaborate in the preparation of grant proposals. In particular, the Core ensures that early stage investigators receive adequate mentoring, training, and analytic support. In this funding cycle, we will provide free data analysis support for all CFAR Pilot Grant awardees, which will contribute directly to their successful outcomes. Through affiliated quantitative cores from the Duke Cancer Institute, Global Health Research Institute, Clinical and Translational Sciences Institute, and Child Health and Development Initiative, CFAR investigators will now have access to expertise in a much wider range of quantitative fields, including Pharmacogenomics and Electronic Health Records. The QS Core will provide education and mentoring through annual workshops in data analysis, and collaborative projects that pair biostatistics graduate students with CFAR investigators. Additionally, the QS Core will offer a comprehensive research education program in quantitative methods for HIV/AIDS research that includes summer internships as well as workshops in data science, statistics, and the analysis of complex assays. The QS Core seeks innovation by (1) developing new training and education opportunities, such as walk-in clinics and a variety of workshops; and (2) methods development in collaboration with CFAR Cores and/or investigators to improve data provenance and statistical rigor. Lastly, the QS Core collaborates extensively with other Cores and Scientific Working Groups (SWGs) in the Duke CFAR; there are multiple joint projects with the Clinical, Development, and Immunology Cores, as well as with the University of North Carolina at Chapel Hill CFAR Biostatistics Core, and with HIV/AIDS researchers at the University of South Carolina who do not have an in-state CFAR.