Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome

癌症免疫学和微生物组交叉点的生物信息学培训计划

• 批准号: 10457252
• 负责人: Cliburn C Chan
• 金额: $ 27.97万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10457252
• 关键词: Address; Area; Bioinformatics; Biological Assay; Biology; Cancer Biology; Communities; Complex; Coupled; Data; Data Set; Discipline; Disease remission; Education; Educational Materials; Educational process of instructing; Elements; Ensure; Faculty; Future; High-Throughput Nucleotide Sequencing; Immune system; Immunology; Immunophenotyping; Immunotherapy; Institution; Interdisciplinary Study; Knowledge; Learning; Malignant Neoplasms; Methodology; Methods; Microbiology; Modernization; Mus; Outcome; Participant; Patients; Postdoctoral Fellow; Process; Productivity; Reproducibility; Research; Research Personnel; Scientist; Series; Statistical Methods; Structure; Students; T-cell receptor repertoire; Technology; Time; Training; Training Programs; Work; anticancer research; bioinformatics pipeline; cancer education; cancer genomics; cancer immunotherapy; cancer therapy; complex data; design; experience; experimental study; graduate student; high throughput analysis; human data; improved; interest; learning materials; learning outcome; microbial community; microbiome; microbiome analysis; microbiome sequencing; online resource; research study; response; satisfaction; single-cell RNA sequencing; skills; statistics; technological innovation; tool; tumor; tumor immunology

PROJECT SUMMARY/ABSTRACT Modern cancer immunology research studies the complex interactions among the tumor, host immune system and microbiome, and depends on an array of technologies that were unimaginable a decade ago. To design, execute, and interpret experiments using these technologies, it is not sufficient for cancer researchers to understand the biology of cancer; they must also understand the assay technology and the analysis methods used to interpret the resulting data. The complexity presents a challenging task and a huge unmet need in the education of cancer researchers, as what needs to be learned cuts across multiple disciplines: cancer biology, immunology, microbiology, statistics and bioinformatics. To address this pressing knowledge gap for cancer researchers, we propose a modular series of annual two-week summer courses that spans and integrates the analysis of microbiome, immunology and cancer high-throughput data. These courses will include coverage of the biology, assays, online resources, bioinformatics pipelines and statistical methods needed to rigorously analyze and correctly interpret the results. Comprehensive educational material with integrated data sets from the course will be made publicly available as scientific notebooks to cancer researchers everywhere.

项目摘要/摘要 现代肿瘤免疫学研究肿瘤与宿主免疫系统之间复杂的相互作用 和微生物组，并依赖于一系列十年前无法想象的技术。去设计， 使用这些技术执行和解释实验，癌症研究人员不足以 了解癌症的生物学;他们还必须了解检测技术和分析方法 用于解释结果数据。这种复杂性提出了一项具有挑战性的任务和一个巨大的未满足的需求， 癌症研究人员的教育，因为需要学习的东西跨越多个学科：癌症生物学， 免疫学、微生物学、统计学和生物信息学。为了解决这一紧迫的癌症知识缺口， 研究人员，我们提出了一个模块化的系列每年两周的夏季课程，跨越和整合， 微生物组、免疫学和癌症高通量数据分析。这些课程将包括 生物学，分析，在线资源，生物信息学管道和统计方法需要严格 分析并正确解释结果。综合教育材料，包含来自 该课程将作为科学笔记本向世界各地的癌症研究人员公开提供。