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Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome

癌症免疫学和微生物组交叉点的生物信息学培训计划

基本信息

批准号：
10171567
负责人：
Cliburn C Chan
金额：
$ 31.31万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10171567
关键词：
Address Area Bioinformatics Biological Assay Biology Cancer Biology Communities Complex Coupled Data Data Set Discipline Disease remission Education Educational Materials Educational process of instructing Elements Ensure Faculty Future High-Throughput Nucleotide Sequencing Immune system Immunology Immunophenotyping Immunotherapy Institution Interdisciplinary Study Knowledge Learning Malignant Neoplasms Methodology Methods Microbiology Modernization Mus Outcome Participant Patients Postdoctoral Fellow Process Productivity Reproducibility Research Research Personnel Scientist Series Statistical Methods Structure Students T-cell receptor repertoire Technology Time Training Training Programs Work anticancer research bioinformatics pipeline cancer education cancer genomics cancer immunotherapy cancer therapy complex data design experience experimental study graduate student high throughput analysis human data improved interest learning materials learning outcome microbial community microbiome microbiome analysis microbiome sequencing online resource research study response satisfaction single-cell RNA sequencing skills statistics technological innovation tool tumor tumor immunology

项目摘要

PROJECT SUMMARY/ABSTRACT Modern cancer immunology research studies the complex interactions among the tumor, host immune system and microbiome, and depends on an array of technologies that were unimaginable a decade ago. To design, execute, and interpret experiments using these technologies, it is not sufficient for cancer researchers to understand the biology of cancer; they must also understand the assay technology and the analysis methods used to interpret the resulting data. The complexity presents a challenging task and a huge unmet need in the education of cancer researchers, as what needs to be learned cuts across multiple disciplines: cancer biology, immunology, microbiology, statistics and bioinformatics. To address this pressing knowledge gap for cancer researchers, we propose a modular series of annual two-week summer courses that spans and integrates the analysis of microbiome, immunology and cancer high-throughput data. These courses will include coverage of the biology, assays, online resources, bioinformatics pipelines and statistical methods needed to rigorously analyze and correctly interpret the results. Comprehensive educational material with integrated data sets from the course will be made publicly available as scientific notebooks to cancer researchers everywhere.

项目总结/文摘