Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome

项目概要/摘要 现代癌症免疫学研究研究肿瘤、宿主免疫系统之间复杂的相互作用 和微生物组，并且依赖于一系列十年前难以想象的技术。去设计， 使用这些技术执行和解释实验，癌症研究人员还不足以 了解癌症的生物学；他们还必须了解测定技术和分析方法 用于解释结果数据。这种复杂性提出了一项具有挑战性的任务和巨大的未满足的需求 癌症研究人员的教育，因为需要学习的内容涉及多个学科：癌症生物学， 免疫学、微生物学、统计学和生物信息学。解决这一紧迫的癌症知识差距 研究人员，我们提出了一系列模块化的年度为期两周的夏季课程，涵盖并整合了 微生物组、免疫学和癌症高通量数据分析。这些课程将包括 严格要求所需的生物学、分析、在线资源、生物信息学管道和统计方法 分析并正确解释结果。综合教育材料，包含来自以下机构的集成数据集： 该课程将作为科学笔记本向世界各地的癌症研究人员公开。

PROJECT SUMMARY/ABSTRACT Modern cancer immunology research studies the complex interactions among the tumor, host immune system and microbiome, and depends on an array of technologies that were unimaginable a decade ago. To design, execute, and interpret experiments using these technologies, it is not sufficient for cancer researchers to understand the biology of cancer; they must also understand the assay technology and the analysis methods used to interpret the resulting data. The complexity presents a challenging task and a huge unmet need in the education of cancer researchers, as what needs to be learned cuts across multiple disciplines: cancer biology, immunology, microbiology, statistics and bioinformatics. To address this pressing knowledge gap for cancer researchers, we propose a modular series of annual two-week summer courses that spans and integrates the analysis of microbiome, immunology and cancer high-throughput data. These courses will include coverage of the biology, assays, online resources, bioinformatics pipelines and statistical methods needed to rigorously analyze and correctly interpret the results. Comprehensive educational material with integrated data sets from the course will be made publicly available as scientific notebooks to cancer researchers everywhere.