Resource and Service Section

资源与服务科

• 批准号: 10469585
• 负责人: Cathleen M Lutz
• 金额: $ 14.36万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10469585
• 关键词: Archives; Awareness; Behavioral; Bioinformatics; Biological Markers; CRISPR/Cas technology; Client; Clinical Trials; Communities; Complement; Development; Disease; Disease model; Duchenne muscular dystrophy; Environment; Faculty; Fee-for-Service Plans; Feedback; Fees; Funding; Gene Expression; Generations; Goals; Hand; Histology; Hospitals; Individual; Infrastructure; Knockout Mice; Laboratory mice; Link; Liquid substance; Maintenance; Marketing; Microscopy; Mission; Modeling; Mus; Mutant Strains Mice; Patients; Pharmacology; Phenotype; Physiology; Preclinical Testing; Process; Production; Program Development; Rare Diseases; Reagent; Recording of previous events; Reporting; Research; Research Personnel; Resource Development; Resources; Sales; Service delivery model; Services; Spinal Muscular Atrophy; Structure; Technology; The Jackson Laboratory; Therapeutic; United States National Institutes of Health; Work; base; cost; data access; experience; genome editing; improved; mouse model; operation; outreach; precision genetics; preservation; programs; public repository; quality assurance; repository; service programs; somatic cell gene editing; tool; treatment center; user-friendly; web site

PROJECT SUMMARY RESOURCE AND SERVICE CORE The overall goal of the Resource & Service Core is to publicize the mice and services developed through the JCPG to the broader scientific community. To accomplish this goal, the Core will work closely with the Bioinformatics Core in the development of the JCPG website and portal to allow public access to resources and tools. The distribution of mice will leverage the existing mouse production infrastructure at The Jackson Laboratory (JAX) as well as the existing NIH-funded Mutant Mouse Resource and Research Center (MMRRC) for a seamless transition of models from the core to the community. The Core will add new services and refine existing service to ultimately develop into a fee for service program that operates in professional service environment, with customer quotes, project execution, deliverables, finalized reports and feedback. JAX has an almost 90-year history of developing, archiving, and distributing laboratory mice, and their derivative resources and information, to the scientific community. The JCPG will complement and expand resource stewardship at JAX by leveraging the deep expertise of JAX researchers and services. JAX is seeing a predictable demand for model generation services as a result of CRISPR/Cas9 genome editing technologies and the reduction in costs for patient sequencing. This, in turn, has increased the demand for phenotyping and ancillary services, such as histology, gene expression, microscopy, etc. that can be tailored for each disease model. Another growing demand that the JCPG will help to satisfy is the need for pharmacology and efficacy-based preclinical testing in mice. Operation of the JCPG Resource and Service Core will serve to: 1) Provide new mouse models to the scientific community, following well-established processes for, rigor, quality assurance and customer service. Mice generated by the Disease Modeling Unit (DMU) will pass seamlessly through our customer service and production infrastructure to the JAX-MMRRC repository for maintenance, distribution and preservation. Each step of the process will be facilitated by tools and processes developed by the Bioinformatics section of the JCPG. 2) Refine existing and consider new key JAX services with input from our clients and make them available to the biomedical community on a fee-based mechanism with a focus on maximizing awareness and external availability using existing JAX outreach and marketing infrastructure and efforts. 3) Develop an integrated management and operational structure that weaves together core services and delivers them as efficiently as possible. Successful implementation of the Resource/Services core depends on our experienced management team to integrate individual service cores into a seamless program.

项目摘要资源和服务核心 资源与服务核心的总体目标是宣传通过 JCPG向更广泛的科学界宣传。为了实现这一目标，核心将与 开发联合专家小组网站和门户网站的生物信息学核心，使公众能够获取资源 和工具。MICE的分发将利用杰克逊博物馆现有的MICE生产基础设施 实验室(JAX)以及现有的NIH资助的突变小鼠资源和研究中心(MMRRC) 以实现模型从核心到社区的无缝过渡。核心将增加新的服务并改进 现有服务最终发展为以专业服务方式运营的收费服务计划 环境，包括客户报价、项目执行、交付成果、最终报告和反馈。 JAX在开发、归档和分发实验室小鼠方面已经有近90年的历史，他们的 向科学界提供衍生资源和信息。中英联合联络小组将补充和扩大 通过利用JAX研究人员和服务的深厚专业知识，实现JAX的资源管理。 由于CRISPR/Cas9基因组，JAX看到了对模型生成服务的可预测需求 编辑技术和患者测序成本的降低。这反过来又增加了需求。 用于表型鉴定和辅助服务，如组织学、基因表达、显微镜等，可以 为每种疾病模型量身定做。中英联合联络小组将帮助满足的另一个日益增长的需求是 小鼠的药理学和基于疗效的临床前试验。 JCPG资源和服务核心的运行将服务于：1)为科学研究提供新的鼠标模型 社区，遵循严格、质量保证和客户服务的成熟流程。老鼠 由疾病建模单元(DMU)生成的数据将通过我们的客户服务和 将生产基础设施转移到JAX-MMRRC存储库进行维护、分发和保存。每个人 这一过程的步骤将通过由生物信息学部分开发的工具和过程来促进 JCPG。2)根据我们客户的意见，改进现有的关键JAX服务并考虑新的关键JAX服务 以收费机制向生物医学界提供，重点是最大限度地提高认识和 利用现有的日本宇宙航空研究开发机构的外联和营销基础设施和努力向外部提供。3)开发一个 集成管理和运营结构，将核心服务编织在一起，并以 尽可能高效地工作。资源/服务核心的成功实施取决于我们的经验 管理团队将各个服务核心整合到一个无缝计划中。