Preclinical/Co-Clinical Section

项目摘要临床前/联合临床核心 杰克逊实验室(JAX)和杰克逊精密遗传学实验室中心(JCPG)占据了 在全球生物医学研究界独一无二的利基市场。虽然我们看不到病人，但很多人 这些人受益于我们对JAX病毒数以千计的不同小鼠品系的管理 可用于人类疾病研究。这不仅仅是我们的老鼠；我们的教职员工研究人员， 遗传学和哺乳动物生物学方面的专业知识，直接与医院、医疗机构的研究人员合作 中心和世界各地的一系列其他面向临床的合作伙伴。因此，中日联合联络小组将利用一个“枢纽”运作。 JCPG形成了哺乳动物疾病模型的一部分，该模型集成了各种 与各种合作伙伴建立一系列协作的“辐条”，共同制作PRECIST 临床前疾病模型。JCPG的临床前/联合临床核心将与专家临床、患者、 研究和行业合作伙伴，促进现有和提名的最佳创作和应用 项目。与JCPG协调核心、临床前/联合临床核心和指导 委员会将应用一系列基准标准来努力实现翻译成 临床实践。最终，我们将通过提供更高级的服务费用来进一步扩大我们的影响 扩大社区获取JAX资源的途径。以达到中日联合联络小组目前的目标并加以完善 并扩展其未来的业务，临床前/联合临床核心将：1)征集、评估和确定新的 临床前/联合临床项目申请，并向指导委员会提出建议，供#年通过 日中关系。2)通过类似生产的管道推出新型号，包括表征和药品 测试，以便它们可以更切实地为未来的临床应用提供信息。3)继续发展壮大 现有的JAX基础设施可促进临床数据和样本的访问，支持 鼠标信息和患者数据。

PROJECT SUMMARY PRECLINICAL/CO-CLINICAL CORE The Jackson Laboratory (JAX) and The Jackson Laboratory Center for Precision Genetics (JCPG) occupy a unique niche within the global biomedical research community. Although we do not see patients, many of these individuals have benefited from our stewardship of the thousands of different mouse strains that JAX provides for use in human disease research. And it is not just our mice; our faculty researchers, with deep expertise in genetics and mammalian biology, collaborate directly with investigators at hospitals, medical centers and an array of other clinically oriented partners worldwide. Thus, the JCPG will operate using a “hub and spokes” concept where the JCPG forms part of a mammalian disease model “hub” that integrates a variety of JAX resources to establish an array of collaborative “spokes” with a variety of partners to co-produce precise preclinical disease models. The Preclinical/Co-clinical core of the JCPG will work with expert clinical, patient, research and industry collaborators to facilitate optimal creation and application of existing and nominated projects. Together with the JCPG Coordination Core, the Preclinical/Co-clinical Core and the Steering Committee will apply a series of benchmark standards to work toward the eventual goal of translation into clinical practice. Ultimately, we will further extend our impact by providing a more advanced Fee for Service approach to broaden community access to JAX resources. To meet current goals of the JCPG and to refine and expand its future operation, the Preclinical/Co-clinical Core will: 1) Solicit, evaluate and prioritize new preclinical/co-clinical project requests and provide recommendations to the Steering Committee for adoption by the JCPG. 2) Advance new models through the production-like pipelines, with characterization and drug testing so they can more tangibly inform future clinical applications. 3) Continue to develop and expand existing JAX infrastructure to facilitate access to clinical data and samples, supporting data exchange between mouse information and patient data.