Preclinical/Co-Clinical Section

临床前/协同临床核心项目总结 杰克逊实验室（JAX）和杰克逊实验室精密遗传学中心（JCPG）占据了 在全球生物医学研究界的独特利基。虽然我们没有看到病人，但许多 这些人受益于我们对数千种不同小鼠品系的管理， 用于人类疾病研究。不仅仅是我们的老鼠，我们的研究人员， 遗传学和哺乳动物生物学方面的专业知识，直接与医院，医疗机构的研究人员合作， 中心和一系列其他面向临床的全球合作伙伴。因此，JCPG将使用一个“枢纽”来运作 JCPG是哺乳动物疾病模型“枢纽”的一部分， 利用JAX资源与各种合作伙伴建立一系列协作“辐条”， 临床前疾病模型。JCPG的临床前/协同临床核心将与临床专家、患者、 研究和工业合作者，以促进现有和提名的最佳创造和应用 项目与JCPG协调核心、临床前/协同临床核心和指导 委员会将采用一系列基准标准，努力实现翻译成 临床实践最终，我们将通过提供更先进的服务费来进一步扩大我们的影响力 这是一种扩大社区对JAX资源访问的方法。为了实现JCPG的当前目标， 并扩大其未来的运作，临床前/协同临床核心将：1）征求，评估和优先考虑新的 临床前/协同临床项目申请，并向指导委员会提供建议，供以下机构采用： JCPG。2)通过类似生产的管道推进新模型，并进行表征和药物 测试，以便他们可以更切实地为未来的临床应用提供信息。3)继续发展和扩大 现有的JAX基础设施，以促进对临床数据和样本的访问，支持 鼠标信息和患者数据。

PROJECT SUMMARY PRECLINICAL/CO-CLINICAL CORE The Jackson Laboratory (JAX) and The Jackson Laboratory Center for Precision Genetics (JCPG) occupy a unique niche within the global biomedical research community. Although we do not see patients, many of these individuals have benefited from our stewardship of the thousands of different mouse strains that JAX provides for use in human disease research. And it is not just our mice; our faculty researchers, with deep expertise in genetics and mammalian biology, collaborate directly with investigators at hospitals, medical centers and an array of other clinically oriented partners worldwide. Thus, the JCPG will operate using a “hub and spokes” concept where the JCPG forms part of a mammalian disease model “hub” that integrates a variety of JAX resources to establish an array of collaborative “spokes” with a variety of partners to co-produce precise preclinical disease models. The Preclinical/Co-clinical core of the JCPG will work with expert clinical, patient, research and industry collaborators to facilitate optimal creation and application of existing and nominated projects. Together with the JCPG Coordination Core, the Preclinical/Co-clinical Core and the Steering Committee will apply a series of benchmark standards to work toward the eventual goal of translation into clinical practice. Ultimately, we will further extend our impact by providing a more advanced Fee for Service approach to broaden community access to JAX resources. To meet current goals of the JCPG and to refine and expand its future operation, the Preclinical/Co-clinical Core will: 1) Solicit, evaluate and prioritize new preclinical/co-clinical project requests and provide recommendations to the Steering Committee for adoption by the JCPG. 2) Advance new models through the production-like pipelines, with characterization and drug testing so they can more tangibly inform future clinical applications. 3) Continue to develop and expand existing JAX infrastructure to facilitate access to clinical data and samples, supporting data exchange between mouse information and patient data.