Special Mouse Strains Resource

摘要 了解遗传多样性对人类疾病的影响是该专业的核心。 小鼠品系资源（SMSR）赠款。最近的研究结果表明，SARS-CoV-2变异令人担忧 （VOCs）可以感染普通实验室小鼠，这既创造了机会，也引起了关注。的 令人担忧的是，SARS-CoV-2已成为一种人畜共患病的病原体，将影响使用小鼠进行的研究。 关于这些挥发性有机化合物将如何影响实验室小鼠，无论是小鼠对小鼠， 传播是可能的，或者如何调查动物园的感染。我们必须了解 感染过程、发病机理和传播性，包括通过种质， 可以制定策略来保护依赖于使用小鼠的研究。数据 通过本提案产生的信息将填补这些知识空白， 制定预防或管理疫情的政策和做法，保护研究 利用小岛屿发展中国家的资源和基础设施 奇怪的是，VOC在近交系小鼠中的感染也提供了机会。差动 本提案中概述的VOCs近交系感染将增加我们对 宿主遗传学的感染，提供了一个巨大的机会，以改善我们的整体战略， 设计和使用SARS-CoV-2小鼠模型，以实现最终的测试目标 干预和治疗。

Abstract Understanding the effects of genetic diversity on human disease is the nexus of the Specialty Mouse Strains Resource (SMSR) grants. Recent findings that SARS-CoV-2 variants of concern (VOCs) can infect common laboratory mice creates both and opportunity and a concern. The concern is that SARS-CoV-2 has become a zoonotic agent that will impact research using mice. Little is known about how these VOCs will affect laboratory mice, whether mouse-to-mouse transmission is possible, or how to survey vivaria for infection. It is critical that we understand the course of infection, pathogenesis, and transmissibility including through germplasm so that strategies can be developed to protect research that depends on the use of mice. The data generated through this proposal will address these gaps in knowledge and will be of value to those developing policies and practices to prevent or manage outbreaks, protecting the research resources and infrastructure utilizing mice Paradoxically, the infection of VOCs in inbred mice also presents an opportunity. The differential infection among inbred strains for VOCs outlined in this proposal will increase our knowledge of host genetics of infection, providing a tremendous opportunity to improve our overall strategies in the design and use of mouse models for SARS-CoV-2, towards the ultimate goal of testing interventions and therapeutics.