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Special Mouse Strains Resource

特殊小鼠品系资源

基本信息

批准号：
10400461
负责人：
Cathleen M Lutz
金额：
$ 46.72万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10400461
关键词：
2019-nCoV ACE2 Address Affect Animal Model Animals Autoimmune Biomedical Research Body Weight COVID-19 Communities Complex DNA sequencing Data Disease Outbreaks Drug or chemical Tissue Distribution Embryo Transfer Exposure to Feces Fertilization in Vitro Gap Junctions Genetic Genetic Variation Genetic study Genome Goals Grant Health Histologic Horizontal Disease Transmission Human Human Genetics Inbred Mouse Inbred Strain Inbreeding Infection Intervention K-18 conjugate Kidney Kinetics Knowledge Laboratory mice Lead Leadership Liver Lung Modeling Monitor Mouse Strains Mus Mutation Pathogenesis Phenotype Policies Population Predisposition Reporting Reproducibility Research Research Infrastructure Resources Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 B.1.351 SARS-CoV-2 variant Sampling Sentinel Sexual Reproduction Source South African Spleen Standardization Surveys System Technology Testing The Jackson Laboratory Therapeutic Tissues Transgenic Animals Variant Viral Viral Load result Virus Zoonoses cohort design genetic variant human disease improved infection management insight interest male medical specialties mouse model prevent reproductive organ respiratory response sperm cell transmission process variants of concern viral genomics

项目摘要

Abstract Understanding the effects of genetic diversity on human disease is the nexus of the Specialty Mouse Strains Resource (SMSR) grants. Recent findings that SARS-CoV-2 variants of concern (VOCs) can infect common laboratory mice creates both and opportunity and a concern. The concern is that SARS-CoV-2 has become a zoonotic agent that will impact research using mice. Little is known about how these VOCs will affect laboratory mice, whether mouse-to-mouse transmission is possible, or how to survey vivaria for infection. It is critical that we understand the course of infection, pathogenesis, and transmissibility including through germplasm so that strategies can be developed to protect research that depends on the use of mice. The data generated through this proposal will address these gaps in knowledge and will be of value to those developing policies and practices to prevent or manage outbreaks, protecting the research resources and infrastructure utilizing mice Paradoxically, the infection of VOCs in inbred mice also presents an opportunity. The differential infection among inbred strains for VOCs outlined in this proposal will increase our knowledge of host genetics of infection, providing a tremendous opportunity to improve our overall strategies in the design and use of mouse models for SARS-CoV-2, towards the ultimate goal of testing interventions and therapeutics.

摘要了解遗传多样性对人类疾病的影响是该专业的纽带小鼠品系资源(SMSR)资助。最近的研究发现，SARS-CoV-2变种令人担忧挥发性有机化合物(VOCs)可以感染普通实验室小鼠，既创造了机会，又令人担忧。这个令人担忧的是，SARS-CoV-2已经成为一种人畜共患病病毒，将影响使用小鼠进行的研究。关于这些VOCs将如何影响实验室小鼠，无论是老鼠对老鼠，我们知之甚少。传播是可能的，或者如何调查感染。重要的是我们要了解感染过程、发病机制和传播性，包括通过种质可以制定策略来保护依赖于老鼠使用的研究。数据通过该计划产生的数据将解决这些知识差距，并将对那些制定政策和做法以预防或管理疫情，保护研究利用MICE的资源和基础设施矛盾的是，近交系小鼠中VOCs的感染也提供了一个机会。差异化在这项提案中概述的VOCs近交系菌株之间的感染将增加我们对感染的宿主遗传学，提供了一个巨大的机会来改进我们在 SARS-CoV-2小鼠模型的设计和使用，朝着最终测试目标迈进干预和治疗。